Parametrization of Born-Infeld Type Phantom Dark Energy Model

Applying the parametrization of dark energy density, we can construct directly independent-model potentials. In Born-Infeld type phantom dark energy model, we consider four special parametrization equation of state parameter. The evolutive behavior of dark energy density with respect to red-shift $z$, potentials with respect to $\phi$ and $z$ are shown mathematically. Moreover, we investigate the effect of parameter $\eta$ upon the evolution of the constructed potential with respect to $z$. These results show that the evolutive behavior of constructed Born-Infeld type dark energy model is quite different from those of the other models.Comment: 5 pages, 4 figures, Accepted for publication in Astrophysics & Space Scienc

OmOm Diagnostic for Dilaton Dark Energy

$Om$ diagnostic can differentiate between different models of dark energy without the accurate current value of matter density. We apply this geometric diagnostic to dilaton dark energy(DDE) model and differentiate DDE model from LCDM. We also investigate the influence of coupled parameter $\alpha$ on the evolutive behavior of $Om$ with respect to redshift $z$. According to the numerical result of $Om$, we get the current value of equation of state $\omega_{\sigma0}$=-0.952 which fits the WMAP5+BAO+SN very well.Comment: 6 pages and 6 figures

Born-Infeld Type Phantom Model in the ω−ω′\omega-\omega' Plane

In this paper, we investigate the dynamics of Born-Infeld(B-I) phantom model in the $\omega-\omega'$ plane, which is defined by the equation of state parameter for the dark energy and its derivative with respect to $N$(the logarithm of the scale factor $a$). We find the scalar field equation of motion in $\omega-\omega'$ plane, and show mathematically the property of attractor solutions which correspond to $\omega_\phi\sim-1$, $\Omega_\phi=1$, which avoid the "Big rip" problem and meets the current observations well.Comment: 6 pages, 3 figures, some references adde

Global Conformational Dynamics of a Y-Family DNA Polymerase during Catalysis

High-resolution analysis of protein, and DNA conformational changes during DNA polymerization, established relationships between the enzymatic function and conformational dynamics of individual domains for a DNA polymerase

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will require the translation of proof-of-principle concepts into a scalable, controlled, and regulated cell manufacturing process. We have previously demonstrated that hESC can be directed to differentiate into pancreatic progenitors that mature into functional glucose-responsive, insulin-secreting cells in vivo. In this study we describe hESC expansion and banking methods and a suspension-based differentiation system, which together underpin an integrated scalable manufacturing process for producing pancreatic progenitors. This system has been optimized for the CyT49 cell line. Accordingly, qualified large-scale single-cell master and working cGMP cell banks of CyT49 have been generated to provide a virtually unlimited starting resource for manufacturing. Upon thaw from these banks, we expanded CyT49 for two weeks in an adherent culture format that achieves 50–100 fold expansion per week. Undifferentiated CyT49 were then aggregated into clusters in dynamic rotational suspension culture, followed by differentiation en masse for two weeks with a four-stage protocol. Numerous scaled differentiation runs generated reproducible and defined population compositions highly enriched for pancreatic cell lineages, as shown by examining mRNA expression at each stage of differentiation and flow cytometry of the final population. Islet-like tissue containing glucose-responsive, insulin-secreting cells was generated upon implantation into mice. By four- to five-months post-engraftment, mature neo-pancreatic tissue was sufficient to protect against streptozotocin (STZ)-induced hyperglycemia. In summary, we have developed a tractable manufacturing process for the generation of functional pancreatic progenitors from hESC on a scale amenable to clinical entry

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for genetic changes occurring during culture. Most lines were analyzed at an early and late passage. Single-nucleotide polymorphism (SNP) analysis revealed that they included representatives of most major ethnic groups. Most lines remained karyotypically normal, but there was a progressive tendency to acquire changes on prolonged culture, commonly affecting chromosomes 1, 12, 17 and 20. DNA methylation patterns changed haphazardly with no link to time in culture. Structural variants, determined from the SNP arrays, also appeared sporadically. No common variants related to culture were observed on chromosomes 1, 12 and 17, but a minimal amplicon in chromosome 20q11.21, including three genes expressed in human ES cells, ID1, BCL2L1 and HM13, occurred in >20% of the lines. Of these genes, BCL2L1 is a strong candidate for driving culture adaptation of ES cells

Postgraduate Employment Outcomes of Undergraduate and Graduate Public Health Students:A Scoping Review

ObjectivesA key goal of schools and programs of public health is to prepare graduates for careers in the public health workforce after graduation, but are they achieving this goal? We assessed how the employment outcomes of students earning public health degrees are collected and described in the literature.MethodsUsing the Kirkpatrick model of training evaluation as a framework, we conducted a 6-step scoping review: (1) formulating the research question, (2) identifying relevant studies, (3) selecting studies, (4) charting the data, (5) collating and summarizing the results, and (6) consulting stakeholders. We included articles published from January 1, 1993, through July 4, 2020, that provided data on employment status, employment sector/industry, job function, or salary of public health graduates. We excluded articles that were not written in English and were about dual-degree (ie, doctor of medicine-master of public health) students. We found and reviewed 630 articles.ResultsWe found 33 relevant articles. Most articles focused on a single school and combined multiple graduating classes, focused on subspecializations of public health, or focused on graduates' satisfaction with their curriculum but not employment outcomes. Data were inconsistently categorized, and studies were difficult to compare.ConclusionsResearch on public health graduates' employment outcomes is scarce and does not follow consistent protocols. New standards should be adopted to systematize the collection of data on employment outcomes of public health graduates

Numerical modeling and experimental investigations of thermal performance of reflective insulations

Reflective insulations are being used in attics, flat roof, and wall systems. Numerical modeling and experimental investigations were conducted to assess the thermal performance of assemblies with reflective insulations. In this article, the present model was used to verify the use of the ASTM C-518 test method for measuring the effective thermal resistances (R-values) of sample stacks comprising reflective insulations. Two tests were conducted on sample stacks using heat flow meter apparatus. The sample stack consists of two expanded polystyrene layers and a reflective insulation installed in between. The model predictions agreed with the measured heat fluxes within \ub11%. The article also discusses the combined effect of heat transfer by convection and radiation in the airspace facing the reflective insulation, showing that the derived R-value from the test data resulted in underestimation of the effective R-value of the sample stackPeer reviewed: YesNRC publication: Ye