Site-selectivite Synthesis and Tautomerism of Arylazo Derivatives of Pyrazolo[3,4-d]pyrimido-[1,6-b][1,2,4]triazine

A simple synthetic strategy is described for synthesis of the hitherto unreported 5-arylazo-1,3-diphenyl-6-substituted-1H-pyrazolo[3,4-d]pyrimido[1,6-b][1,2,4]triazines 5a-n. The spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form 5A. The site-selectivity and mechanism of the studied reactions are discussed

Regioselective synthesis of some functionalized 3,4’-bis-(pyrazolyl)ketones and chemoselectivity in their reaction with hydrazine hydrate

A new enamino ester, (E)-ethyl 3-(dipropylamino)acrylate, was prepared and used for synthesis of various pyrazole derivatives, 4a-k and 5a-d. Other new enaminone, (E)-ethyl 3-(3-(dimethylamino)acryloyl)-1-(4-nitrophenyl)-1H-pyrazole-4-carboxylate (8), was also prepared from compound 4a and utilized as precursor for synthesis of different functionalized 3,4'-bis-pyrazolyl ketones 9a-c, 10a-c. The site selectivity in hydrazinolysis of the latter was studied. The structures of the products namely pyrazolo[3,4-d]pyridazine derivatives 11(13) were confirmed by spectral and elemental analyses and by alternate unambiguous synthesis

En tverrsnittsstudie av hvilke faktorer som påvirker selvopplevd helse blant ikke-vestlige mødre i Akershus og Østfold

Master i helse og empowermentBakgrunn: Andelen personer med innvandrerbakgrunn har økt i Norge de siste tiårene. Flere ulike studier gjennomført blant ikke-vestlige kvinner, konkluderte med at helsetilstanden til denne gruppen avviker fra helsetilstanden til befolkningen generelt. Dette gjelder både faktisk helse og selvopplevd helse. Hensikt: Hensikten med studien var å undersøke mulig samvariasjon mellom selvopplevd helse og faktorene følelse av sammenheng (Sense of coherence, SOC), språkferdigheter, ernæringsatferd og fysisk aktivitet i en gruppe kvinner med ikke-vestlige bakgrunn. Metode: Tverrsnittsstudie av 101 kvinner med ikke – vestlige bakgrunn i aldersgruppen 18 – 45 år, bosatt i Akershus og Østfold. Deltakerne besvarte et spørreskjema som dekket sosiodemografiske og helserelaterte variabler i tillegg til selvopplevd helse, SOC, språkferdigheter, ernæringsatferd og fysisk aktivitet. Samvariasjon ble testet med korrelasjon (Pearsons R) og multippel lineær regresjonsanalyse. Resultater: Totalt 42 prosent av deltakerne anga sin helse som god/svært god, mens kun 6 prosent anga sin helse som dårlig. Bivariat korrelasjonsanalyse viste en svak til moderat sammenheng mellom selvopplevd helse og SOC (R² = 0,41), ernæringsatferd (R² = 0,26), fysisk aktivitet (R² = 0,30), språkferdigheter(R² = 0,33), antall personer i husstanden som er under 18 år (R² = ˗ 0,22) og KMI (R² = ˗ 0,15). Multippel lineær regresjonsanalysen viste at variasjonen i selvopplevd helse kun samvarierer signifikant med SOC (Beta = 0,19, p = 0,045) og fysisk aktivitet (Beta = 0,36, p < 0,001). Konklusjon: Denne studien viser at variasjon i SOC og fysisk aktivitet kan forklare variasjonen av selvopplevd helse hos utvalgte kvinner med ikke-vestlige bakgrunn. Det er behov for å gjøre flere og større studier som eventuelt kan bekrefte eller avkrefte dissefunnene.Background: The proportion of people with immigrant backgrounds has increased in Norway in recent decades. Several studies conducted among non-Western women, concluded that the health status of this group differs from the state of health of the general population. This applies to both actual health and self-perceived health. Purpose: The purpose of this study was to investigate whether there is correlation between self-perceived health and the factors sense of coherence (SOC), language skills, nutrition and physical activity behaviors in a group of women with non-Western background. Method: Cross-sectional study of 101 women with non - Western backgrounds aged 18-45 years residing in Akershus and Østfold. The participants answered a questionnaire that covered socio-demographic and health-related variables in addition to self-perceived health, SOC, language skills, nutrition behavior and physical activity. Correlation was tested with correlation (Pearson's R) and multiple linear regression analysis. Results: Total 42 percent of participants appraised their health as good / very good, while only 6 percent appraised their health as poor. Bivariate correlation analysis showed a weak to moderate correlation between self-perceived health and SOC (R ² = 0.41), nutrition behavior (R ² = 0.26), physical activity (R ² = 0.30), language skills (R ² = 0.33), number of people in your household who are under 18 (R ² = ˗ 0.22) and BMI (R ² = ˗ 0.15). Multiple linear regression analysis showed that the variation in perceived health only correlated significantly with SOC (Beta = 0.36, p <0.001) and physical activity (Beta = 0.19, p = 0.045). Conclusion: This study shows that variation in the SOC and physical activity can explain the variation of self-perceived health in selected women with non-Western backgrounds. Additional studies are needed to confirm or disprove these result

Synthesis of novel 3,4-dihydroquinoxalin-2(1H)-one derivatives

New derivatives of 3,4-dihydroquinoxaline-2(1H)-one were synthesized and characterized. Representative examples were evaluated for their antimicrobial and antifungal activities using Tetracycline and Nystatin as reference compound. One of the tested compounds 10a was found to exhibit slight activity against Staphylococcus aureus. Compounds 10b, 11b and 14b showed slight activity against Escherichia coli. Moreover, nineteen compounds were screened for their inhibition effect on CDK5, CK1, and GSK-3β. None of the tested compounds showed an inhibition activity below 10 µM concentration

Carbenic nitrile imines: Properties and reactivity

Structures and properties of nitrile imines were investigated computationally at B3LYP and CCSD(T) levels. Whereas NBO analysis at the B3LYP DFT level invariably predicts a propargylic electronic structure, CCSD(T) calculations permit a clear distinction between propargylic, allenic, and carbenic structures. Nitrile imines with strong IR absorptions above ca. 2150 cm-1 have propargylic structures with a CN triple bond (RCNNSiMe 3 and R2BCNNBR2), and those with IR absorptions below ca. 2150 cm-1 are allenic (HCNNH, PhCNNH, and HCNNPh). Nitrile imines lacking significant cumulenic IR absorptions at 1900-2200 cm -1 are carbenic (R-(C:)-N=N-R′). Electronegative but lone pair-donating groups NR2, OR, and F stabilize the carbenic form of nitrile imines in the same way they stabilize "normal" singlet carbenes, including N-heterocyclic carbenes. NBO analyses at the CCSD(T) level confirm the classification into propargylic, allenic, and carbenic reactivity types. Carbenic nitrile imines are predicted to form azoketenes 21 with CO, to form [2+2] and [2+4] cycloadducts and borane adducts, and to cyclize to 1H-diazirenes of the type 24 in mildly exothermic reactions with activation energies in the range 29-38 kcal/mol. Such reactions will be readily accessible photochemically and thermally, e.g., under the conditions of matrix photolysis and flash vacuum thermolysis

Ethyl (Z)-2-chloro-2-(2-phenyl­hydrazin-1-yl­idene)acetate

The title compound, C10H11ClN2O2, features an almost planar Car—N(H)—N=C(Cl) unit [torsion angle = 0.8 (1)° whose phenyl substituent is almost coplanar with it [dihedral angle = 2.8 (2)°]; this unit is slightly twisted with respect to the carboxyl –CO2 fragment [dihedral angle = 10.3 (2)°]. In the crystal, the amino group acts as a hydrogen-bond donor to the carbonyl O atom of an adjacent mol­ecule; the hydrogen bond generates a helical chain that runs along the b axis of the monoclinic unit cell

Ethyl 2-chloro-[2-(4-chloro­phen­yl)hydrazin-1-yl­idene]acetate

The title compound, C10H10Cl2N2O2, features a planar Car—N(H)—N=C(Cl) unit [torsion angle = 5.5 (4)°] whose benzene substituent is coplanar with it [dihedral angle = 4.7 (4)°]; this unit is slightly twisted with respect to the carboxyl –CO2 fragment [dihedral angle = 2.2 (52)°]. The amino group acts as a hydrogen-bond donor to the carbonyl O atom of an adjacent mol­ecule; the hydrogen bond generates a helical polymer that runs along the b axis of the monoclinic unit cell

4-Bromo­benzoic acid–6-(4-bromo­phen­yl)-3-methyl-1,2,4-triazolo[3,4-b][1,3,4]thia­diazole (1/1)

In the title 1:1 co-crystal, C10H7BrN4S·C7H5BrO2, the triazolothia­diazole system is approximately planar [with a maximum deviation of 0.030 (4) Å] and forms a dihedral angle of 8.6 (1)° with the bromo­phenyl ring. In the carb­oxy­lic acid mol­ecule, the carboxyl group is rotated by 6.4 (3)° out of the benzene ring plane. The crystal structure features O—H⋯N and C—H⋯O hydrogen bonds, π–π stacking inter­actions [centroid–centroid distances = 3.713 (2), 3.670 (2) and 3.859 (3) Å] and short S⋯N [2.883 (4) Å] contacts

A convenient synthesis of 5-amino-4-(2-benzothiazolyl)pyrazoles

1175-117

3-[1-(4-Isobutyl­phen­yl)eth­yl]-6-(4-methyl­phen­yl)-1,2,4-triazolo[3,4-b][1,3,4]thia­diazole

In the title compound, C22H24N4S, the methylphenyl and isobutylphenyl rings are inclined at an angle of 79.98 (1)° and they form dihedral angles of 4.59 (1) and 75.47 (1)°, respectively, with the triazolothia­diazole unit. An intra­molecular C—H⋯S hydrogen bond generates an S(5) ring motif. The crystal structure is stabilized by inter­molecular C—H⋯N hydrogen bonds and weak C—H⋯π and π–π inter­actions [centroid–centroid distances between the thia­diazole ring and a symmetry-related phenyl ring and between the triazole ring and the phenyl ring range from 3.5680 (8) to 3.7313 (8) Å]