Assessment of the efficiency of Russian response to the implementation of US missile defence deployment concept in Europe

This article is dedicated to the problems of deployment of the US anti-missile defence system in Eastern Europe. The European system of US missile defence is just one of the components of global US missile defence. This work aims to analyze possible Russia’s responses within military and political spheres. The measures proposed are divided into three subgroups: soft, medium and hard depending on the implementation of the adopted missile defence concept by the USA. This research employs the structure-system method and the method of actualization. The authors outline both positive and negative consequences of such actions for the Russian Federation, the USA, eastern European countries and the neighbouring countries, including the Baltic Sea states. The practical significance of this study consists in the proposed and justified responses of the Russian Federation that may serve as a basis for the scenarios of development of international situation and help to forecast the level of tension in Russia-US relations

Diversity of <i>mariner</i>-like elements in Orthoptera

Mariner-like elements (MLEs) are among the most widespread DNA transposable elements in eukaryotes. Insects were the first organisms in which MLEs were identified, however the diversity of MLEs in the insect order Orthoptera has not yet been addressed. In the present study, we explore the diversity of MLEs elements in 16 species of Orthoptera belonging to three infraorders, Acridoidea (Caelifera), Grylloidea (Ensifera), and Tettigoniidea (Ensifera) by combining data mined from computational analysis of sequenced degenerative PCR MLE amplicons and available Orthoptera genomic scaffolds. In total, 75 MLE lineages (Ortmar) were identified in all the studied genomes. Automatic phylogeny-based classification suggested that the current known variability of MLEs can be assigned to seven statistically well-supported phylogenetic clusters (I–VII), and the identified Orthoptera lineages were distributed among all of them. The majority of the lineages (36 out of 75) belong to cluster I; 20 belong to cluster VI; and seven, six, four, one and one lineages belong to clusters II, IV, VII, III, and V, respectively. Two of the clusters (II and IV) were composed of a single Orthoptera MLE lineage each (Ortmar37 and Ortmar45, respectively) which were distributed in the vast majority of the studied Orthoptera genomes. Finally, for 16 Orthoptera MLE lineages, horizontal transfer from the distantly related taxa belonging to other insect orders may have occurred. We believe that our study can serve as a basis for future researches on the diversity, distribution, and evolution of MLEs in species of other taxa that are still lacking the sequenced genomes

ЭФФЕКТИВНОСТЬ СТАЦИОНАРНОГО ЭТАПА ЛЕЧЕНИЯ БОЛЬНЫХ ТУБЕРКУЛЕЗОМ С ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮ МИКОБАКТЕРИЙ

The composition and effectiveness of the treatment of patients 159 drug-resistant TB of Mycobacterium tuberculosis. Dominated by common processes (87%), massive bacterioexcretion (74.2%) and multidrug-resistant TB. Full clinical effect achieved in 54.8% (n = 68), including 28.8% (37) by surgical methods. Изучен состав и эффективность лечения 159 больных туберкулезом с лекарственной устойчиво-стью (ЛУ) микобактерий туберкулеза, преимущественно множественной. Преобладали распро-страненные процессы (в 87%) с массивным бактериовыделением (74,2%) и с ЛУ ко всем препара-там основного ряда. Полный клинический эффект достигнут в 54,8% (у 68 больных), в том числе в 28,8% (у 37) хирургическими методами

Міжнародний досвід регулювання підприємницької діяльності

The article considers the peculiarities of the state support of entrepreneurial activity in different countries, generalizes the experience of a small and medium-sized business participation in the development of high-tech sector of economy.У статті розглянуто особливості державної підтримки підприємницької діяльності в різних країнах, узагальнено досвід участі малого та середнього бізнесу у розвитку високотехнологічного сектору економіки

THE CURRENT STATE OF DATA TRANSMISSION CHANNELS FROM PUSHCHINO TO MOSCOW AND PERSPECTIVES

Since the work of a unique space radio telescope in the international VLBI project ”Radioastron” extended to 2017 the transmission and storage of large volumes of scientific and telemetry data obtained during the experiments is still remains actual. This project is carried out by theAstroSpaceCenter of Lebedev Physical Institute inMoscow,Russia. It requires us to maintain in operating state the high-speed link to merge into a single LAN buffer data center in Puschino and scientific information center inMoscow. Still relevant the chanal equipment monitoring system, and storage systems, as well as the timely replacement of hardware and software upgrades, backups, and documentation of the network infrastructure.

ACUTE CEREBROVASCULAR EVENTS IN PATIENTS WITH ARTERIAL HYPERTENSION: MOLECULAR GENETIC ASPECTS

Aim. To study association between stroke and gene polymorphism of angeotensin converting enzyme (ACE), angeotensin II type 1 receptor (ATR1), apolipoprotein СIII (APO CIII), apoproteine Е (APO E), methylentetrahydrofolate reductase (MTHFR), fibrinogen (Fb), endothelial NO-synthase (NOS3) in arterial hypertension (HT).Material and methods. Molecular genetic analysis by polymerase chain reaction was done in 41 patients with HT, who experienced first episode of acute disturbances of cerebral blood circulation (ADCBC).Results. Stroke rate in patients with HT is associated with A1166C of ATR1 gene polymorphism, G-455A of Fb gene polymorphism and C677T of MTHFR gene polymorphism. The high risk markers are C-allele of ATR1 gene, -455А allele and AA genotype of Fb gene, 677T allele of MTHFR. The A-allele and genotype AA of ATR1 gene, G-445 allele of Fb gene, С677-allele and CC genotype of MTHFR gene play protective role against ADCBC in HT.Conclusion. It is established an association between gene polymorphism of some molecules and ADCBC in HT

RESULTS OF TREATMENT OF OPEN FRACTURES IN PATIENTS WITH POLYTRAUMA IN A REGIONAL TRAUMA SYSTEM

Aim. To analyze options for treatment tactics for open fractures of bones, implemented in a regional trauma system in theKrasnodar Territory.Materials and methods. Retrospective analysis includes the results of treatment of 82 patients with polytrauma and severe open fractures of the shin bones aged from 18 to 60 years, of whom 23 in unstable or critical condition, hospitalized in 2016-2017 in the Scientific Research Institution – S.V. Ochapovsky Regional Clinical Hospital № 1.Results. Treatment tactics for patients with severe polytrauma and open fractures type IIIA and B according to the classification of Gustilo-Andersen adopted in trauma center of level I, reduces the total number of infectious complications to 9,09% for fractures of type III A and 53,84% of IIIB fractures compared to option treatment strategies adopted in trauma centres II, III where the level of infection reaches 58,06% fractures type III A and 93,75% of IIIB fractures. The typical mistakes made in primary surgical treatment in patients with polytrauma and severe open fractures were revealed: incomplete revision of the wound with leaving foreign bodies, non-viable soft tissues, unstable fixation of the fracture with the help of a skeletal traction system, incomplete external fixation of the fracture with a device or plaster bandage, suturing of the wound with relaxing skin incisions during soft tissue swelling, absence of drains or passive drainage of the open fracture.Conclusion. The usage of primary surgical treatment in a reduced volume, with the application of VAC-dressings, in patients with polytrauma and severe open fractures of the limb bones can reduce the overall incidence of infectious complications