Examination of silver-graphite lithographically printed resistive strain sensors

This paper reports the design and manufacture of three differing types of resistive strain sensitive structures fabricated using the Conductive Lithographic Film (CLF) printing process. The structures, utilising two inks prepared with silver and graphite particulates as the conductive phase, have been analysed to determine electrical and mechanical properties with respect to strain, temperature and humidity when deposited on four alternative substrate materials (GlossArt, PolyArt, Teslin and Melinex)

Multi-Donor longitudinal antibody repertoire sequencing reveals the existence of public antibody clonotypes in HIV-1 infection

Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an infection-naive state through acute and chronic infection using next-generation sequencing. This analysis revealed the existence of “public” antibody clonotypes that were shared among multiple HIV-infected individuals. The HIV-1 reactivity for representative antibodies from an identified public clonotype shared by three donors was confirmed. Furthermore, a meta-analysis of publicly available antibody repertoire sequencing datasets revealed antibodies with high sequence identity to known HIV-reactive antibodies, even in repertoires that were reported to be HIV naive. The discovery of public antibody clonotypes in HIV-infected individuals represents an avenue of significant potential for better understanding antibody responses to HIV-1 infection, as well as for clonotype-specific vaccine development

Development of fluorescent probes for bioimaging applications

Fluorescent probes, which allow visualization of cations such as Ca2+, Zn2+ etc., small biomolecules such as nitric oxide (NO) or enzyme activities in living cells by means of fluorescence microscopy, have become indispensable tools for clarifying functions in biological systems. This review deals with the general principles for the design of bioimaging fluorescent probes by modulating the fluorescence properties of fluorophores, employing mechanisms such as acceptor-excited Photoinduced electron Transfer (a-PeT), donor-excited Photoinduced electron Transfer (d-PeT), and spirocyclization, which have been established by our group. The a-PeT and d-PeT mechanisms are widely applicable for the design of bioimaging probes based on many fluorophores and the spirocyclization process is also expected to be useful as a fluorescence off/on switching mechanism. Fluorescence modulation mechanisms are essential for the rational design of novel fluorescence probes for target molecules. Based on these mechanisms, we have developed more than fifty bioimaging probes, of which fourteen are commercially available. The review also describes some applications of the probes developed by our group to in vitro and in vivo systems

A Study of the \eta \pi^{0} Spectrum and Search for a J^{PC} = 1^{-+} Exotic Meson

A partial wave analysis (PWA) of the of the $\eta \pi ^0$ system (where $\eta \to \gamma \gamma$) produced in the charge exchange reaction $\pi ^-p\to \eta \pi ^0n$ at an incident momentum of 18 GeV$/c$ is presented as a function of ${\eta \pi ^0}$ invariant mass, $m_{\eta\pi^0}$, and momentum transfer squared, $t_{\pi^{-}\to\eta\pi}$, from the incident $\pi^-$ to the outgoing ${\eta\pi ^0}$ system. $S$, $P$ and $D$ waves were included in the PWA. The $a_0(980)$ and $a_2(1320)$ states are clearly observed in the overall ${\eta\pi ^0}$ effective mass distribution as well as in the amplitudes associated with $S$ wave and $D$ waves respectively after partial wave decomposition. The observed distributions in moments (averages of spherical harmonics) were compared to the results from the PWA and the two are consistent. The distribution in $t_{\pi^{-}\to\eta\pi}$ for individual $D$ waves associated with natural and unnatural parity exchange in the $t$-channel are consistent with Regge phenomenology. Of particular interest in this study is the $P$ wave since this leads to an exotic $J^{PC}=1^{-+}$ for the $\eta \pi$ system. A $P$ wave is present in the data, however attempts to describe the mass dependence of the amplitude and phase motion with respect to the $D$ wave as a Breit-Wigner resonance are problematic. This has implications regarding the existence of a reported exotic $J^{PC} = 1^{-+}$ meson decaying into $\eta \pi^0$ with a mass near 1.4 GeV$/c^2$.Comment: 19 pages, 29 figures, to appear in Phys. Rev.

What Do Patients Value in the Hospital Meal Experience?

A number of previous studies have reported on the aspects of hospital food service that patients value, but usually as a secondary finding, and not generally based upon patient-centred approaches. This study employed a questionnaire produced ab initio from interviews with patients and hospital staff, the data from which were subjected to factor and cluster analysis, in order to identify and prioritise the factors that contribute to the meal experience empirically. The most important factors, food and service were as identified by other authors. In decreasing order of importance were social, personal and situational factors. The results confirm that improving the quality of the food and the efficiency with which it reaches the patients remain the most important objectives of hospital food service

Microwave pyrolysis of olive pomace for bio-oil and bio-char production

Olive pomace is a widely available agro-industrial waste residue in Europe that has the potential to contribute towards a circular, low carbon bio-economy. This study demonstrated, for the first time, the ability to successfully pyrolyse olive pomace with microwaves for the production of bio-char and bio-oil. It was found that the energy requirement needed to pyrolyse up to 80% of the olive pomace was as low as 3.6 kJ/g and bio-oil yields up to 30% were produced. Microwave power did not influence the overall yields or the chemical composition of the obtained bio-oils, but did alter the textural properties of the generated bio-chars and their ability to remove methylene blue dye. Optimum processing conditions were found to be within the 3.6 kJ/g energy requirement with a microwave power of 200 W and processing time of 180 sec. These conditions produced a bio-oil fraction containing mainly acetic acid (71.9%) and a bio-char with a surface area of 392.3 m2/g, micropore volume of 0.15 cm3/g and a methylene blue removal efficiency of 40 qMB mg/g. The results acquired from this study reveal the superiority of microwave heating in a pyrolysis system and highlight a novel and prospective route for added value recovery from natural waste resources like olive pomace

Observation of a Narrow Resonance of Mass 2.46 GeV/c^2 Decaying to D_s^*+ pi^0 and Confirmation of the D_sJ^* (2317) State

Using 13.5 inverse fb of e+e- annihilation data collected with the CLEO II detector we have observed a narrow resonance in the Ds*+pi0 final state, with a mass near 2.46 GeV. The search for such a state was motivated by the recent discovery by the BaBar Collaboration of a narrow state at 2.32 GeV, the DsJ*(2317)+ that decays to Ds+pi0. Reconstructing the Ds+pi0 and Ds*+pi0 final states in CLEO data, we observe peaks in both of the corresponding reconstructed mass difference distributions, dM(Dspi0)=M(Dspi0)-M(Ds) and dM(Ds*pi0)=M(Ds*pi0)-M(Ds*), both of them at values near 350 MeV. We interpret these peaks as signatures of two distinct states, the DsJ*(2317)+ plus a new state, designated as the DsJ(2463)+. Because of the similar dM values, each of these states represents a source of background for the other if photons are lost, ignored or added. A quantitative accounting of these reflections confirms that both states exist. We have measured the mean mass differences = 350.0 +/- 1.2 [stat] +/- 1.0 [syst] MeV for the DsJ*(2317) state, and = 351.2 +/- 1.7 [stat] +/- 1.0 [syst] MeV for the new DsJ(2463)+ state. We have also searched, but find no evidence, for decays of the two states via the channels Ds*+gamma, Ds+gamma, and Ds+pi+pi-. The observations of the two states at 2.32 and 2.46 GeV, in the Ds+pi0 and Ds*+pi0 decay channels respectively, are consistent with their interpretations as (c anti-strange) mesons with orbital angular momentum L=1, and spin-parities of 0+ and 1+.Comment: 16 pages postscript, also available through http://w4.lns.cornell.edu/public/CLNS, version to be published in Physical Review D; minor modifications and fixes to typographical errors, plus an added section on production properties. The main results are unchanged; they supersede those reported in hep-ex/030501

Measurement of the Charge Asymmetry in B→K∗(892)±π∓B\to K^* (892)^{\pm}\pi^{\mp}

We report on a search for a CP-violating asymmetry in the charmless hadronic decay B -> K*(892)+- pi-+, using 9.12 fb^-1 of integrated luminosity produced at \sqrt{s}=10.58 GeV and collected with the CLEO detector. We find A_{CP}(B -> K*(892)+- pi-+) = 0.26+0.33-0.34(stat.)+0.10-0.08(syst.), giving an allowed interval of [-0.31,0.78] at the 90% confidence level.Comment: 7 pages postscript, also available through http://w4.lns.cornell.edu/public/CLNS, submitted to PR