Envisioning the South End of Tomorrow: Live, Work and Recreate in a Transforming Neighborhood

ENVISIONING THE SOUTH END OF TOMORROW – Live, Work and Recreate in a Transforming Neighborhood Background and Challenges Downtown Springfield is currently undergoing a substantial change of the physical urban fabric. The most visible examples are the construction of the MGM Casino Resort and the renovated Union Station into a multimodal transportation hub. The MGM Casino Resort is the first one in the country that is integrated in a core downtown area. It is obvious that downtown and its adjacent districts will change substantially. How can different uses next to each other coexist productively or can negative influences be being mitigated? How can people that live in the South End benefit from urban development? Will their neighborhood become a healthier, more beautiful and more social place? How can the South End maintain its diversity while obtaining more space for expressing culture in a positive way? Method This design studio was a community service learning experience with goals and objectives that derived from informal interviews with people on the streets, stakeholder meetings, personal observations, sketching and case study research. The design solutions can be synthesized with these recommendations: Project Goals: • Create a multi-scalar greenway system for the whole neighborhood that creates a network of green squares and green streets. • Plant big street trees throughout the neighborhood to filter air and make the streets more walkable. • Create a system small places to sit and gather. • Redesign residential streets that prioritizes bicycle and foot traffic. • Create pedestrian crossings for Main Street and East Columbus Avenue to slow traffic down. • Design East and West Columbus Avenue as pedestrian-and bicycle-friendly corridors through a road diet and speed reduction. • Foster Connections underneath I-91 and across the Railroad to engage the Connecticut River and the Riverfront Park. • Create infill development on Main Street that supports local commerce and services. • Use vacant lots in the neighborhood for new housing that is green, innovative and attractive for diverse demographics. • Reduce the impact of stormwater runoff through swales along streets and underused land. • Address the diversity in the neighborhood and embrace the diversity of cultures through visual and performative art and ethnic food. Project Significance: This studio will advise the City of Springfield mitigating the impact of the casino through the media of Landscape Architecture

Heritage Quay: What Will You Discover? Transforming the Archives of the University of Huddersfield, Yorkshire, UK

The Heritage Quay project is changing how archive services at the University of Huddersfield are delivered. This article examines how the Staff/Space/Collections dependency model and Customer Service Excellence framework have been used, and what lessons can be drawn for other archives

Cross-Dimensional Mapping of Number, Length and Brightness by Preschool Children

Human adults in diverse cultures, children, infants, and non-human primates relate number to space, but it is not clear whether this ability reflects a specific and privileged number-space mapping. To investigate this possibility, we tested preschool children in matching tasks where the dimensions of number and length were mapped both to one another and to a third dimension, brightness. Children detected variation on all three dimensions, and they reliably performed mappings between number and length, and partially between brightness and length, but not between number and brightness. Moreover, children showed reliably better mapping of number onto the dimension of length than onto the dimension of brightness. These findings suggest that number establishes a privileged mapping with the dimension of length, and that other dimensions, including brightness, can be mapped onto length, although less efficiently. Children's adeptness at number-length mappings suggests that these two dimensions are intuitively related by the end of the preschool years

Inarticulate devices: Critical encounters with network technology in research through design

Research through design (RTD) is commonly conceived as a material and discursive practice of articulating knowledge. This paper contributes to the understanding of RTD as a form of critical inquiry by considering how inarticulacy can also be a productive element of this process. We present two reflective accounts of critically-engaged RTD practices in which our attempts to articulate concerns or questions were met with resistance from technology that was both the subject and medium of our investigation. We argue that encountering inarticulacy is not a failure of RTD but instead points to how material exploration can sensitise us to how network technology resists articulating certain values or concerns. Encountering inarticulacy led us to formulate new problems and new lines of inquiry. We conclude by suggesting that the central role given to ambiguity in RTD prepares us to witness and respond to inarticulacy in our practices, design outcomes and critical understandings

Jazz Convocation

Program listing performers and works performed

Estimating Individual Exposure to Malaria Using Local Prevalence of Malaria Infection in the Field

BACKGROUND: Heterogeneity in malaria exposure complicates survival analyses of vaccine efficacy trials and confounds the association between immune correlates of protection and malaria infection in longitudinal studies. Analysis may be facilitated by taking into account the variability in individual exposure levels, but it is unclear how exposure can be estimated at an individual level. METHOD AND FINDINGS: We studied three cohorts (Chonyi, Junju and Ngerenya) in Kilifi District, Kenya to assess measures of malaria exposure. Prospective data were available on malaria episodes, geospatial coordinates, proximity to infected and uninfected individuals and residence in predefined malaria hotspots for 2,425 individuals. Antibody levels to the malaria antigens AMA1 and MSP1(142) were available for 291 children from Junju. We calculated distance-weighted local prevalence of malaria infection within 1 km radius as a marker of individual's malaria exposure. We used multivariable modified Poisson regression model to assess the discriminatory power of these markers for malaria infection (i.e. asymptomatic parasitaemia or clinical malaria). The area under the receiver operating characteristic (ROC) curve was used to assess the discriminatory power of the models. Local malaria prevalence within 1 km radius and AMA1 and MSP1(142) antibodies levels were independently associated with malaria infection. Weighted local malaria prevalence had an area under ROC curve of 0.72 (95%CI: 0.66-0.73), 0.71 (95%CI: 0.69-0.73) and 0.82 (95%CI: 0.80-0.83) among cohorts in Chonyi, Junju and Ngerenya respectively. In a small subset of children from Junju, a model incorporating weighted local malaria prevalence with AMA1 and MSP1(142) antibody levels provided an AUC of 0.83 (95%CI: 0.79-0.88). CONCLUSION: We have proposed an approach to estimating the intensity of an individual's malaria exposure in the field. The weighted local malaria prevalence can be used as individual marker of malaria exposure in malaria vaccine trials and longitudinal studies of natural immunity to malaria

The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Development

BACKGROUND: Int-6 (integration site 6) was identified as an oncogene in a screen of tumorigenic mouse mammary tumor virus (MMTV) insertions. INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physiological function has been lacking. PRINCIPAL FINDINGS: Here, we create an in vivo model of Int6 function in zebrafish, and through genetic and chemical-genetic approaches implicate Int6 as a tissue-specific modulator of MEK-ERK signaling. We find that Int6 is required for normal expression of MEK1 protein in human cells, and for Erk signaling in zebrafish embryos. Loss of either Int6 or Mek signaling causes defects in craniofacial development, and Int6 and Erk-signaling have overlapping domains of tissue expression. SIGNIFICANCE: Our results provide new insight into the physiological role of vertebrate Int6, and have implications for the treatment of human tumors displaying altered INT6 expression

Conference of Microelectronics Research 2002

https://scholarworks.rit.edu/meec_archive/1011/thumbnail.jp

Integrin CD11b activation drives anti-tumor innate immunity

Myeloid cells are recruited to damaged tissues where they can resolve infections and tumor growth or stimulate wound healing and tumor progression. Recruitment of these cells is regulated by integrins, a family of adhesion receptors that includes integrin CD11b. Here we report that, unexpectedly, integrin CD11b does not regulate myeloid cell recruitment to tumors but instead controls myeloid cell polarization and tumor growth. CD11b activation promotes pro-inflammatory macrophage polarization by stimulating expression of microRNA Let7a. In contrast, inhibition of CD11b prevents Let7a expression and induces cMyc expression, leading to immune suppressive macrophage polarization, vascular maturation, and accelerated tumor growth. Pharmacological activation of CD11b with a small molecule agonist, Leukadherin 1 (LA1), promotes pro-inflammatory macrophage polarization and suppresses tumor growth in animal models of murine and human cancer. These studies identify CD11b as negative regulator of immune suppression and a target for cancer immune therapy