538 research outputs found

    Notas de Campo na Pesquisa Etnográfica

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    The Untold Story of Welfare Fraud

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    The experiences of women who have been charged with welfare fraud in the years following the passage of the 1996 Personal Responsibility and Work Opportunity Reconciliation Act cast a shadow over the claim that welfare reform has been an unequivocal success. This article addresses this under-explored issue by considering the face of welfare fraud in San Diego, California after the change to federal welfare law. After a brief discussion of the socio-historical context of welfare fraud prosecution and a summary of the scholarly findings related to welfare fraud post-PRWORA, the aiticle details a new poverty knowledge about welfare fraud drawn from the experiences of women. This is followed by a discussion of how this knowledge has been used to help inspire the creation of a welfare fraud diversion program that serves as an alternative to felony prosecution for first-time, low-level welfare fraud defendants in San Diego County

    Regular Orbits and Periodic Loops in Multiply-Barred Galactic Potentials

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    We show that non-chaotic multiply-periodic particle orbits can exist in a galaxy-like potential where a small fast-tumbling nuclear bar is nested inside a main bar which has a slower pattern speed. We introduce the concept of a loop: a one-dimensional curve such that particles distributed along it at some initial instant return to the same curve (as viewed in the rotating frame of one of the bars) after the bars return to the same relative position. Just as particles following regular orbits in a simply-barred potential are trapped around closed periodic orbits, so regular orbits in a doubly-barred potential oscillate about stable loops. We find both loops which remain aligned with the inner bar and loops aligned with the outer bar: particles trapped around these loops could form the building blocks for a long-lived, self-consistent, doubly-barred galaxy. In a realistic doubly-barred galaxy potential, we demonstrate the existence of stable loops which support the structure of the inner bar. We use the epicyclic approximation to preview the pattern of gas flow in a doubly-barred potential.Comment: 6 pages, 1 figure, submitted to ApJ Letter

    Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction

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    BACKGROUND: Prolonged QRS duration is associated with increased mortality among heart failure patients, but race or sex differences in QRS duration and associated effect on outcomes are unknown. METHODS AND RESULTS: We investigated QRS duration and morphology among 2463 black and white patients with heart failure and left ventricular ejection fraction ≤35% who underwent coronary angiography and 12-lead electrocardiography at Duke University Hospital from 1995 through 2011. We used multivariable Cox regression models to assess the relationship between QRS duration and all-cause mortality and investigate race-QRS and sex-QRS duration interaction. Median QRS duration was 105 ms (interquartile range [IQR], 92-132) with variation by race and sex (P<0.001). QRS duration was longest in white men (111 ms; IQR, 98-139) followed by white women (108 ms; IQR, 92-140), black men (100 ms; IQR, 91-120), and black women (94 ms; IQR, 86-118). Left bundle branch block was more common in women than men (24% vs 14%) and in white (21%) versus black individuals (12%). In black patients, there was a 16% increase in risk of mortality for every 10 ms increase in QRS duration up to 112 ms (hazard ratio, 1.16; 95% CI, 1.07, 1.25) that was not present among white patients (interaction, P=0.06). CONCLUSIONS: Black individuals with heart failure had a shorter QRS duration and more often had non-left bundle branch block morphology than white patients. Women had left bundle branch block more commonly than men. Among black patients, modest QRS prolongation was associated with increased mortality

    An Imaging Survey of Early-Type Barred Galaxies

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    This paper presents the results of a high-resolution imaging survey, using both ground-based and Hubble Space Telescope images, of a complete sample of nearby barred S0--Sa galaxies in the field, with a particular emphasis on identifying and measuring central structures within the bars: secondary bars, inner disks, nuclear rings and spirals, and off-plane dust. A discussion of the frequency and statistical properties of the various types of inner structures has already been published. Here, we present the data for the individual galaxies and measurements of their bars and inner structures. We set out the methods we use to find and measure these structures, and how we discriminate between them. In particular, we discuss some of the deficiencies of ellipse fitting of the isophotes, which by itself cannot always distinguish between bars, rings, spirals, and dust, and which can produce erroneous measurements of bar sizes and orientations.Comment: LaTeX, 66 pages (including 42 figures, 36 in color). To appear in The Astrophysical Journal Supplement. Full-resolution and text-only versions available at http://www.iac.es/galeria/erwin/research

    Increased Expression in Dorsolateral Prefrontal Cortex of CAPON in Schizophrenia and Bipolar Disorder

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    BACKGROUND: We have previously reported linkage of markers on chromosome 1q22 to schizophrenia, a finding supported by several independent studies. Within this linkage region, we have identified significant linkage disequilibrium between schizophrenia and markers within the gene for carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON). Prior sequencing of the ten exons of CAPON failed to reveal a coding mutation associated with illness. METHODS AND FINDINGS: We screened a human fetal brain cDNA library and identified a new isoform of CAPON that consists of the terminal two exons of the gene, and verified the expression of the predicted corresponding protein in human dorsolateral prefrontal cortex (DLPFC). We examined the expression levels of both the ten-exon CAPON transcript and this new isoform in postmortem brain samples from the Stanley Array Collection. Quantitative real-time PCR analysis of RNA from the DLPFC in 105 individuals (35 with schizophrenia, 35 with bipolar disorder, and 35 psychiatrically normal controls) revealed significantly (p < 0.005) increased expression of the new isoform in both schizophrenia and bipolar disorder. Furthermore, this increased expression was significantly associated (p < 0.05) with genotype at three single-nucleotide polymorphisms previously identified as being in linkage disequilibrium with schizophrenia. CONCLUSION: Based on the known interactions between CAPON, neuronal nitric oxide synthase (nNOS), and proteins associated with the N-methyl-D-aspartate receptor (NMDAR) complex, overexpression of either CAPON isoform would be expected to disrupt the association between nNOS and the NMDAR, leading to changes consistent with the NMDAR hypofunctioning hypothesis of schizophrenia. This study adds support to a role of CAPON in schizophrenia, produces new evidence implicating this gene in the etiology of bipolar disorder, and suggests a possible mechanism of action of CAPON in psychiatric illness
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