Latest Observational Constraints to the Ghost Dark Energy Model by Using Markov Chain Monte Carlo Approach

Recently, the vacuum energy of the QCD ghost in a time-dependent background is proposed as a kind of dark energy candidate to explain the acceleration of the universe. In this model, the energy density of the dark energy is proportional to the Hubble parameter $H$, which is the Hawking temperature on the Hubble horizon of the Friedmann-Robertson-Walker (FRW) universe. In this paper, we perform a constraint on the ghost dark energy model with and without bulk viscosity, by using the Markov Chain Monte Carlo (MCMC) method and the combined latest observational data from the type Ia supernova compilations including Union2.1(580) and Union2(557), cosmic microwave background, baryon acoustic oscillation, and the observational Hubble parameter data.Comment: 12 pages, 4 figure

Thermodynamic of the Ghost Dark Energy Universe

Recently, the vacuum energy of the QCD ghost in a time-dependent background is proposed as a kind of dark energy candidate to explain the acceleration of the Universe. In this model, the energy density of the dark energy is proportional to the Hubble parameter $H$, which is the Hawking temperature on the Hubble horizon of the Friedmann-Robertson-Walker (FRW) Universe. In this paper, we generalized this model and choice the Hawking temperature on the so-called trapping horizon, which will coincides with the Hubble temperature in the context of flat FRW Universe dominated by the dark energy component. We study the thermodynamics of Universe with this kind of dark energy and find that the entropy-area relation is modified, namely, there is an another new term besides the area term.Comment: 8 pages, no figure

A 1-hydroxy-2,4-diformylnaphthalene-based fluorescent probe and its detection of sulfites/bisulfite

A novel 1-hydroxy-2,4-diformylnaphthalene-based fluorescent probe L was synthesized by a Knoevenagel reaction and exhibited excellent sensitivity and selectivity towards sulfite ions (SO32−) and bisulfite ions (HSO3−). The detection limits of the probe L were 0.24 μM using UV-Vis spectroscopy and 9.93 nM using fluorescence spectroscopy, respectively. Furthermore, the fluorescent probe L could be utilized for detection in real water samples with satisfactory recoveries in the range 99.20%~104.30% in lake water and 100.00%~104.80% in tap water by UV-Vis absorption spectrometry, and in the range 100.50%~108.60% in lake water and 102.70%~103.80% in tap water by fluorescence spectrophotometry

SENP1 regulates IFN-γ−STAT1 signaling through STAT3−SOCS3 negative feedback loop

Interferon-γ (IFN-γ) triggers macrophage for inflammation response by activating the intracellular JAK−STAT1 signaling. Suppressor of cytokine signaling 1 (SOCS1) and protein tyrosine phosphatases can negatively modulate IFN-γ signaling. Here, we identify a novel negative feedback loop mediated by STAT3−SOCS3, which is tightly controlled by SENP1 via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B), in IFN-γ signaling. SENP1-deficient macrophages show defects in IFN-γ signaling and M1 macrophage activation. PTP1B in SENP1-deficient macrophages is highly SUMOylated, which reduces PTP1B-induced de-phosphorylation of STAT3. Activated STAT3 then suppresses STAT1 activation via SOCS3 induction in SENP1-deficient macrophages. Accordingly, SENP1-deficient macrophages show reduced ability to resist Listeria monocytogenes infection. These results reveal a crucial role of SENP1-controlled STAT1 and STAT3 balance in macrophage polarization

A Turn-On Fluorescent Chemosensor for Cyanide Ion Detection in Real Water Samples

We have designed and synthesized a novel simple colorimetric fluorescent probe with aggregation-induced emission (AIE) properties. Probe 5-(4-(diphenylamine)phenyl) thiophen-2-formaldehyde W exhibited a turn-on fluorescent response to cyanide ion (CN−), which induces distinct visual color changes. Probe W exhibited a highly selective and sensitive ratiometric fluorescence response for the detection of CN− over a wide pH range (4–11) and in the presence of common interferents. The linear detection of CN− over the concentration range of 4.00–38.00 µM (R2 = 0.9916, RSD = 0.02) was monitored by UV-Vis absorption spectrometry (UV-Vis) with the limit of detection determined to be 0.48 µM. The linear detection of CN− over the concentration range of 8.00–38.00 µM was examined by fluorescence spectrophotometry (R2 = 0.99086, RSD = 0.031), and the detection limit was found to be 68.00 nM. The sensing mechanisms were confirmed by 1H NMR spectroscopic titrations, X-ray crystallographic analysis, and HRMS. Importantly, probe W was found to show rapid response, high selectivity, and sensitivity for cyanide anions in real water samples, over the range of 100.17∼100.86% in artificial lake water and 100.54∼101.64% in running water by UV-Vis absorption spectrometry, and over the range of 99.42∼100.71% in artificial lake water and 100.59∼101.17% in running water by fluorescence spectrophotometry. Importantly, this work provides a simple and effective approach which uses an economically cheap and uncomplicated synthetic route for the selective, sensitive, and quantitative detection of CN− ions in systems relevant to the environment and health

Tandem Michael addition/ylide epoxidation for the synthesis of highly functionalized cyclohexadiene epoxide derivatives

A highly efficient diastereoselective synthesis of cyclohexadiene epoxide derivatives with a multi-stereocenter has been developed via a tandem ylide Michael addition/epoxidation. By employing a chiral sulfonium ylide, up to 96% ee can be achieved in good yields