A swelling on the fore head- the tip of the iceberg

An epidermoid cyst is a benign cyst usually found on the skin, developing out of ectodermal tissue. These are relatively uncommon benign cysts or tumors to arise over the surface of the brain. They are mostly intra dural and few percentages are located in the diploic space. We are reporting a case of 51 years old lady presenting with a swelling over forehead which was diagnosed to be an intradiploic epidermoid cyst of the frontal bone with an intracranial extension which is an unusual presentation causing clinical dilemma. Radiological findings led to a correct diagnosis and with complete removal patient is doing well

Investigating The Prevalence and Management of Pain and Discomfort Associated with Prosthodontic Appliances

Background: This study investigates the prevalence and management of pain and discomfort associated with prosthodontic appliances, including dentures, crowns, bridges, and dental implants, among a diverse sample of 500 participants. Methods: A cross-sectional observational study was conducted, collecting data on demographic characteristics, prevalence, and severity of pain and discomfort, and management strategies. Statistical analysis, including chi-square tests and logistic regression, was used to explore associations. Results: Dentures had the highest prevalence of pain and discomfort (45%), followed by crowns (30%), bridges (22%), and dental implants (18%). Mean severity scores were highest for dental implants (4.5), followed by dentures (5.2), bridges (4.1), and crowns (3.8). Demographics, including age, gender, education level, and socioeconomic status, influenced these experiences. Conclusion: The study highlights the need for individualized care and patient education, especially for procedures associated with higher discomfort levels. It underscores the importance of considering patient expectations and tailoring treatment recommendations. Further research should explore factors contributing to pain and discomfort and the effectiveness of management strategies

Establishing inoculum threshold levels for Bean common mosaic virus strain blackeye cowpea mosaic infection in cowpea seed

Bean common mosaic virus strain blackeye cowpea mosaic (BCMV-BlCM) is an important seed-borne virus infecting cowpea and is transmitted both by seeds and aphids. Infected cowpea seeds can act as primary source of inoculum for disease epidemics. Four field experiments were conducted during 2003 - 2006 to assess the role of different amounts of seed-borne inoculum in the dissemination of BCMVBlCM virus in cowpea under field conditions. The identity of BCMV-BlCM was confirmed by ELISA and IC-RT-PCR. Plants infected at an early growth stage appeared to serve as the primary source for subsequent virus spread by aphids. The mean disease incidence during four field experiments reached88-93% in plots sown with 10% infected seed. The disease incidence in plots sown with 5% infected seed recorded 46-63% while for plants raised from 3 and 2% BCMV-BlCM seed infection, disease incidence reached 32-49% and 17-23%, respectively. Mean yield losses in terms of seed yield per plant from four field experiments were 74 and 54% for initial seed infection of 10 and 5%, respectively. Seed infection of 2% BCMV-BlCM incidence resulted in an average of 24% mean seed yield loss/plant-1. The infection appeared to decrease the seed yield in terms of number and size. The BCMV incidence in harvested seed ranged from 0.3 - 19% for the different levels of initial seed infection. The field experiments demonstrated that sowing > 1% BCMV-BlCM infected seed can lead to significant losses in grain yield, while the spread of BCMV-BlCM infection resulting from sowing 1% infected seed did not significantly decrease seed yield. The role of establishing damage or inoculum thresholds from BCMVBlCM seed-borne infections is discussed in the present study.Keywords: Cowpea, potyvirus, seed-borne virus, thresholds, yield los

Hemophagocytic lymphohistiocytosis secondary to infections:a tertiary care experience

Background: Hemophagocytic lymphohistiocytosis is an uncommon complication of various conditions. It is characterized by immune dysregulation and massive cytokine release causing multiorgan dysfunction. It is classified as primary and secondary to various etiologies like infections, malignancies and autoimmune disease. As it has high mortality, clinician awareness is important for early diagnosis and improved outcome. Aim of the study was to study the etiologies, clinical manifestations, complications and laboratory features in patients diagnosed with infection associated hemophagocytic syndrome (IAHS).Methods: We have done retrospective analysis of all cases diagnosed to have Infection Associated Hemophagocytic Syndrome (IAHS) between March 2012 to November 2015 in a 1000 bedded tertiary care hospital in south India.Results: Total five cases detected. Most of the cases are related to tropical infections (80%). All of them presented with fever, cytopenias and organomegaly. Ferritin and Triglycerides were elevated in all patients. Bone marrow hemophagocytosis was observed in 80% of cases. Diagnostic protocol of HLH 2004 was followed. Only 20% survival observed.Conclusions: IAHS is a rare fulminant complication associated with diagnostic and therapeutic challenges because of overlapping clinical features with sepsis. Increased physician awareness, early diagnosis and therapeutic interventions may improve survival

Biochemical characterization of Fusarium oxysporum f. sp. cubense isolates from India

The Fusarium wilt caused by Fusarium oxyspoum f. sp. cubense (Foc) is a major biotic constraint for banana production. The characteristics of F. oxyspoum f. sp. cubense isolates were investigated using electrophoretic studies of isozyme and whole-cell protein. The morphological characteristics of the isolates were very similar to each other. All the Foc isolates were pathogenic to banana cultivar 'Nanjangud Rasabale' but they did not induce any disease symptoms on cultivar 'Cavendish'. F. oxyspoum (Isolate 6) did not induce wilt symptoms on either 'Nanjangud' or 'Cavendish' cultivar. Isozyme banding patterns showed 46 scoreable markers and cluster analysis with UPGMA using genetic distance showed that the isolates belonged to three main groups. Group 1 contained isolates 1, 2, 4, 5, 7 and isolate 3 and 6 were placed in group 2 and 3. Results indicated that the estimated intra-specific variation may be more pronounced with isozyme analysis than with protein markers. The level of isozyme variability detected within F. oxysporum f.sp. cubense suggested that it is reliable, efficient and effective in determining genetic relationships among Foc isolates

Clinical profile of sickle cell syndromes: experience at a tertiary care centre in South India

Background: Sickle cell syndromes are commonly encountered inherited haematological disorders regarding which sparse published data are available from Telangana State. Methods: Prospective study of 55 patients diagnosed to have sickle cell syndromes at our tertiary care teaching hospital in Hyderbad, Telangana State, South India. Results: Their mean age was 19.9 (range 3-48) years; there were 35 males. Consanguinity was noted in 31%. History of cholecystectomy was evident in 5 cases. Blood transfusions were received in the past in 52% of cases. Symptoms at presentation were jaundice (85%), pain (80%), fatiguability (60%), pallor (30%), dyspnoea (29%), lump abdomen (7%) and leg ulcer (3%). Acute chest syndrome was seen in 10.9% cases. Physical examination revealed pallor (90%), icterus (80%) hepatomegaly (49%) and splenomegaly (41%). Mean haemoglobin at presentation was 8.3 g/dL. Sickle cells were seen in peripheral smear in 51%. Sickling test was positive in all after induction. Characterization of haemoglobin by high performance liquid chromatography revealed homozygous sicke cell anaemia was evident in 22/ 43 (51.2%), sickle thalassemia in 16/43 (37.2 %) and sickle cell trait in 5/43 (11.6 %). Conclusions: Sickle cell disease should be considered in the differential diagnosis while evaluating patients presenting with anaemia and skeletal pains. Prompt recognition and management improves survival and eventual prognosis in these patients

Analytical expressions for inductances of 3D air core inductors for integrated power supply

This work presents analytical expressions for the DC inductance of 3D air core inductors with circular cross section pillars (CCSP) and rectangular cross section pillars (RCSP). We consider the following four types of inductor structures: (1) a toroid with CCSP; (2) a toroid with RCSP; (3) a solenoid with RCSP; and (4) a solenoid with CCSP. For each type, a unique analytical model is developed for obtaining DC inductance. High frequency (1-100 MHz) effects on inductance are also discussed. The inductance values predicted by the proposed analytical models of the first three types of inductor structures are in an acceptable agreement with numerical Finite Element Analysis (FEA) solutions, where the maximum difference is 7.3%. Also, our analytical model for the fourth type inductor reduces the error, when correlated with FEA inductance value, up to 6× compared to previously published models. A comparison of results using proposed analytical expressions with published measured values as well as our measurement data demonstrates error ranging from 0.5 to 16.2%, while conventional formulae show errors of up to 143%. The results of the proposed models could serve as a good initial estimate for power supply on chip (PwrSoC) and power supply in package (PSiP) applications

Inter-cluster reactivity of Metallo-aromatic and anti-aromatic Compounds and Their Applications in Molecular Electronics: A Theoretical Investigation

Local reactivity descriptors such as the condensed local softness and Fukui function have been employed to investigate the inter-cluster reactivity of the metallo-aromatic (Al4Li- and Al4Na-) and anti-aromatic (Al4Li4 and Al4Na4) compounds. We use the concept of group softness and group Fukui function to study the strength of the nucleophilicity of the Al4 unit in these compounds. Our analysis shows that the trend of nucleophilicity of the Al4 unit in the above clusters is as follows; Al4Li- > Al4Na- > Al4Li4 > Al4Na 4 For the first time we have used the reactivity descriptors to show that these clusters can act as electron donating systems and thus can be used as a molecular cathode.Comment: 23 pages, 1 figure and 1 table of conten

Molecular diversity of seed-borne Fusarium species associated with maize in India

A total of 106 maize seed samples were collected from different agro-climatic regions ofIndia. Sixty-two Fusarium isolates were recovered, 90% of which were identified as Fusarium verticillioidesbased on morphological and molecular characters. Use of the tef-1alpha gene corrected/refinedthe morphological species identifications of 11 isolates, and confirmed those of the remaining isolates. Genetic diversityamong the Fusarium isolates involved multilocus fingerprinting profiles by Inter Simple Sequence Repeats (ISSR) UPGMAand tef-1 alpha gene phenetic analyses; for which, we observed no significant differences among the isolates based ongeographic origin or fumonisin production; most of the subdivision related to species. Genotyping was performed on theF. verticillioides isolates, using 12 primer sets from the fumonisin pathway, to elucidate the molecular basis of fumonisinproduction or non-production. One fumonisin-negative isolate, UOMMF-16, was unable to amplify nine of the 12 fumonisincluster genes tested. We also used the CD-ELISA method to confirm fumonisin production for our 62 Fusariumisolates. Only 15 isolates were found to be fumonisin-negative. Interestingly, genotypic characterization revealed six isolateswith various gene deletion patterns that also tested positive for the production of fumonisins via CD-ELISA. Ourfindings confirm the importance of molecular studies for species delimitation, and for observing genetic and phenotypicdiversity, among the Fusaria.</p