The role of opinions of consumers of educational services about the training of future doctors in the practical training in the Ural State Medical University

the results of students’ opinions and potential employers about practical training in the USMUПредставлены результаты исследования мнения студентов и потенциальных работодателей о производственной практике в УГМ

Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study

To analyze the patterns of human beta-defensin-1, 2, 4 (hBDs) expression in human lung tumors. Materials and Methods: Tissue samples of surgically resected human lung tumors (squamous cell carcinoma (SCC), n = 10; adenocarcinoma (AC), n = 10) paired with conditionally normal tissue samples were analized for expression of hBD-1, 2, 4 mRNA by semiquantitive RT-PCR. Results: In a number of studied lung cancer tissue samples, overexpression of defensin mRNA was registered: hBD-1 mRNA (50% of SCC and 60% AC), hBD-2 mRNA (60% of SCC and 50% of AC) or hBD-4 (40% of SCC and 20% AC). No correlation was detected between the levels of hBD-1, hBD-2 and hBD-4 mRNA and histological type, differentiation grade of the tumor, and the stage of the disease, as well as the content of hBD-2 peptide in blood serum of lung cancer patients. Conclusion: Human beta-defensins-1 and -2 are often up-regulated in human lung tumors.Цель: проанализировать особенности экспрессии мРНК бета-дефенсинов-1, 2, 4 (hBDs) в ткани опухоли легкого человека. Материалы и методы: с помощью метода полуколичественного RT-PCR-анализа изучали уровень экспрессии мРНК hBD-1, 2, 4 в образцах ткани хирургически удаленных опухолей легкого человека (плоскоклеточный рак — ПКР, n = 10; аденокарцинома — AК, n = 10) по сравнению с образцами условно-нормальной ткани легкого тех же пациентов. Результаты: в ряде исследованных образцов опухолей легкого выявлена повышенная экспрессия мРНК hBD-1 (50% ПКР и 60% AК), hBD-2 (60% ПКР и 50% АК) или hBD-4 (40% ПКР и 20% AК). Зависимости между уровнем экспрессии бета-дефенсинов и гистологическим типом опухоли, стадией заболевания и содержанием пептида hBD-2 в сыворотке крови больных не установлено. Выводы: в ткани опухоли легкого человека часто активирована экспрессия hBD-1 и hBD-2

Formation of students of the medical-preventive faculty of readiness to implementation of labor functions of the doctor-therapeutic at the production practice

Представлены мнения студентов о практике в Уральском государственном медицинском университетеThe results of students’ opinions about practical training in the Ural state medical universit

FORMATION OF PROFESSIONAL SKILLS AND WORK EXPERIENCE OF STUDENTS ENOROLLED IN THE PROGRAMME «GENERAL MEDICINE» AND «PEDIATRICS” DURING THE INTERNSHIP THROUGH THE COLLABORATION WITH THE EMPLOYERS

В статье рассмотрены вопросы подготовки обучающихся медицинского профиля на производственной практикеThe article deals with the training of medical students during the internshi

Synthesis of acyclic nucleoside analogues by one-step Vorbrüggen glyco-sylation of 1,2,4-triazolo[1,5-a]pyrimidine-7-ones

New analogues of acyclovir have been prepared by reacting 1,2,4 -triazolo[1,5-a]pyrimidin-7-ones 1а-i and (2-acetoxyethoxy)methyl acetate 2 in the presence of trimethylsilyl trifluoromethanesulfonate as a catalyst. The interaction between the compounds 1а-е and 2 has led to a mixture of N3 and N4 isomers. In contrast, the reaction of compounds 1g-i and 2 proceeded selectively to form N3 isomers. In the case of compounds 1a-c the predominant product is the one with the acyclic moiety in azine ring (N4 isomer). Interaction between 1d-f and 2 has led to mixtures comprising mainly N3 isomer. It has been found that the ratio of glycosylation products 1 and 2 are thermodynamically controlled. The structure of the obtained compounds has been proved by 1Н, 13С, two-dimensional 1Н-13С NMR spectroscopy and X-ray analysis

Monitoring of views of leaders of students' practical training аs an element of quality control of the educational process

The quality control of the educational process should be implemented at all stages of the educational program. During practical training a student is situated in the workplace when his teacher working in the health system evaluates the student's professional readiness. The results of such monitoring should be interpreted with the tools of quality management, the ause-and-effect relations for the development of corrective measures should be exploredКонтроль качества образовательного процесса необходимо осуществлять на всех этапах реализации образовательной программы. На производственной практике обучающийся находится на рабочем месте, где оценку его профессиональной готовности к работе дает руководитель, работающий в системе здравоохранения. Результаты таких ониторингов необходимо интерпретировать при помощи инструментов менеджмента качества, исследовать причинно-следственные связи для выработки результативных корректирующих мероприяти

Non-natural nucleosides based on 1,2,4-triazolo[5,1-c][1,2,4]triazin-4(6H)- ones

Two regioselective methods for the synthesis of nucleosides in the series of 3-phenyl- and 3- ethoxycarbonyl-1,2,4-triazolo[5,1-c][1,2,4]triazin-4-ones were developed. The first route involves a Vorbrüggen glycosylation reaction. The second one is based on condensation of 1,2,4- triazolo[5,1-c][1,2, 4]triazin-4-one sodium salts with protected 1-bromo-sugar derivatives

Quasi-stationary States of Dust Flows Under Poynting-Robertson Drag: New Analytical and Numerical Solutions

The effect of solar or stellar radiation on dust particles' trajectories (the Poynting-Robertson drag) has been studied by a number of authors and applied to interplanetary dust dynamics in numerical computations. Meanwhile some important features of dust flows can be studied analytically by implementing our novel hydrodynamical approach to use the continuity equation written in the particle's orbital elements as coordinates (Gor'kavyi, Ozernoy, & Mather 1997). By employing this approach and integrating the continuity equation, we are able to find two integrals of motion when the Poynting-Robertson drag dominates the dissipative forces in the dust flow. These integrals of motion enable us to explore basic characteristics of dust flows from any sources in the Solar system (such as asteroids, comets, Kuiper belt, etc.) or in another planetary system. In particular, we have reproduced the classical solution $n(r)\propto r^{-1}$ that approximately represents the overall distribution of dust in the Solar system. We have also investigated various factors that could be responsible for the deviations of the power law index in $n(r)\propto r^{\delta}$ from $\delta=-1$, including the influences of the orbital characteristics of dust sources, the evaporation of dust particles, as well as mixtures of dust particles of both asteroidal and cometary origin. We have calculated the masses and number densities of asteroidal and cometary components of the zodiacal cloud at different distances from the Sun.Comment: Accepted for publication in ApJ, v. 488, Oct. 10, 1997; 22 pages, Latex, 12 Postscript figure

Spin-spin coupling constants 13C-15N and 1H-15N in the investigation of azido-tetrazole tautomerism in a series of 2-azidopyrimidines

A new method was developed for the investigation of an azido-tetrazole equilibrium based on using a complex analysis of 13C-15N and 1H-15N spin-spin coupling constants. The use of this approach became possible due to the selective inclusion of 15N isotopes into the structures of 2-azidopyrimidines and their cyclic analogs tetrazolo[1,5-a]pyrimidines. © 2013 Springer Science+Business Media New York