2021-2022 New Friends Dreams and Directions

https://spiral.lynn.edu/foc-events/1038/thumbnail.jp

Speech Communication

Contains table of contents for Part IV, table of contents for Section 1 and reports on five research projects.Apple Computer, Inc.C.J. Lebel FellowshipNational Institutes of Health (Grant T32-NS07040)National Institutes of Health (Grant R01-NS04332)National Institutes of Health (Grant R01-NS21183)National Institutes of Health (Grant P01-NS23734)U.S. Navy / Naval Electronic Systems Command (Contract N00039-85-C-0254)U.S. Navy - Office of Naval Research (Contract N00014-82-K-0727

Speech Communication

Contains reports on five research projects.C.J. Lebel FellowshipNational Institutes of Health (Grant 5 T32 NSO7040)National Institutes of Health (Grant 5 R01 NS04332)National Institutes of Health (Grant 5 R01 NS21183)National Institutes of Health (Grant 5 P01 NS13126)National Institutes of Health (Grant 1 PO1-NS23734)National Science Foundation (Grant BNS 8418733)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0254)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0341)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0290)National Institutes of Health (Grant RO1-NS21183), subcontract with Boston UniversityNational Institutes of Health (Grant 1 PO1-NS23734), subcontract with the Massachusetts Eye and Ear Infirmar

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

AbstractThe identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded library technology (ELT). Initial efforts were focused on the efficient discovery of antibacterial leads against 119 targets from Acinetobacter baumannii and Staphylococcus aureus. The success of this effort led to the hypothesis that the relative number of ELT binders alone could be used to assess the ligandability of large sets of proteins. This concept was further explored by screening 42 targets from Mycobacterium tuberculosis. Active chemical series for six targets from our initial effort as well as three chemotypes for DHFR from M. tuberculosis are reported. The findings demonstrate that parallel ELT selections can be used to assess ligandability and highlight opportunities for successful lead and tool discovery.</jats:p

Combinations of block angles and lateral block spacings on sprint start time

The purpose of this investigation was to determine the sprint start time to the first 10 and to the second 10 meters as a result of alteration of starting block angles and lateral block spacings. One male world class, two female college level, one male and one female high school level sprinters served as subjects. During the test period each subject completed twelve 20-meter sprints. Sprint starts were made from combinations of 52.5, 65, and 75 degrees front starting block angle and 60 and 80 degrees rear starting block angle from a 4 inches and a 10 inches lateral block spacing. A subjects by treatments analysis of variance indicated a significant difference in time over the first 10 meters as a result of the alteration of block angle and lateral block spacing but no significant difference was obtained for the second 10-meter. Combination of 65 degrees front angle with 60 degrees rear block angle, and 75 degrees front angle with 60 degrees rear block angle were significantly different based on Duncan's new multiple range test. Significant difference in time by the subjects was found for all combinations of block angles for both the first 10 meters distance and for the second 10 meters distance. Based on Duncan's new multiple range test, male subjects performed significantly different than female subjects. A multiple linear regression procedure and a rank order correlation established that a significant difference existed in the independent variables that would predict the start time for the identified block combinations. FF2P, the second peak of resultant force of front foot, FVF2P, the second peak of vertical resultant force of front foot, and FRH, horizontal resultant force, were the independent variables most commonly identified although the contribution order was not the same. Little concordance existed in the rank of independent variables among the three significantly different combinations. Resultant force and resultant force angle, combinations of block angles and lateral block spacing, and sprint start time formed a mutual dependent relationship in this study. If an optimal model of statistical relationship between resultant force and resultant force angle, and combinations of block angles and lateral block spacing could be set up, the range of block angle and lateral block spacing variations could be minimized