A Silicon Valley Life: A Silicon Valley Love Story

In the last three decades, Silicon Valley has become one of the world’s most watched and imitated communities. Daily news reporters, long-form journalists, cinema and television-programming producers have crafted a public image, but it represents nothing of the lives of hundreds of thousands of Valley residents. These fabrications obscure and diminish our complex human profile and reduce our uniquely beautiful geography to a place to generate financial profits, with all the damaging disregard such attitudes foster. The essays of A Silicon Valley Life: A Silicon Valley Love Story seek to show our true self: our rich mix of people drawn from all regions of Earth seeking a better life in a veritable Eden, which, even in the face of violent ecological degradation, remains beautiful and worthy of our greatest care. Home and homelessness are major themes of A Silicon Valley Life. The research relies on the fundamental tools of all great nonfiction writing: honest and prolonged observation of human action and self expression combined with deep reading and reporting of statistical fact and historic record to render insightful analysis and conclusions within a meaningful context. The essays and introduction should be read holistically, not unlike an impressionist or pointillist painting. The result renders a portrait of the people and place of Silicon Valley far closer to the real images and experiences that constitute our actual lives

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.

Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs\u27 therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less frequently. The majority of irAEs are mild to moderate in severity; however, serious and occasionally life-threatening irAEs are reported in the literature, and treatment-related deaths occur in up to 2% of patients, varying by ICI. Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. There is an urgent need for multidisciplinary guidance reflecting broad-based perspectives on how to recognize, report and manage organ-specific toxicities until evidence-based data are available to inform clinical decision-making. The Society for Immunotherapy of Cancer (SITC) established a multidisciplinary Toxicity Management Working Group, which met for a full-day workshop to develop recommendations to standardize management of irAEs. Here we present their consensus recommendations on managing toxicities associated with immune checkpoint inhibitor therapy

A Silicon Valley Life: A Silicon Valley Love Story

In the last three decades, Silicon Valley has become one of the world’s most watched and imitated communities. Daily news reporters, long-form journalists, cinema and television-programming producers have crafted a public image, but it represents nothing of the lives of hundreds of thousands of Valley residents. These fabrications obscure and diminish our complex human profile and reduce our uniquely beautiful geography to a place to generate financial profits, with all the damaging disregard such attitudes foster. The essays of A Silicon Valley Life: A Silicon Valley Love Story seek to show our true self: our rich mix of people drawn from all regions of Earth seeking a better life in a veritable Eden, which, even in the face of violent ecological degradation, remains beautiful and worthy of our greatest care. Home and homelessness are major themes of A Silicon Valley Life. The research relies on the fundamental tools of all great nonfiction writing: honest and prolonged observation of human action and self expression combined with deep reading and reporting of statistical fact and historic record to render insightful analysis and conclusions within a meaningful context. The essays and introduction should be read holistically, not unlike an impressionist or pointillist painting. The result renders a portrait of the people and place of Silicon Valley far closer to the real images and experiences that constitute our actual lives

The Curriculum – Iowa Star Schools project

This classic video provides a background on curriculum planning for distance educatio

Teaching and learning at a distance: foundations of distance education [Sixth Edition]

https://nsuworks.nova.edu/fse_facbooks/1082/thumbnail.jp

Teaching and learning at a distance : foundations of distance education /

Sixth edition

Alarmin function of galectin-9 in murine respiratory tularemia.

Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis. Here we show that Galectin-9, a host endogenous β-galactoside binding lectin, functions as an alarmin capable of mediating inflammatory response during sepsis resulting from pulmonary infection with Francisella novicida, a Gram negative bacterial pathogen. Our results show that this galectin is upregulated and is likely released during tissue damage in the lungs of F. novicida infected septic mice. In vitro, purified recombinant galectin-9 exacerbated F. novicida-induced production of the inflammatory mediators by macrophages and neutrophils. Concomitantly, Galectin-9 deficient (Gal-9-/-) mice exhibited improved lung pathology, reduced cell death and reduced leukocyte infiltration, particularly neutrophils, in their lungs. This positively correlated with overall improved survival of F. novicida infected Gal-9-/- mice as compared to their wild-type counterparts. Collectively, these findings suggest that galectin-9 functions as a novel alarmin by augmenting the inflammatory response in sepsis development during pulmonary F. novicida infection

Gal-9^-/- mice show improved survival during pulmonary F.n. infection.

<p><b>(A)</b> Fifteen each C57Bl/6 WT and Gal-9^-/- mice in 3 separate experiments (5 mice per experiment) were inoculated intranasally with F.n and were monitored daily for 2 weeks. The improved survival of Gal-9^-/- mice compared to WT mice was statistically significant, as determined by Kaplan-Meier log-rank analysis (<i>P</i> value*** = 0.0003). <b>(B)</b> Bacterial burdens in lungs, blood, spleen and liver harvested from F.n. infected WT and Gal-9^-/- mice at indicated times post-infection. Lung, liver and spleen homogenates prepared as described in Materials and Methods and blood were serially diluted and plated on TSA plates to enumerate bacterial burdens. Each symbol on the plots represents one mouse and data is from 2–3 independent experiments.</p

Gal-9^-/- mice exhibit improved lung pathology and reduced TUNEL staining indicative of cell death upon pulmonary F.n. infection.

<p><b>(A)</b> The lungs from F.n. infected wild-type (WT) or Gal-9^-/- mice were harvested at indicated times post-infection, embedded in optimal-cutting-temperature (OCT) compound, and sectioned as described in Materials and Methods. The frozen sections were stained with Hematoxylin and Eosin (H&E). The images obtained are representatives of three experiments performed with 3 mice per group in each experiment. Magnification, ×200. <b>(B)</b> H&E sections were scored in blinded fashion according to the following scoring scale: 0, no inflammatory cells (macrophages or neutrophils) present in section; 1, <5% of section infiltrated by inflammatory cells; 2, 5–10% of section infiltrated; 3, 20% of section infiltrate; and 4, >20% of section infiltrated. <b>(C)</b> Frozen lung sections from F.n. infected WT or Gal-9^-/- mice were processed for in-situ TUNEL staining for detection of DNA fragmentation (red) in nuclei. Nuclei (blue) were stained with 4′,6′-diamidino-2-phenylindole dilactate. Bar graph shows Mean fluorescence intensity (MFI) quantified using Image J software. Magnification, ×100.</p