Local variance of atmospheric 14C concentrations around Fukushima Dai-ichi Nuclear Power Plant from 2010 to 2012

Radiocarbon (14C) has been measured in single tree ring samples collected from the southwest of the Fukushima Dai-ichi Nuclear Power Plant. Our data indicate south-westwards dispersion of radiocarbon and the highest 14C activity observed so far in the local environment during the 2011 accident. The abnormally high 14C activity in the late wood of 2011 ring may imply an unknown source of radiocarbon nearby after the accident. The influence of 14C shrank from 30 km during normal reactor operation to 14 km for the accident in the northwest of FDNPP, but remains unclear in the southwest

Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis.

Aberrant activation of the Rb/E2F1 pathway in cycling cells, in response to mitogenic or nonmitogenic stress signals, leads to apoptosis through hyperphosphorylation of Rb. To test whether in postmitotic neurons the Rb/E2F1 pathway can be activated by the nonmitogenic stress signaling, we examined the role of the p38 stress-activated protein kinase (SAPK) in regulating Rb phosphorylation in response to Fas (CD95/APO1)-mediated apoptosis of cultured cerebellar granule neurons (CGNs). Anti-Fas antibody induced a dramatic and early activation of p38. Activated p38 was correlated with the induction of hyperphosphorylation of both endogenous and exogenous Rb. The p38-selective inhibitor, SB203580, attenuated such an increase in pRb phosphorylation and significantly protected CGNs from Fas-induced apoptosis. The cyclin-dependent kinase-mediated Rb phosphorylation played a lesser role in this neuronal death paradigm, since cyclin-dependent kinase inhibitors, such as olomoucine, roscovitine, and flavopiridol, did not significantly prevent anti-Fas antibody-evoked neuronal apoptosis. Hyperphosphorylation of Rb by p38 SAPK resulted in the release of Rb-bound E2F1. Increased E2F1 modulated neuronal apoptosis, since E2F1-/- CGNs were significantly less susceptible to Fas-mediated apoptosis in comparison with the wild-type CGNs. Taken together, these studies demonstrate that neuronal Rb/E2F1 is modulated by the nonproliferative p38 SAPK in Fas-mediated neuronal apoptosis

Radiocarbon releases from the 2011 Fukushima nuclear accident

Radiocarbon activities were measured in annual tree rings for the years 2009 to 2015 from Japanese cedar trees (Cryptomeria japonica) collected at six sites ranging from 2.5–38 km northwest and north of the Fukushima Dai-ichi nuclear power plant. The 14C specific activity varied from 280.4 Bq kg−1 C in 2010 to 226.0 Bq kg−1 C in 2015. The elevated 14C activities in the 2009 and 2010 rings confirmed 14C discharges during routine reactor operations, whereas those activities that were indistinguishable from background in 2012–2015 coincided with the permanent shutdown of the reactors after the accident in 2011. High-resolution 14C analysis of the 2011 ring indicated 14C releases during the Fukushima accident. The resulted 14C activity decreased with increasing distance from the plant. The maximum 14C activity released during the period of the accident was measured 42.4 Bq kg−1 C above the natural ambient 14C background. Our findings indicate that, unlike other Fukushima-derived radionuclides, the 14C released during the accident is indistinguishable from ambient background beyond the local environment (~30 km from the plant). Furthermore, the resulting dose to the local population from the excess 14C activities is negligible compared to the dose from natural/nuclear weapons sources

Re-colonizing spaces of memorializing: the case of the Chattri Indian Memorial, UK

This article inspects the ways that spaces of war memorialization are organized and reorganized through official and unofficial meaning-making activities. It aims to contribute to the discussion of the ‘value’ of memorializing by examining a multifaceted space of remembrance and commemoration: the Chattri Indian Memorial built near Brighton, UK. The article brings postcolonial perspectives to explore how memorializing has been organized here, focusing on the activities of once-colonized people and the affective, embodied aspects of organizing practices. Built in 1921 to honour Indian soldiers who fought in WWI, the Chattri evolved from a colonial instrument to symbol and space for ethnic-Indian group activities. The study employed historical, visual and ethnographic methods to study the tangible monument and the changing nature of the memorializing activities carried out around the monument. Memorializing is conceptualized within three inter-related processes: colonizing, de-colonizing and re-colonizing to examine how forms and practices of memorialization constitute a values-laden organizing system

Imaging Mass Spectrometry Detection of Gangliosides Species Within the Mouse Brain Following Transient Focal Cerebral Ischemia

Gangliosides, a member of the glycosphingolipid family, are heterogeneously expressed in biological membranes and are particularly enriched within the central nervous system. Gangliosides consist of mono- or poly-sialylated oligosaccharide chains of variable lengths attached to a ceramide unit and are found to be intimately involved in brain disease development. The purpose of this study is to examine the spatial profile of ganglioside species using matrix-assisted laser desorption/ionization (MALDI) imaging (IMS) following middle cerebral artery occlusion (MCAO) reperfusion injury in the mouse. IMS is a powerful method to not only discriminate gangliosides by their oligosaccharide components, but also by their carbon length within their sphingosine base. Mice were subjected to a 30 min unilateral MCAO followed by long-term survival (up to 28 days of reperfusion). Brain sections were sprayed with the matrix 5-Chloro-2-mercaptobenzothiazole, scanned and analyzed for a series of ganglioside molecules using an Applied Biosystems 4800 MALDI TOF/TOF. Traditional histological and immunofluorescence techniques were performed to assess brain tissue damage and verification of the expression of gangliosides of interest. Results revealed a unique anatomical profile of GM1, GD1 and GT1b (d18∶1, d20∶1 as well as other members of the glycosphingolipid family). There was marked variability in the ratio of expression between ipsilateral and contralateral cortices for the various detected ganglioside species following MCAO-reperfusion injury. Most interestingly, MCAO resulted in the transient induction of both GM2 and GM3 signals within the ipsilateral hemisphere; at the border of the infarcted tissue. Taken together, the data suggest that brain region specific expression of gangliosides, particularly with respect to hydrocarbon length, may play a role in neuronal responses to injury

Chlortetracycline and Demeclocycline Inhibit Calpains and Protect Mouse Neurons against Glutamate Toxicity and Cerebral Ischemia

Minocycline is a potent neuroprotective tetracycline in animal models of cerebral ischemia. We examined the protective properties of chlortetracycline (CTC) and demeclocycline (DMC) and showed that these two tetracyclines were also potent neuroprotective against glutamate-induced neuronal death in vitro and cerebral ischemia in vivo. However, CTC and DMC appeared to confer neuroprotection through a unique mechanism compared with minocycline. Rather than inhibiting microglial activation and caspase, CTC and DMC suppressed calpain activities. In addition, CTC and DMC only weakly antagonized N-methyl-D-aspartate (NMDA) receptor activities causing 16 and 14%, respectively, inhibition of NMDA-induced whole cell currents and partially blocked NMDA-induced Ca2+ influx, commonly regarded as the major trigger of neuronal death. In vitro and in vivo experiments demonstrated that the two compounds selectively inhibited the activities of calpain I and II activated following glutamate treatment and cerebral ischemia. In contrast, minocycline did not significantly inhibit calpain activity. Taken together, these results suggested that CTC and DMC provide neuroprotection through suppression of a rise in intracellular Ca2+ and inhibition of calpains

Electroweak radiative corrections to e+e−→ttˉhe^+e^- \to t \bar{t} h at linear colliders

We calculate the ${\cal O}(\alpha_{{\rm ew}})$ electroweak radiative corrections to $e^+ e^- \to t \bar{t} h$ at a electron-positron linear collider (LC) in the standard model. We analyze the dependence of the ${\cal O}(\alpha_{{\rm ew}})$ corrections on the Higgs boson mass $m_{h}$ and colliding energy $\sqrt{s}$, and find that the corrections significantly decrease or increase the Born cross section depending on the colliding energy. The numerical results show that the ${\cal O}(\alpha_{{\rm ew}})$ relative correction is strongly related to the Higgs boson mass when $\sqrt{s}=500 GeV$, and for $m_h = 150 GeV$ the relative correction ranges from -31.3% to 2.3% as the increment of the colliding energy from 500 GeV to 2 TeV.Comment: 16 pages, 7 figure

CP-Violation For B→Xsl+l−B \to X_sl^+l^- Including Long-Distance Effects

We consider the CP violating effect for $B\to X_sl^+l^-$ process, including both short and long distance effects. We obtain the CP asymmetry parameter and present its variation over the dilepton mass.Comment: 9 pages, Latex file, one figure include

O(αs){\cal O}(\alpha_{s}) QCD and O(αew){\cal O}(\alpha_{ew}) electroweak corrections to ttˉh0t\bar{t}h^0 production in γγ\gamma \gamma collision

We calculate the ${\cal O}(\alpha_{s})$ QCD and ${\cal O}(\alpha_{{\rm ew}})$ electroweak one-loop corrections in the Standard Model framework, to the production of an intermediate Higgs boson associated with $t\bar{t}$ pair via $\gamma \gamma$ fusion at an electron-positron linear collider (LC). We find the ${\cal O}(\alpha_{s})$ QCD corrections can be larger than the ${\cal O}(\alpha_{{\rm ew}})$ electroweak ones, with the variations of the Higgs boson mass $m_{h}$ and $e^+e^-$ colliding energy $\sqrt{s}$. Both corrections may significantly decrease or increase the Born cross section. The numerical results show that the relative corrections from QCD to the process \eep may reach 34.8%, when $\sqrt{s}=800$ GeV and $m_h=200$ GeV, while those from electroweak can be -13.1%, -15.8% and -12.0%, at $\sqrt{s} = 800$ GeV, 1 TeV and 2 TeV respectively.Comment: 38 pages, 16 figure

Pseudoscalar Higgs boson production associated with a single bottom quark at hadron colliders

We compute the complete next-to-leading order (NLO) SUSY-QCD corrections for the associated production of a pseudoscalar Higgs boson with a bottom quark via bottom-gluon fusion at the CERN Large Hadron Collider (LHC) and the Fermilab Tevatron. We find that the NLO QCD correction in the MSSM reaches $40$ at the LHC and $45$ at the Tevatron in our chosen parameter space