Hot Routes: Developing a New Technique for the Spatial Analysis of Crime

The use of hotspot mapping techniques such as KDE to represent the geographical spread of linear events can be problematic. Network-constrained data (for example transport-related crime) require a different approach to visualize concentration. We propose a methodology called Hot Routes, which measures the risk distribution of crime along a linear network by calculating the rate of crimes per section of road. This method has been designed for everyday crime analysts, and requires only a Geographical Information System (GIS), and suitable data to calculate. A demonstration is provided using crime data collected from London bus routes

Interferometric Phase Calibration Sources in the Declination Range 0deg to -30deg

We present a catalog of 321 compact radio sources in the declination range 0deg > delta > -30deg. The positions of these sources have been measured with a two-dimensional rms accuracy of 35 milliarcseconds using the NRAO Very Large Array. Each source has a peak flux density >50 mJy at 8.4 GHz. We intend for this catalog to be used mainly for selection of phase calibration sources for radio interferometers, although compact radio sources have other scientific uses.Comment: 9 pages. To appear in ApJS. Catalog (Table 3) is abbreviated in printed version. Complete catalog available at ftp://ftp.aoc.nrao.edu/pub/staff/jwrobel/WPW2003_ApJS.tx

Synaptic Circuit Abnormalities of Motor-Frontal Layer 2/3 Pyramidal Neurons in an RNA Interference Model of Methyl-CpG-Binding Protein 2 Deficiency

Rett syndrome, an autism spectrum disorder with prominent motor and cognitive features, results from mutations in the gene for methyl-CpG-binding protein 2 (MeCP2). Here, to identify cortical circuit abnormalities that are specifically associated with MeCP2 deficiency, we used glutamate uncaging and laser scanning photostimulation to survey intracortical networks in mouse brain slices containing motor-frontal cortex. We used in utero transfection of short hairpin RNA constructs to knock down MeCP2 expression in a sparsely distributed subset of layer (L) 2/3 pyramidal neurons in wild-type mice, and compared input maps recorded from transfected-untransfected pairs of neighboring neurons. The effect of MeCP2 deficiency on local excitatory input pathways was severe, with an average reduction in excitatory synaptic input from middle cortical layers (L3/5A) of >30% compared with MeCP2-replete controls. MeCP2 deficiency primarily affected the strength, rather than the topography, of excitatory intracortical pathways. Inhibitory synaptic inputs and intrinsic eletrophysiological properties were unaffected in the MeCP2-knockdown neurons. These studies indicate that MeCP2 deficiency in individual postsynaptic cortical pyramidal neurons is sufficient to induce a pathological synaptic defect in excitatory intracortical circuits

In the Shadow of the Accretion Disk: Higher Resolution Imaging of the Central Parsec in NGC 4261

The physical conditions in the inner parsec of accretion disks believed to orbit the central black holes in active galactic nuclei can be probed by imaging the absorption (by ionized gas in the disk) of background emission from a radio counterjet. We report high angular resolution VLBI observations of the nearby (about 40 Mpc) radio galaxy NGC 4261 that confirm free-free absorption of radio emission from a counterjet by a geometrically thin, nearly edge-on disk at 1.6, 4.8, and 8.4 GHz. The angular width and depth of the absorption appears to increase with decreasing frequency, as expected. We derive an average electron density of ~10E4 per cc at a disk radius of about 0.2 pc, assuming that the inner disk inclination and opening angles are the same as at larger radii. Pressure balance between the thermal gas and the magnetic field in the disk implies an average field strength of 0.1 milligauss at a radius of 0.2 pc. These are the closest-in free-free absorption measurements to date of the conditions in an extragalactic accretion disk orbiting a black hole with a well-determined mass. If a standard advection-dominated accretion flow exists in the disk center, then the transition between thin and thick disk regions must occur at a radius less than 0.2 pc (4000 Schwarzschild radii).Comment: 20 pages including 12 figures. Accepted for publication in Ap

VSOP observation of the quasar PKS 2215+020: a new laboratory for core-jet physics at z=3.572

We report results of a VSOP (VLBI Space Observatory Programme) observation of a high redshift quasar PKS 2215+020 (z=3.572). The ~1 milliarcsecond resolution image of the quasar reveals a prominent `core-jet' structure on linear scales from 5/h to 300/h pc ($H_0=100*h km/(s*Mpc). The brightness temperatures and sizes of bright features identified in the jet are consistent with emission from relativistic shocks dominated by adiabatic energy losses. The jet is powered by the central black hole with estimated mass of ~4*10^9 solar masses. Comparisons with VLA and ROSAT observations indicate a possible presence of an extended radio/X-ray halo surrounding 2215+020.Comment: 15 pages, 6 figures, aastex macros; accepted for publication in The Astrophysical Journal, V.546, N.2 *(January 10 2001

PMN J1632-0033: A new gravitationally lensed quasar

We report the discovery of a gravitationally lensed quasar resulting from our survey for lenses in the southern sky. Radio images of PMN J1632-0033 with the VLA and ATCA exhibit two compact, flat-spectrum components with separation 1.47" and flux density ratio 13.2. Images with the HST reveal the optical counterparts to the radio components and also the lens galaxy. An optical spectrum of the bright component, obtained with the first Magellan telescope, reveals quasar emission lines at redshift 3.42. Deeper radio images with MERLIN and the VLBA reveal a faint third radio component located near the center of the lens galaxy, which is either a third image of the background quasar or faint emission from the lens galaxy.Comment: 21 pp., including 4 figures; thoroughly revised in light of new MERLIN/HST data; accepted for publication in A

Can consumers learn to ask three questions to improve shared decision making? A feasibility study of the ASK (AskShareKnow) Patient–Clinician Communication Model® intervention in a primary health-care setting

Funded by Informed Medical Decisions Foundation. Grant Number: #0175-1 National Health and Medical Research Council Public Health Training Fellowship. Grant Number: 568962Peer reviewedPublisher PD

The molecular genetic analysis of the expanding pachyonychia congenita case collection

BACKGROUND: Pachyonychia congenita (PC) is a rare autosomal dominant keratinizing disorder characterized by severe, painful, palmoplantar keratoderma and nail dystrophy, often accompanied by oral leucokeratosis, cysts and follicular keratosis. It is caused by mutations in one of five keratin genes: KRT6A, KRT6B, KRT6C, KRT16 or KRT17. OBJECTIVES: To identify mutations in 84 new families with a clinical diagnosis of PC, recruited by the International Pachyonychia Congenita Research Registry during the last few years. METHODS: Genomic DNA isolated from saliva or peripheral blood leucocytes was amplified using primers specific for the PC-associated keratin genes and polymerase chain reaction products were directly sequenced. RESULTS: Mutations were identified in 84 families in the PC-associated keratin genes, comprising 46 distinct keratin mutations. Fourteen were previously unreported mutations, bringing the total number of different keratin mutations associated with PC to 105. CONCLUSIONS: By identifying mutations in KRT6A, KRT6B, KRT6C, KRT16 or KRT17, this study has confirmed, at the molecular level, the clinical diagnosis of PC in these families

The Radio Afterglow From GRB 980519: A Test of the Jet and Circumstellar Models

We present multi-frequency radio observations from the afterglow of GRB 980519 beginning 7.2 hours after the gamma-ray burst and ending 63 days later. The fast decline in the optical and X-ray light curves for this burst has been interpreted either as afterglow emission originating from a collimated outflow -- a jet -- or the result of a blast wave propagating into a medium whose density is shaped by the wind of an evolved massive star. These two models predict divergent behavior for the radio afterglow, and therefore, radio observations are capable, in principle, of discriminating between the two. We show that a wind model describes the subsequent evolution of the radio afterglow rather well. However, we see strong modulation of the light curve, which we interpret as diffractive scintillation. These variations prevent us from decisively rejecting the jet model.Comment: ApJ, submitte