26 research outputs found
Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program
Summary Microglia, the brain-resident immune cells, are critically involved in many physiological and pathological brain processes, including neurodegeneration. Here we characterize microglia morphology and transcriptional programs across ten species spanning more than 450 million years of evolution. We find that microglia express a conserved core gene program of orthologous genes from rodents to humans, including ligands and receptors associated with interactions between glia and neurons. In most species, microglia show a single dominant transcriptional state, whereas human microglia display significant heterogeneity. In addition, we observed notable differences in several gene modules of rodents compared with primate microglia, including complement, phagocytic, and susceptibility genes to neurodegeneration, such as Alzheimerâs and Parkinsonâs disease. Our study provides an essential resource of conserved and divergent microglia pathways across evolution, with important implications for future development of microglia-based therapies in humans
Supplementary Figure S7 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
The metastatic invasive margin is populated by suppressive TREM2 macrophages.</p
Supplementary Figure S3 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
The pre-metastatic lung microenvironment is characterized by activation of monocytes and neutrophils.</p
Supplementary Figure S5 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
Cell-cell interactions among immune cells vary within metastatic lung tissues.</p
Supplementary Figure S3 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
The pre-metastatic lung microenvironment is characterized by activation of monocytes and neutrophils.</p
Supplementary Figure S6 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
The metastatic core and invasive margin are populated by distinct macrophage subpopulations.</p
Supplementary Table S1 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
Log footprint of metacells</p
Supplementary Figure S7 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
The metastatic invasive margin is populated by suppressive TREM2 macrophages.</p
Supplementary Figure S5 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
Cell-cell interactions among immune cells vary within metastatic lung tissues.</p
Supplementary Table S2 from Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary
Mouse cellular makeup</p