Virtual image out-the-window display system study. Volume 2 - Appendix

Virtual image out-the-window display system imaging techniques and simulation devices - appendices containing background materia

Occurrence of an Ocean Sunfish (Mola mola) Larva in the Florida Current

During a yearlong ichthyoplankton survey conducted in the Florida Current, a single ocean sunfish, Mola mola, was found from the 284 samples and 1,454 identified specimens. This sunfish larva is one of only 17 on record from the Gulf of Mexico and northwest Atlantic

Lymphoid Susceptibility to the Aggregatibacter Actinomycetemcomitans Cytolethal Distending Toxin is Dependent Upon Baseline Levels of the Signaling Lipid, Phosphatidylinositol-3,4,5-Triphosphate

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes and other cell types. We have shown that the active subunit, CdtB, exhibits phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase activity and depletes lymphoid cells of PIP3. Hence we propose that Cdt toxicity results from depletion of this signaling lipid and perturbation of phosphatidylinositol-3-kinase (PI-3K)/PIP3/Akt signaling. We have now focused on the relationship between cell susceptibility to CdtB and differences in the status of baseline PIP3 levels. Our studies demonstrate that the baseline level of PIP3, and likely the dependence of cells on steady-state activity of the PI-3K signaling pathway for growth and survival, influence cell susceptibility to the toxic effects of Cdt. Jurkat cells with known defects in both PIP3 degradative enzymes, PTEN and SHIP1, not only contain high baseline levels of PIP3, pAkt, and pGSK3β, but also exhibit high sensitivity to Cdt. In contrast, HUT78 cells, with no known defects in this pathway, contain low levels of PIP3, pAkt, and pGSK3β and likely minimal dependence on the PI-3K signaling pathway for growth and survival, and exhibit reduced susceptibility to Cdt. These differences in susceptibility to Cdt cannot be explained by differential toxin binding or internalization of the active subunit. Indeed, we now demonstrate that Jurkat and HUT78 cells bind toxin at comparable levels and internalize relatively equal amounts of CdtB. The relevance of these observations to the mode of action of Cdt and its potential role as a virulence factor isdiscussed. © 2016 John Wiley & Sons A/S

Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study

A41 Use of SMS texts for facilitating access to online alcohol interventions: a feasibility study In: Addiction Science & Clinical Practice 2017, 12(Suppl 1): A4

Optimal Resource Allocation in Random Networks with Transportation Bandwidths

We apply statistical physics to study the task of resource allocation in random sparse networks with limited bandwidths for the transportation of resources along the links. Useful algorithms are obtained from recursive relations. Bottlenecks emerge when the bandwidths are small, causing an increase in the fraction of idle links. For a given total bandwidth per node, the efficiency of allocation increases with the network connectivity. In the high connectivity limit, we find a phase transition at a critical bandwidth, above which clusters of balanced nodes appear, characterised by a profile of homogenized resource allocation similar to the Maxwell's construction.Comment: 28 pages, 11 figure

Making predictions in the multiverse

I describe reasons to think we are living in an eternally inflating multiverse where the observable "constants" of nature vary from place to place. The major obstacle to making predictions in this context is that we must regulate the infinities of eternal inflation. I review a number of proposed regulators, or measures. Recent work has ruled out a number of measures by showing that they conflict with observation, and focused attention on a few proposals. Further, several different measures have been shown to be equivalent. I describe some of the many nontrivial tests these measures will face as we learn more from theory, experiment, and observation.Comment: 20 pages, 3 figures; invited review for Classical and Quantum Gravity; v2: references improve

M Theory As A Matrix Model: A Conjecture

We suggest and motivate a precise equivalence between uncompactified eleven dimensional M-theory and the N = infinity limit of the supersymmetric matrix quantum mechanics describing D0-branes. The evidence for the conjecture consists of several correspondences between the two theories. As a consequence of supersymmetry the simple matrix model is rich enough to describe the properties of the entire Fock space of massless well separated particles of the supergravity theory. In one particular kinematic situation the leading large distance interaction of these particles is exactly described by supergravity . The model appears to be a nonperturbative realization of the holographic principle. The membrane states required by M-theory are contained as excitations of the matrix model. The membrane world volume is a noncommutative geometry embedded in a noncommutative spacetime.Comment: Typo and tex error corrected. 41 pages, harvma

Phases of Josephson Junction Ladders

We study a Josephson junction ladder in a magnetic field in the absence of charging effects via a transfer matrix formalism. The eigenvalues of the transfer matrix are found numerically, giving a determination of the different phases of the ladder. The spatial periodicity of the ground state exhibits a devil's staircase as a function of the magnetic flux filling factor $f$. If the transverse Josephson coupling is varied a continuous superconducting-normal transition in the transverse direction is observed, analogous to the breakdown of the KAM trajectories in dynamical systems.Comment: 12 pages with 3 figures, REVTE

The Trouble with de Sitter Space

In this paper we assume the de Sitter Space version of Black Hole Complementarity which states that a single causal patch of de Sitter space is described as an isolated finite temperature cavity bounded by a horizon which allows no loss of information. We discuss the how the symmetries of de Sitter space should be implemented. Then we prove a no go theorem for implementing the symmetries if the entropy is finite. Thus we must either give up the finiteness of the de Sitter entropy or the exact symmetry of the classical space. Each has interesting implications for the very long time behavior. We argue that the lifetime of a de Sitter phase can not exceed the Poincare recurrence time. This is supported by recent results of Kachru, Kallosh, Linde and Trivedi.Comment: 15 pages, 1 figure. v2: added fifth section with comments on long time stability of de Sitter space, in which we argue that the lifetime can not exceed the Poincare recurrence time. v3: corrected a minor error in the appendi

The 1/D Expansion for Classical Magnets: Low-Dimensional Models with Magnetic Field

The field-dependent magnetization m(H,T) of 1- and 2-dimensional classical magnets described by the $D$-component vector model is calculated analytically in the whole range of temperature and magnetic fields with the help of the 1/D expansion. In the 1-st order in 1/D the theory reproduces with a good accuracy the temperature dependence of the zero-field susceptibility of antiferromagnets \chi with the maximum at T \lsim |J_0|/D (J_0 is the Fourier component of the exchange interaction) and describes for the first time the singular behavior of \chi(H,T) at small temperatures and magnetic fields: \lim_{T\to 0}\lim_{H\to 0} \chi(H,T)=1/(2|J_0|)(1-1/D) and \lim_{H\to 0}\lim_{T\to 0} \chi(H,T)=1/(2|J_0|)