THE IMMEDIATE EFFECT OF A GENTLE HEEL STRIKE ON PERONEAL MUSCLE PRE-LANDING ACTIVATION DURING PROLONGED TREADMILL RUNNING IN MALES

Ankle sprains are common in runners. Inactive peroneal longus (PL) is one of the main contributors. The aim of this project was to study the immediate effect of running with a gentle heel strike (GHS) on pre-landing activation of the PL. It was hypothesised that GHS would pre-activate the PL to a greater extent. 11 healthy participants partook in two separate trials. The first involved running on a force plate treadmill with normally, the second with ~70% of mean heel pressure (MHP). GHS showed higher pre-landing PL activated level. There was data showing significant differences between groups at multiple timepoints. The present study showed that running with ~70% MHP compared with 100% increased PL activation for pre-landing phases. Further study should be implemented to see the fatigue level of PL during pro-longed running when running gently

SELECTING ADS RELEVANT TO LIVE EVENTS TO AN ONLINE AUDIENCE

If an advertiser wants to select ads for an online audience for a relevant event, the selection and audience specifications need to be manually created. Advertisers have to find the set of relevant keywords, a specified audience for the event , and an event time window, in order to create the ad campaign for their ads to show during the event. This manual process can be complex and time consuming, and advertisers may not be able to determine the right selection criteria or audience for the event. Furthermore, while some events may be identified well in advance, advertisers may not react as quickly to new events that are relevant to their ads. Additionally, advertisers may not be able to determine a proper window for presenting the ad. A search provider may be able to provide live, real-time answers for search queries related to live events that users are interested in, such as sports, weather, finance, movie show times, and more

Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation.

Inadequate dietary Zn consumption increases susceptibility to esophageal and other cancers in humans and model organisms. Since Zn supplementation can prevent cancers in rodent squamous cell carcinoma (SCC) models, we were interested in determining if it could have a preventive effect in a rodent skin cancer model, as a preclinical basis for considering a role for Zn in prevention of human nonmelanoma skin cancers, the most frequent cancers in humans. We used the 7,12-dimethyl benzanthracene carcinogen/phorbol myristate acetate tumor promoter treatment method to induce skin tumors in Zn-sufficient wild-type and Fhit (human or mouse protein) knockout mice. Fhit protein expression is lost in \u3e50% of human cancers, including skin SCCs, and Fhit-deficient mice show increased sensitivity to carcinogen induction of tumors. We hypothesized that: (1) the skin cancer burdens would be reduced by Zn supplementation; (2) Fhit(-/-) (Fhit, murine fragile histidine triad gene) mice would show increased susceptibility to skin tumor induction versus wild-type mice. 30 weeks after initiating treatment, the tumor burden was increased ~2-fold in Fhit(-/-) versus wild-type mice (16.2 versus 7.6 tumors, P \u3c 0.001); Zn supplementation significantly reduced tumor burdens in Fhit(-/-) mice (males and females combined, 16.2 unsupplemented versus 10.3 supplemented, P = 0.001). Most importantly, the SCC burden was reduced after Zn supplementation in both strains and genders of mice, most significantly in the wild-type males (P = 0.035). Although the mechanism(s) of action of Zn supplementation in skin tumor prevention is not known in detail, the Zn-supplemented tumors showed evidence of reduced DNA damage and some cohorts showed reduced inflammation scores. The results suggest that mild Zn supplementation should be tested for prevention of skin cancer in high-risk human cohorts

Systematic Approach to Installing a Computer Product

This study is cocerned with the approach to installing a computer product. In separate chapters, it describes procedures to install a hardware device and a software package. An extensive discussion about techniques for testing and debugging, which are two important procedures in a software package installation processes, is also included.Computer Scienc

Electronic Theory for Bilayer-Effects in High-T_c Superconductors

The normal and the superconducting state of two coupled CuO_2 layers in the High-T_c superconductors are investigated by using the bilayer Hubbard model, the FLEX approximation on the real frequency axis and the Eliashberg theory. We find that the planes are antiferromagnetically correlated which leads to a strongly enhanced shadow band formation. Furthermore, the inter-layer hopping is renormalized which causes a blocking of the quasi particle inter-plane transfer for low doping concentrations. Finally, the superconducting order parameter is found to have a d_{x^2-y^2} symmetry with significant additional inter-layer contributions.Comment: 5 pages, Revtex, 4 postscript figure

Pairing and Phase Coherence in High Temperature Superconductors

Mobile holes in an antiferromagnetic insulator form a slowly fluctuating array of quasi one-dimensional metallic stripes, which induce a spin gap or pseudogap in the intervening Mott-insulating regions. The mobile holes on an individual stripe acquire a spin gap via pair hopping between the stripe and its environment; i.e. via a magnetic analog of the usual superconducting proximity effect. This process is the analog of pairing in conventional superconductors. At non-vanishing stripe densities, Josephson coupling between stripes produces a dimensional crossover to a state with long-range superconducting phase coherence. In contrast to conventional superconductors, the superconducting state is characterised by a high density of (spin) pairs, but the phase stiffness, which is determined by the density and mobility of holes on the stripes, is very low.Comment: 4 pages. Proceedings of MMS-High Temperature Superconductivity, V (1997) To be published in Physica

Magnetic resonance at 41 meV and charge dynamics in YBa_2Cu_3O_6.95

We report an Eliashberg analysis of the electron dynamics in YBa_2Cu_3O_6.95. The magnetic resonance at 41 meV couples to charge carriers and defines the characteristic shape in energy of the scattering rate \tau^{-1}(T,\omega) which allows us to construct the charge-spin spectral density I^2\chi(\omega,T) at temperature T. The T dependence of the weight under the resonance peak in I^2\chi(\omega,T) agrees with experiment as does that of the London penetration depth and of the microwave conductivity. Als, at T=0 condensation energy, the fractional oscillator strength in the condensate, and the ratio of gap to critical temperature agree well with the data.Comment: 7 Pages, 3 Figures, accepted for publication in Europhysics Letter

The IPO initial returns-aftermarket risk question revisited: evidence from firms in Taiwan

The purpose of this study is to utilize the Three Stage Least Squares (3SLS) of the simultaneous equation estimation approach to revisit the possible cross relationship between IPO initial returns and aftermarket risk. A structural form equation system of IPO initial returns and aftermarket risk equations is estimated first to obtain the structural form coefficients. The analytically derived reduced form coefficients are then calculated to analyze the net effects of each exogenous variable on two endogenous variables. Major findings of this study are as follows. First, the signs of net effects of all exogenous variables on IPO initial returns and aftermarket risk are the same. In other words, any change in exogenous variables, IPO initial returns and IPO aftermarket risk will change in the same direction, i.e., the higher (lower) the IPO initial returns, the higher (lower) the IPO aftermarket risk. Second, the less the degree of corporate governance, the higher the IPO initial returns and aftermarket risk. Third, the higher the market risk or return before IPO, the higher the IPO initial returns and aftermarket risk

Effects of carvedilol on cardiac autonomic nerve activities during sinus rhythm and atrial fibrillation in ambulatory dogs

AIMS: We hypothesized that carvedilol can effectively suppress autonomic nerve activity (ANA) in ambulatory dogs during sinus rhythm and atrial fibrillation (AF), and that carvedilol withdrawal can lead to rebound elevation of ANA. Carvedilol is known to block pre-junctional β2-adrenoceptor responsible for norepinephrine release. METHODS AND RESULTS: We implanted radiotransmitters to record stellate ganglion nerve activity (SGNA), vagal nerve activity (VNA), and superior left ganglionated plexi nerve activity (SLGPNA) in 12 ambulatory dogs. Carvedilol (12.5 mg orally twice a day) was given for 7 days during sinus rhythm (n = 8). Four of the eight dogs and an additional four dogs were paced into persistent AF. Carvedilol reduced heart rate [from 103 b.p.m. (95% confidence interval (CI), 100-105) to 100 b.p.m. (95% CI, 98-102), P = 0.044], suppressed integrated nerve activities (Int-NAs, SGNA by 17%, VNA by 19%, and SLGPNA by 12%; all P < 0.05 vs. the baseline), and significantly reduced the incidence (from 8 ± 6 to 3 ± 3 episodes/day, P < 0.05) and total duration (from 68 ± 64 to 16 ± 21 s/day, P < 0.05) of paroxysmal atrial tachycardia (PAT). Following the development of persistent AF, carvedilol loading was associated with AF termination in three dogs. In the remaining five dogs, Int-NAs were not significantly suppressed by carvedilol, but SGNA significantly increased by 16% after carvedilol withdrawal (P < 0.001). CONCLUSION: Carvedilol suppresses ANA and PAT in ambulatory dogs during sinus rhythm