Assessment of the efficiency of Russian response to the implementation of US missile defence deployment concept in Europe

This article is dedicated to the problems of deployment of the US anti-missile defence system in Eastern Europe. The European system of US missile defence is just one of the components of global US missile defence. This work aims to analyze possible Russia’s responses within military and political spheres. The measures proposed are divided into three subgroups: soft, medium and hard depending on the implementation of the adopted missile defence concept by the USA. This research employs the structure-system method and the method of actualization. The authors outline both positive and negative consequences of such actions for the Russian Federation, the USA, eastern European countries and the neighbouring countries, including the Baltic Sea states. The practical significance of this study consists in the proposed and justified responses of the Russian Federation that may serve as a basis for the scenarios of development of international situation and help to forecast the level of tension in Russia-US relations

Diversity of <i>mariner</i>-like elements in Orthoptera

Mariner-like elements (MLEs) are among the most widespread DNA transposable elements in eukaryotes. Insects were the first organisms in which MLEs were identified, however the diversity of MLEs in the insect order Orthoptera has not yet been addressed. In the present study, we explore the diversity of MLEs elements in 16 species of Orthoptera belonging to three infraorders, Acridoidea (Caelifera), Grylloidea (Ensifera), and Tettigoniidea (Ensifera) by combining data mined from computational analysis of sequenced degenerative PCR MLE amplicons and available Orthoptera genomic scaffolds. In total, 75 MLE lineages (Ortmar) were identified in all the studied genomes. Automatic phylogeny-based classification suggested that the current known variability of MLEs can be assigned to seven statistically well-supported phylogenetic clusters (I–VII), and the identified Orthoptera lineages were distributed among all of them. The majority of the lineages (36 out of 75) belong to cluster I; 20 belong to cluster VI; and seven, six, four, one and one lineages belong to clusters II, IV, VII, III, and V, respectively. Two of the clusters (II and IV) were composed of a single Orthoptera MLE lineage each (Ortmar37 and Ortmar45, respectively) which were distributed in the vast majority of the studied Orthoptera genomes. Finally, for 16 Orthoptera MLE lineages, horizontal transfer from the distantly related taxa belonging to other insect orders may have occurred. We believe that our study can serve as a basis for future researches on the diversity, distribution, and evolution of MLEs in species of other taxa that are still lacking the sequenced genomes

ЭФФЕКТИВНОСТЬ СТАЦИОНАРНОГО ЭТАПА ЛЕЧЕНИЯ БОЛЬНЫХ ТУБЕРКУЛЕЗОМ С ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮ МИКОБАКТЕРИЙ

The composition and effectiveness of the treatment of patients 159 drug-resistant TB of Mycobacterium tuberculosis. Dominated by common processes (87%), massive bacterioexcretion (74.2%) and multidrug-resistant TB. Full clinical effect achieved in 54.8% (n = 68), including 28.8% (37) by surgical methods. Изучен состав и эффективность лечения 159 больных туберкулезом с лекарственной устойчиво-стью (ЛУ) микобактерий туберкулеза, преимущественно множественной. Преобладали распро-страненные процессы (в 87%) с массивным бактериовыделением (74,2%) и с ЛУ ко всем препара-там основного ряда. Полный клинический эффект достигнут в 54,8% (у 68 больных), в том числе в 28,8% (у 37) хирургическими методами

Lipid profile of patients with arterial hypertension who underwent COVID-19: possibilities of drug therapy/ LEADER

Aim. To study the dynamics of the lipid profile of hypertensive patients with dyslipidemia who underwent COVID-19.Material and methods. Hypertensive patients with dyslipidemia who underwent COVID-19 [n=126; 58 men and 68 women; median age 60 (56.0; 65.5) years] examined. Patients were included into two groups: group 1 (n=64) received a single pill combination of lisinopril + amlodipine + rosuvastatin; 2 groups (n=62) continued the previous drug treatment. Clinical, demographic, office blood pressure (BP), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol, triglycerides, C-reactive protein (CRP) levels were assessed in all patients in 3 visits within 24 weeks.Results. The groups did not differ in prior antihypertensive therapy (except for more frequent use of angiotensin II receptor blockers in group 2, p&lt;0.05), lipid profile and blood pressure parameters at study entry. A decrease in systolic (by 9.5%) and diastolic blood pressure (by 12.1%) after 24 weeks was found in group 1 compared with 4.29% and 5.56%, respectively, in group 2 (p&lt;0.05). A decrease in the level of total cholesterol by 14.5% and LDL-c by 31.4% after 24 weeks was found in group 1 compared with 11.2% and 9.7%, respectively, in group 2 (p&lt;0.05). The level of CRP during the observation period decreased by 53.7% in group 1 versus 43.4% in patients of group 2 (p&lt;0.05).Conclusion. The single pill combination of lisinopril/amlodipine/rosuvastatin in hypertensive patients with dyslipidemia who underwent COVID-19 led to an improvement in lipid profile and blood pressure control

Asset management of transportation companies: Analysis and methods

The article deals with gaining some ideas and skills that an investor might use to choose the best opportunities in the market from among the thousands of options concentrated in the transport industry. The authors are also trying to build up a standard set of tools that make up the core of every stock analyst’s tool box. From the practical perspective, the ideas and techniques in the discussion part will be useful for analysing just every possible investment. A special focus in the article has been made on the transportation companies struggling with the consequences of the corona-crisis of 2020

ACUTE CEREBROVASCULAR EVENTS IN PATIENTS WITH ARTERIAL HYPERTENSION: MOLECULAR GENETIC ASPECTS

Aim. To study association between stroke and gene polymorphism of angeotensin converting enzyme (ACE), angeotensin II type 1 receptor (ATR1), apolipoprotein СIII (APO CIII), apoproteine Е (APO E), methylentetrahydrofolate reductase (MTHFR), fibrinogen (Fb), endothelial NO-synthase (NOS3) in arterial hypertension (HT).Material and methods. Molecular genetic analysis by polymerase chain reaction was done in 41 patients with HT, who experienced first episode of acute disturbances of cerebral blood circulation (ADCBC).Results. Stroke rate in patients with HT is associated with A1166C of ATR1 gene polymorphism, G-455A of Fb gene polymorphism and C677T of MTHFR gene polymorphism. The high risk markers are C-allele of ATR1 gene, -455А allele and AA genotype of Fb gene, 677T allele of MTHFR. The A-allele and genotype AA of ATR1 gene, G-445 allele of Fb gene, С677-allele and CC genotype of MTHFR gene play protective role against ADCBC in HT.Conclusion. It is established an association between gene polymorphism of some molecules and ADCBC in HT

Personality ecological consciousness: Values ethical vector of nature safety sustainable development

The relevance of the study is due to the current trends of the global environmental crisis. The ability of nature to self-purification in a man-made civilization is almost exhausted, and advances in science, technology, culture can no longer fundamentally affect the overcoming of the entrenched crisis. In the current difficult conditions, the importance of understanding that the solving the global environmental problem of human survival must be based on ethical values of equal interaction of nature, man and society. As one of the effective conditions to overcome the negative impact of human activity, the values’ ethical vector of nature safety sustainable development is substantiated. In this regard, on the basis of the study results the typology of the structure and content of environmental consciousness is identified and experimentally proved, determined by the ethical values of environmental safety sustainable development; the model of ethical values of environmental safety sustainable development is justified, acting as a priority for the transformation of environmental consciousness. The materials of the article have practical application and can be useful for the development and implementation of methods for environmental consciousness of different categories of the population formation, as well as in making management decisions that regulate environmental activities. © Foundation Environmental Protection & Research-FEPR

DATA PROCESSING CENTER FOR RADIOASTRON PROJECT HARDWARE OPTIMIZATION

The RadioAstron is an international space VLBI project led by the Astro Space Center of Lebedev Physical Institute inMoscow,Russia. The payload - Space Radio Telescope, is based on spacecraft Spektr-R, that have been designed by the Lavochkin Association. The Spektr-R space craft was successfully launched 18 th July 2011.In this article we want to summarize Radioastron data processing center work during 2 last years. Tasks facing of the scientific data processing center are organization of service information exchange, collection of scientific ob­servations, storage of scientific observations, processing of scientific observation data Radioastron project

HEART FAILURE, DIABETES, BETA-BLOCKERS AND RISK OF HYPOGLYCEMIA

Aim. To evaluate an influence of carvedilol on risk of hypoglycemia in patients with diabetes type 2 (D2) and chronic heart failure (CHF) treated with angiotensin converting enzyme (ACE) inhibitors.Material and methods. 13 patients (10 men, 3 women; aged 59,8±6,7 y.o.) with D2 and CHF caused by ischemic heart disease were included in the study. Before inclusion all patients were treated with ACE inhibitors and various beta-blockers (atenolol, metoprolol, bisoprolol). These beta-blockers were changed for carvedilol. Heart ultrasonography, blood pressure control, glycemia monitoring, HbA1c level determination were performed before, during and after carvedilol therapy.Results. Carvedilol reduces frequency and duration of hypoglycaemia episodes. There were not episodes of severe hypoglycaemia during carvedilol therapy.Conclusion. Carvedilol reduces risk of hypoglycemia when it is used in combination with ACE inhiditors in diabetic patients with CHF