27 research outputs found
2021-2022 New Friends Dreams and Directions
https://spiral.lynn.edu/foc-events/1038/thumbnail.jp
Speech Communication
Contains table of contents for Part IV, table of contents for Section 1 and reports on five research projects.Apple Computer, Inc.C.J. Lebel FellowshipNational Institutes of Health (Grant T32-NS07040)National Institutes of Health (Grant R01-NS04332)National Institutes of Health (Grant R01-NS21183)National Institutes of Health (Grant P01-NS23734)U.S. Navy / Naval Electronic Systems Command (Contract N00039-85-C-0254)U.S. Navy - Office of Naval Research (Contract N00014-82-K-0727
Speech Communication
Contains reports on five research projects.C.J. Lebel FellowshipNational Institutes of Health (Grant 5 T32 NSO7040)National Institutes of Health (Grant 5 R01 NS04332)National Institutes of Health (Grant 5 R01 NS21183)National Institutes of Health (Grant 5 P01 NS13126)National Institutes of Health (Grant 1 PO1-NS23734)National Science Foundation (Grant BNS 8418733)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0254)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0341)U.S. Navy - Naval Electronic Systems Command (Contract N00039-85-C-0290)National Institutes of Health (Grant RO1-NS21183), subcontract with Boston UniversityNational Institutes of Health (Grant 1 PO1-NS23734), subcontract with the Massachusetts Eye and Ear Infirmar
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
AbstractThe identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded library technology (ELT). Initial efforts were focused on the efficient discovery of antibacterial leads against 119 targets from Acinetobacter baumannii and Staphylococcus aureus. The success of this effort led to the hypothesis that the relative number of ELT binders alone could be used to assess the ligandability of large sets of proteins. This concept was further explored by screening 42 targets from Mycobacterium tuberculosis. Active chemical series for six targets from our initial effort as well as three chemotypes for DHFR from M. tuberculosis are reported. The findings demonstrate that parallel ELT selections can be used to assess ligandability and highlight opportunities for successful lead and tool discovery.</jats:p
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Combinations of block angles and lateral block spacings on sprint start time
The purpose of this investigation was to determine the
sprint start time to the first 10 and to the second 10
meters as a result of alteration of starting block angles
and lateral block spacings.
One male world class, two female college level, one
male and one female high school level sprinters served as
subjects. During the test period each subject completed
twelve 20-meter sprints. Sprint starts were made from combinations
of 52.5, 65, and 75 degrees front starting block
angle and 60 and 80 degrees rear starting block angle from a
4 inches and a 10 inches lateral block spacing.
A subjects by treatments analysis of variance indicated
a significant difference in time over the first 10 meters as
a result of the alteration of block angle and lateral block
spacing but no significant difference was obtained for the
second 10-meter. Combination of 65 degrees front angle with
60 degrees rear block angle, and 75 degrees front angle with
60 degrees rear block angle were significantly different based on Duncan's new multiple range test. Significant difference
in time by the subjects was found for all combinations
of block angles for both the first 10 meters distance
and for the second 10 meters distance. Based on Duncan's
new multiple range test, male subjects performed significantly
different than female subjects. A multiple linear
regression procedure and a rank order correlation established
that a significant difference existed in the independent
variables that would predict the start time for
the identified block combinations. FF2P, the second peak of
resultant force of front foot, FVF2P, the second peak of
vertical resultant force of front foot, and FRH, horizontal
resultant force, were the independent variables most commonly
identified although the contribution order was not the
same. Little concordance existed in the rank of independent
variables among the three significantly different combinations.
Resultant force and resultant force angle, combinations
of block angles and lateral block spacing, and sprint
start time formed a mutual dependent relationship in this
study.
If an optimal model of statistical relationship between
resultant force and resultant force angle, and combinations
of block angles and lateral block spacing could be set up,
the range of block angle and lateral block spacing variations
could be minimized