Development of a polysilicon process based on chemical vapor deposition, phase 1

The development of a dichlorosilane-based reductive chemical vapor deposition process for the production of polycrystalline silicon is discussed. Experimental data indicate that the ease of ignition and explosion severity of dichlorosilane (DCS)/air mixtures is substantially attenuated if the DCS is diluted with hydrogen. Redesign of the process development unit to accommodate safety related information is described. Several different sources of trichlorosilane were used to generate a mixture of redistributed chlorosilanes via Dowex ion exchange resin. The unseparated mixtures were then fed to an experimental reactor in which silicon was deposited and the deposited silicon analyzed for electrically active impurities. At least one trichlorosilane source provided material of requisite purity. Silicon grown in the experimental reactor was converted to single crystal material and solar cells fabricated and tested

Genomic variations associated with attenuation in Mycobacterium avium subsp paratuberculosis vaccine strains

BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) whole cell vaccines have been widely used tools in the control of Johne's disease in animals despite being unable to provide complete protection. Current vaccine strains derive from stocks created many decades ago; however their genotypes, underlying mechanisms and relative degree of their attenuation are largely unknown. RESULTS: Using mouse virulence studies we confirm that MAP vaccine strains 316 F, II and 2e have diverse but clearly attenuated survival and persistence characteristics compared with wild type strains. Using a pan genomic microarray we characterise the genomic variations in a panel of vaccine strains sourced from stocks spanning over 40 years of maintenance. We describe multiple genomic variations specific for individual vaccine stocks in both deletion (26-32 Kbp) and tandem duplicated (11-40 Kbp) large variable genomic islands and insertion sequence copy numbers. We show individual differences suitable for diagnostic differentiation between vaccine and wild type genotypes and provide evidence for functionality of some of the deleted MAP-specific genes and their possible relation to attenuation. CONCLUSIONS: This study shows how culture environments have influenced MAP genome diversity resulting in large tandem genomic duplications, deletions and transposable element activity. In combination with classical selective systematic subculture this has led to fixation of specific MAP genomic alterations in some vaccine strain lineages which link the resulting attenuated phenotypes with deficiencies in high reactive oxygen species handling

The role of rotational mobility and power on throwing velocity

Abstract: Talukdar, K, Cronin, J, Zois, J, and Sharp, AP. The role of rotational mobility and power on throwing velocity. J Strength Cond Res 29(4): 905–911, 2015—Sound rotational power and mobility are an integral component in functional performances, such as throwing and striking. The purpose of this study was to examine the role of rotational power and mobility on cricket ball–throwing velocity. Eleven professional cricketers and 10 under-19 club-level cricketers performed the chop and lift, seated and standing cricket ball throw, seated and standing side medicine ball throw, and seated active thoracic rotation range of motion (ROM) and hip rotation ROM on one occasion. Participants were divided into 2 groups (fast and slow) based on their standing cricket ball–throwing velocity. The seated and standing cricket ball throw on the dominant side was significantly different (p \u3c 0.00) between fast and slow throwers (11.03 and 10.7 km·h-1, respectively). Muscular performance measures, such as bilateral thoracic rotation ROM, hip external rotation ROM on the dominant side, and force and work required in the chop, were significantly different (

Phasing for medical sequencing using rare variants and large haplotype reference panels.

Motivation: There is growing recognition that estimating haplotypes from high coverage sequencing of single samples in clinical settings is an important problem. At the same time very large datasets consisting of tens and hundreds of thousands of high-coverage sequenced samples will soon be available. We describe a method that takes advantage of these huge human genetic variation resources and rare variant sharing patterns to estimate haplotypes on single sequenced samples. Sharing rare variants between two individuals is more likely to arise from a recent common ancestor and, hence, also more likely to indicate similar shared haplotypes over a substantial flanking region of sequence.Results: Our method exploits this idea to select a small set of highly informative copying states within a Hidden Markov Model (HMM) phasing algorithm. Using rare variants in this way allows us to avoid iterative MCMC methods to infer haplotypes. Compared to other approaches that do not explicitly use rare variants we obtain significant gains in phasing accuracy, less variation over phasing runs and improvements in speed. For example, using a reference panel of 7420 haplotypes from the UK10K project, we are able to reduce switch error rates by up to 50% when phasing samples sequenced at high-coverage. In addition, a single step rephasing of the UK10K panel, using rare variant information, has a downstream impact on phasing performance. These results represent a proof of concept that rare variant sharing patterns can be utilized to phase large high-coverage sequencing studies such as the 100 000 Genomes Project dataset.</br

The Reliability of a Rotational Power Assessment of the Core

Context: Most athletic upper-body power generation involveshigh levels of neuromuscular activation/coordination of a rotationalnature. Therefore, it is important to assess athletic ability thatreplicates the rotational activity of athletes. However, a paucity ofresearch currently measures rotational power of the core.Objective: Establish inter-day reliability of chop and lift mean poweroutput via a linear position transducer on rotational reliant powerathletes.Design: Controlled laboratory study.Setting: Professional cricket training facilities.Population: Eight male professional cricket players (age= 23±3.38years, height= 186±10.06 cm, mass= 89.71± 8.12 kg) with aresistance (&gt;2 years) training background volunteered to participatein the study.Intervention: A linear position transducer was attached to theweight stack of a cable pulley system to determine the peak poweroutputs associated with a chop and lift movement. Assessmentoccurred on three occasions separated by at least seven days.Asymmetry, intraclass correlation coefficients (ICCs) and coefficientof variations (CV) were calculated and used to quantify the absoluteand relative consistency of the testing procedures.Results: The mean peak power outputs for chop and lift rangedfrom 404 - 494W and 277-314W respectively, the power outputsdiffering minimally (2.7-6.3%) between the left and right sides.Coefficients of variation of 7.4% - 19% were reported, with intraclass correlation coefficients of 0.54 - 0.94 observed betweentesting occasions.Conclusion: Mean muscular power output associated with the liftassessment reported greatest reliability in well trained athletes.The asymmetry between sides was relatively small suggestingbalanced multi-planar trunk development in the current throwingathletes. Equipment limitations (load related), training status andvariable selection (mean or peak power) need to be consideredprior to rotational assessment of the core.It is recommended that the lift movement is utilized in rotationalpower assessments, or that greater familiarization is undertakenwhen administering the chop assessment.KeywordsCore; Trunk; Assessment; Anaerobic; Transverse plan

Full thickness epidermal burn from a heating pad on a cesarean incision with silver dressing: a case report

We present a case of a full thickness epidermal burn resulting from an all-natural clay-based heating pad over a cesarean incision silver dressing to bring awareness to the risks associated with nonpharmacologic management of post cesarean pain. There is limited guidance on nonpharmacological management of post cesarean pain. It is important that providers are able to advise their patients about their options, including to be wary of using heating pads on post-cesarean dressings, especially with pain in the early post-partum period

A discrete time-dependent method for metastable atoms in intense fields

The full-dimensional time-dependent Schrodinger equation for the electronic dynamics of single-electron systems in intense external fields is solved directly using a discrete method. Our approach combines the finite-difference and Lagrange mesh methods. The method is applied to calculate the quasienergies and ionization probabilities of atomic and molecular systems in intense static and dynamic electric fields. The gauge invariance and accuracy of the method is established. Applications to multiphoton ionization of positronium and hydrogen atoms and molecules are presented. At very high intensity above saturation threshold, we extend the method using a scaling technique to estimate the quasienergies of metastable states of the hydrogen molecular ion. The results are in good agreement with recent experiments.Comment: 10 pages, 9 figure, 4 table

Exploring the interdependencies of research funders in the UK

Investment in medical research is vital to the continuing improvement of the UK's health and wealth. It is through research that we expand our understanding of disease and develop new treatments for patients. Medical research charities currently contribute over £1 billion annually to medical research in the UK, of which over £350 million is provided by Cancer Research UK. Many charities, including Cancer Research UK, receive no government funding for their research activity. Cancer Research UK is engaged in a programme of work in order to better understand the medical research funding environment and demonstrate the importance of sustained investment. A key part of that is the Office of Health Economics‟ (OHE) 2011 report “Exploring the interdependency between public and charitable medical research”. This study found that there are substantial benefits, both financial and qualitative, from the existence of a variety of funders and that reductions in the level of government financial support for medical research are likely to have broader negative effects. This contributed to other evidence which found that the activities and funding of the charity, public and private sectors respectively are complementary, i.e. mutually reinforcing, rather than duplicative or merely substituting for one another. “Exploring the interdependencies of research funders in the UK” by the Office of Health Economics (OHE) and SPRU: Science and Technology Policy Research at the University of Sussex, represents a continued effort to build the evidence base around the funding of medical research. This report uncovers the extent to which funders of cancer research are interdependent, nationally and internationally. Key figures show that two thirds of publications acknowledging external support have relied on multiple funders, while just under half benefited from overseas funding, and almost a fifth are also supported by industry. In addition the analysis shows that the general public would not want tax funding of cancer research to be reduced, but would not donate enough to charities to compensate for any such reduction