Surface Rupture of the November 2002 M7.9 Denali Fault Earthquake, Alaska, and Comparison to Other Strike-Slip Ruptures

On November 3, 2002, a moment-magnitude (Mw) 7.9 earthquake produced 340 km of surface rupture on the Denali fault and two related faults in central Alaska. The rupture, which proceeded from west to east, began with a 40-km-long break on a previously unknown thrust fault. Estimates of surface slip on this thrust were 3-6 m. Next came the principal surface break, along 220 km of the Denali fault. There, right-lateral offset averaged almost 5 m and increased eastward to a maximum of nearly 9 m. Finally, slip turned southeastward onto the Totschunda fault, where dextral offsets up to 3 m continued for another 70 km. This three-part rupture ranks among the longest documented strike-slip events of the past two centuries. The surface-slip distribution supports and clarifies models of seismological and geodetic data that indicated initial thrusting followed by rightlateral strike slip, with the largest moment release near the east end of the Denali fault. The Denali fault ruptured beneath the Trans-Alaska oil pipeline. The pipeline withstood almost 6 m of lateral offset, because engineers designed it to survive such offsets based on pre-construction geological studies. The Denali fault earthquake was typical of large-magnitude earthquakes on major intracontinental strike-slip faults, in the length of the rupture, the multiple fault strands that ruptured, and the variable slip along strike

Surface Rupture and Slip Distribution of the Denali and Totschunda Faults

The 3 November 2002 Denali fault, Alaska, earthquake resulted in 341 km of surface rupture on the Susitna Glacier, Denali, and Totschunda faults. The rupture proceeded from west to east and began with a 48-km-long break on the previously unknown Susitna Glacier thrust fault. Slip on this thrust averaged about 4 m (Crone et al., 2004). Next came the principal surface break, along 226 km of the Denali fault, with average right-lateral offsets of 4.5–5.1 m and a maximum offset of 8.8 m near its eastern end. The Denali fault trace is commonly left stepping and north side up. About 99 km of the fault ruptured through glacier ice, where the trace orientation was commonly influenced by local ice fabric. Finally, slip transferred southeastward onto the Totschunda fault and continued for another 66 km where dextral offsets average 1.6–1.8 m. The transition from the Denali fault to the Totschunda fault occurs over a complex 25-km-long transfer zone of right-slip and normal fault traces. Three methods of calculating average surface slip all yield a moment magnitude of Mw 7.8, in very good agreement with the seismologically determined magnitude of M 7.9. A comparison of strong-motion inversions for moment release with our slip distribution shows they have a similar pattern. The locations of the two largest pulses of moment release correlate with the locations of increasing steps in the average values of observed slip. This suggests that slipdistribution data can be used to infer moment release along other active fault traces.PublishedS23–S52reserve

Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma

Primary effusion lymphoma (PEL) is an AIDS-defining cancer. It is associated with Kaposi sarcoma-associated herpesvirus. To date, no sequencing studies have been conducted for this cancer. We used X chromosome-targeted next-generation sequencing to identify 33 genes with coding region mutations in 100% of cases, including in interleukin 1 receptor-associated kinase 1 (IRAK1). IRAK1 kinase modulates toll-like receptor signaling-mediated immune signaling. It binds to MyD88 adapter protein, which is mutated in a subset of diffuse large B-cell lymphomas. IRAK1, however, had not been linked to cancer. This IRAK1 mutant is constitutively active and essential for PEL survival. This highlights the importance of innate immunity signaling as drivers for cancer, particularly those caused by viruses. It also suggests IRAK1 kinase may be a potential target for therapy

Argumentation in school science : Breaking the tradition of authoritative exposition through a pedagogy that promotes discussion and reasoning

The value of argumentation in science education has become internationally recognised and has been the subject of many research studies in recent years. Successful introduction of argumentation activities in learning contexts involves extending teaching goals beyond the understanding of facts and concepts, to include an emphasis on cognitive and metacognitive processes, epistemic criteria and reasoning. The authors focus on the difficulties inherent in shifting a tradition of teaching from one dominated by authoritative exposition to one that is more dialogic, involving small-group discussion based on tasks that stimulate argumentation. The paper builds on previous research on enhancing the quality of argument in school science, to focus on how argumentation activities have been designed, with appropriate strategies, resources and modelling, for pedagogical purposes. The paper analyses design frameworks, their contexts and lesson plans, to evaluate their potential for enhancing reasoning through foregrounding the processes of argumentation. Examples of classroom dialogue where teachers adopt the frameworks/plans are analysed to show how argumentation processes are scaffolded. The analysis shows that several layers of interpretation are needed and these layers need to be aligned for successful implementation. The analysis serves to highlight the potential and limitations of the design frameworks

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive and fast assay to quantify in vitro DUB enzyme activity using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Unlike other current assays, this method uses unmodified substrates, such as diubiquitin topoisomers. By analyzing 42 human DUBs against all diubiquitin topoisomers we provide an extensive characterization of DUB activity and specificity. Our results confirm the high specificity of many members of the OTU and JAMM DUB families and highlight that all USPs tested display low linkage selectivity. We also demonstrate that this assay can be deployed to assess the potency and specificity of DUB inhibitors by profiling 11 compounds against a panel of 32 DUBs

KIMA: Noise: A visual sound installation on urban noise

KIMA: Noise is a participatory art piece inviting audiences to explore impact of urban noises interactively. Using specific urban sound sources, the audience experiences noise as spatial soundscapes, responding to it, physically engaging and interacting with it. KIMA: Noise creates awareness for the phenomenon of noise pollution. The paper looks at preeminent research in the field, and draws conclusions of how sound affects us as individuals. The art project KIMA: Noise is introduced technically and conceptually

Garlic Accelerates Red Blood Cell Turnover and Splenic Erythropoietic Gene Expression in Mice: Evidence for Erythropoietin-Independent Erythropoiesis

Garlic (Allium sativum) has been valued in many cultures both for its health effects and as a culinary flavor enhancer. Garlic's chemical complexity is widely thought to be the source of its many health benefits, which include, but are not limited to, anti-platelet, procirculatory, anti-inflammatory, anti-apoptotic, neuro-protective, and anti-cancer effects. While a growing body of scientific evidence strongly upholds the herb's broad and potent capacity to influence health, the common mechanisms underlying these diverse effects remain disjointed and relatively poorly understood. We adopted a phenotype-driven approach to investigate the effects of garlic in a mouse model. We examined RBC indices and morphologies, spleen histochemistry, RBC half-lives and gene expression profiles, followed up by qPCR and immunoblot validation. The RBCs of garlic-fed mice register shorter half-lives than the control. But they have normal blood chemistry and RBC indices. Their spleens manifest increased heme oxygenase 1, higher levels of iron and bilirubin, and presumably higher CO, a pleiotropic gasotransmitter. Heat shock genes and those critical for erythropoiesis are elevated in spleens but not in bone marrow. The garlic-fed mice have lower plasma erythropoietin than the controls, however. Chronic exposure to CO of mice on garlic-free diet was sufficient to cause increased RBC indices but again with a lower plasma erythropoietin level than air-treated controls. Furthermore, dietary garlic supplementation and CO treatment showed additive effects on reducing plasma erythropoietin levels in mice. Thus, garlic consumption not only causes increased energy demand from the faster RBC turnover but also increases the production of CO, which in turn stimulates splenic erythropoiesis by an erythropoietin-independent mechanism, thus completing the sequence of feedback regulation for RBC metabolism. Being a pleiotropic gasotransmitter, CO may be a second messenger for garlic's other physiological effects

Linking soil microbial community structure to potential carbon mineralization: A continental scale assessment of reduced tillage

Potential carbon mineralization (Cmin) is a commonly used indicator of soil health, with greater Cmin values interpreted as healthier soil. While Cmin values are typically greater in agricultural soils managed with minimal physical disturbance, the mechanisms driving the increases remain poorly understood. This study assessed bacterial and archaeal community structure and potential microbial drivers of Cmin in soils maintained under various degrees of physical disturbance. Potential carbon mineralization, 16S rRNA sequences, and soil characterization data were collected as part of the North American Project to Evaluate Soil Health Measurements (NAPESHM). Results showed that type of cropping system, intensity of physical disturbance, and soil pH influenced microbial sensitivity to physical disturbance. Furthermore, 28% of amplicon sequence variants (ASVs), which were important in modeling Cmin, were enriched under soils managed with minimal physical disturbance. Sequences identified as enriched under minimal disturbance and important for modeling Cmin, were linked to organisms which could produce extracellular polymeric substances and contained metabolic strategies suited for tolerating environmental stressors. Understanding how physical disturbance shapes microbial communities across climates and inherent soil properties and drives changes in Cmin provides the context necessary to evaluate management impacts on standardized measures of soil microbial activity

Leisure Behavior Pattern Stability During the Transition from Adolescence to Young Adulthood

Leisure is an important context in which human development occurs. Changes in leisure behavior patterns may indicate changing developmental needs or reflect contextual changes that impact leisure behavior. The transition from adolescence to young adulthood provides an excellent opportunity for the study of the stability of leisure behavior as individuals' contexts are changed with the adoption of adult roles and the potential for disruption of leisure patterns exists. Previous studies investigating leisure and the transition from adolescence to young adulthood have tended to be cross-sectional and focus on specific leisure behaviors rather than identifying patterns of leisure behavior. The present study involved a longitudinal investigation of leisure behavior patterns over a three-year period during the transition from adolescence to young adulthood, and determined the nature of leisure pattern stability and instability during this period. In general, leisure pattern stability was the most common pathway into young adulthood. The patterns of leisure behavior and the nature of the changes that occurred with the transition from adolescence to young adulthood differed to some degree for males and females, although similarities in patterns and transitions were also found.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45285/1/10964_2004_Article_411255.pd