255 research outputs found
Parental Rights in Myspace: Reconceptualizing the State\u27s Parens Patriae Role in the Digital Age
Generally, parents have a great deal of leeway in their childrearing decisions, including choices in the content of their children\u27s internet use. But there is a harm about which many parents and state and federal governments are unaware: reputational harm. Children and teenagers\u27 current internet use puts them at risk of permanently harming their reputations, and there are no protective measures in place, whether educational or regulatory. They are posting personal information on the internet at an alarming rate mostly via social networking sites like MySpace.com and Facebook.com without an awareness of the present and long-term consequences, such as the ease of dissemination and the enduring nature of internet content. The risk that children\u27s present internet activity could irreparably harm their reputations in the future as they pursue higher education, professional careers, and even personal relationships, is sufficiently weighty that the government should step in as parens patriae to combat it and protect our children\u27s long-term freedom. To ensure our children and teenagers have the opportunity to develop their identities without the internet prematurely creating it for them, we must develop narrow regulations bolstered by education-based initiatives to protect the young from long-term consequences of their immature speech. While our current parental rights and First Amendment jurisprudence addresses most of the concerns that we have about children and teenager\u27s internet use, reputational harm requires special, more nuanced standards
Minimizing the Cost and Enhancing the Security for Cloud Hosting Service
Cloud computing is a new emerging technology which provides different kinds of services through internet and reduces maintenance cost as well as provides data reliability. Now a days many cloud service providers are providing services with different policies and prices. But it leads difficult to customers to choose cloud services with less price. That clients as a rule put their information into a single cloud and after that just trust to luckiness. Proposing new data hosting technique termed as CHARM which supports two strong functionalities.The first is selecting a few suitable clouds and a fitting excess system to store information with minimized financial expense and ensured accessibility.The second is setting off a move procedure to re-disperse information as indicated by the varieties of information access example and evaluating of clouds.In this project defining secret sharing algorithm to reduce the risk of data intrusion and the loss of service availability in the cloud and ensure data integrity. Finally proposed scheme not only saves the cost and also Maintains data and price adjustments
Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts
Complement Factor I deficiency: a potentially treatable cause of fulminant cerebral inflammation
Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland
Factor H autoantibodies can impair complement
regulation, resulting in atypical hemolytic uremic
syndrome, predominantly in childhood. There are no trials
investigating treatment, and clinical practice is only
informed by retrospective cohort analysis. Here we
examined 175 children presenting with atypical hemolytic
uremic syndrome in the United Kingdom and Ireland for
factor H autoantibodies that included 17 children with
titers above the international standard. Of the 17, seven
had a concomitant rare genetic variant in a gene encoding
a complement pathway component or regulator. Two
children received supportive treatment; both developed
established renal failure. Plasma exchange was associated
with a poor rate of renal recovery in seven of 11 treated. Six
patients treated with eculizumab recovered renal function.
Contrary to global practice, immunosuppressive therapy to
prevent relapse in plasma exchange–treated patients was
not adopted due to concerns over treatment-associated
complications. Without immunosuppression, the relapse
rate was high (five of seven). However, reintroduction of
treatment resulted in recovery of renal function. All
patients treated with eculizumab achieved sustained
remission. Five patients received renal transplants without
specific factor H autoantibody–targeted treatment with
recurrence in one who also had a functionally significant CFI mutation. Thus, our current practice is to initiate
eculizumab therapy for treatment of factor H
autoantibody–mediated atypical hemolytic uremic
syndrome rather than plasma exchange with or without
immunosuppression. Based on this retrospective analysis
we see no suggestion of inferior treatment, albeit the
strength of our conclusions is limited by the small sample siz
Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis
Background: Catalase is an important antioxidant enzyme that regulates the level of intracellular hydrogen peroxide and hydroxyl radicals. The effects of catalase deficiency on albuminuria and progressive glomerulosclerosis have not yet been fully elucidated. The adriamycin (ADR) nephropathy model is considered to be an experimental model of focal segmental glomerulosclerosis. A functional catalase deficiency was hypothesized to exacerbate albuminuria and the progression of glomerulosclerosis in this model.
Methods: ADR was intravenously administered to both homozygous acatalasemic mutant mice (C3H/AnLCs(b)Cs(b)) and control wild-type mice (C3H/AnLCs(a)Cs(a)). The functional and morphological alterations of the kidneys, including albuminuria, renal function, podocytic, glomerular and tubulointerstitial injuries, and the activities of catalase were then compared between the two groups up to 8 weeks after disease induction. Moreover, the presence of a mutation of the toll-like receptor 4 (tlr4) gene, which was previously reported in the C3H/HeJ strain, was investigated in both groups.
Results: The ADR-treated mice developed significant albuminuria and glomerulosclerosis, and the degree of these conditions in the ADR-treated acatalasemic mice was higher than that in the wild-type mice. ADR induced progressive renal fibrosis, renal atrophy and lipid peroxide accumulation only in the acatalasemic mice. In addition, the level of catalase activity was significantly lower in the kidneys of the acatalasemic mice than in the wild-type mice during the experimental period. The catalase activity increased after ADR injection in wild-type mice, but the acatalasemic mice did not have the ability to increase their catalase activity under oxidative stress. The C3H/AnL strain was found to be negative for the tlr4 gene mutation.
Conclusions: These data indicate that catalase deficiency plays an important role in the progression of renal injury in the ADR nephropathy model
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