Impact of the COVID-19 pandemic on suicide rates in Japan through December 2021 : An interrupted time series analysis.

Acknowledgments This work is supported by a Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Award Number 21K10462). We thank Dr Paul Corcoran for kindly responding to our email questions about his paper, which was very useful in the analysis of this paper.Peer reviewedPublisher PD

Geography of suicide in Japan : spatial patterning and rural-urban differences.

Acknowledgements This work was supported by a Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Award Number 18K10080). Funding This work was supported by a Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Award Number 18K10080).Peer reviewedPublisher PD

Impact of HPV vaccine hesitancy on cervical cancer in Japan : a modelling study

Funding National Health and Medical Research Council Australia Centre of Research Excellence in Cervical Cancer Control, Japan Society for the Promotion of Science. Acknowledgments This study was part-funded via the National Health and Medical Research Council Australia Centre of Research Excellence in Cervical Cancer Control (C4; 1135172) and a grant-in-aid from the Japan Society for the Promotion of Science (16K15367).Peer reviewedPublisher PD

Relationships between road-distance to primary care facilities and ischemic heart disease and stroke mortality in Hokkaido, Japan : A Bayesian hierarchical approach to ecological count data.

ACKNOWLEDGEMENTS This work was supported by Grant-in-Aid for Scientific Research(C) (Grant Number 15K08797) from Japan Society for the Promotion of Science.Peer reviewedPublisher PD

Bivalent Human Papillomavirus Vaccine Effectiveness in a Japanese Population : High Vaccine-Type-Specific Effectiveness and Evidence of Cross-Protection

Acknowledgments.  We thank Dr Tomomi Egawa-Takata, Dr Akiko Morimoto, Dr Yusuke Tanaka, Ms Asami Yagi, Ms Yuka Watanabe, Ms Sachiko Ono, Ms Anna Ishida, and the administrators of Niigata, Nagaoka, Shibata, Sanjo, Joetsu, and Mitsuke cities for their support in conducting the survey. Financial support. This work was supported by the Health and Labor Sciences Research Grant (26272001) and the Japanese Agency for Medical Research and Development (AMED) under grant number JP15ck0106103 and JP17ck0106369.Peer reviewedPublisher PD

Risk factors for HPV infection and high-grade cervical disease in sexually active Japanese women

Funding Information: This work was supported by the Health and Labor Sciences Research Grant [26272001] and the Japanese Agency for Medical Research and Development [JP15ck0106103].Peer reviewedPublisher PD

Suspension of proactive recommendations for HPV vaccination has led to a significant increase in HPV infection rates in young Japanese women : real-world data

Funding Information: We would like to thank Ms. Yuka Watanabe, Ms. Sachiko Ono, Ms. Anna Ishida, and administrator of Niigata city for their support in conducting the survey. This work was supported by the Japanese Agency for Medical Research and Development (JP15ck0106103).Peer reviewedPublisher PD

B7H3 As a Promoter of Metastasis and Promising Therapeutic Target

B7H3 (also known as CD276, an immune checkpoint molecule) is aberrantly overexpressed in many types of cancer, and such upregulation is generally associated with a poor clinical prognosis. Recent discoveries indicate a crucial role for B7H3 in promoting carcinogenesis and metastasis. This review will focus on the latest developments relating specifically to the oncogenic activity of B7H3 and will describe the upstream regulators and downstream effectors of B7H3 in cancer. Finally, we discuss the emerging roles of microRNAs (miRNAs) in inhibiting B7H3-mediated tumor promotion. Excellent recent studies have shed new light on the functions of B7H3 in cancer and identified B7H3 as a critical promoter of tumor cell proliferation, migration, invasion, epithelial-to-mesenchymal transition, cancer stemness, drug resistance, and the Warburg effect. Numerous miRNAs are reported to regulate the expression of B7H3. Our meta-analysis of miRNA database revealed that 17 common miRNAs potentially interact with B7H3 mRNA. The analysis of the TCGA ovarian cancer dataset indicated that low miR-187 and miR-489 expression was associated with poor prognosis. Future studies aimed at delineating the precise cellular and molecular mechanisms underpinning B7H3-mediated tumor promotion will provide further insights into the cell biology of tumor development. In addition, inhibition of B7H3 signaling, to be used alone or in combination with other treatments, will contribute to improvements in clinical practice and benefit cancer patients

Correction : Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer.

This research was supported by a grant from the Department of Women’s Health Educational System, JSPS Grant-in-Aid for Scientific Research (C) (15K10697 and 16K11123) and the Science and Technology Planning Project of Guangdong Province, China (2014A020212124). We thank Dr. Zhujie Xu for experimental assistance. The authors declare that they have no conflict of interest.Peer reviewedPublisher PD