An Advanced Knowledge Based Graphical Authentication Framework with Guaranteed Confidentiality and Integrity

The information and security systems largely rely on passwords,which remain the fundamental part of any authentication process. The conventional authentication method based on alphanumerical username and password suffer from significant disadvantages. The graphical password-based authentication system has recently been introduced as an effective alternative. Although the graphical schemes effectively generate the passwords with better flexibility and enhanced security, the most common problem with this is the shoulder surfing attack. This paper proposes an effective 3D graphical password authentication system to overcome such drawbacks. The system is based on the selection of click points for generating passwords. The proposed work involved a training phase for evaluating the model in terms of the success rate. The overall evaluations of the model in terms of password entropy, password space, login success rates, and prediction probability in the shoulder surfing and guessing attacks proved that the model is more confidential and maintains a higher range of integrity than the other existing models

Attitude Towards Mental Illness Among Medical Students And Interns of a Medical College

  Introduction: Mental health and physical health are interconnected. Attitude of medical professionals towards mentally ill affects the quality of care the patient receives. Today’s medical students are tomorrow’s medical practitioner. We conducted a study in a teaching hospital to assess the attitude towards mental illness among medical students and interns. Methods: A descriptive cross sectional study was performed in 265 students in Kathmandu Medical College in August, 2017. Opinion about Mental Illness (OMI) questionnaire developed by Cohen and Struening was used. Results: Of the total participants, 49.8%(132) were male and 50.2%(133) were female. Medical students were more authoritarian, more benevolent and believed that mental illness is like any other medical illness. They showed neutral attitude in terms of social restriction of mentally ill and interpersonal relationship as a cause of mental illness. Conclusions: Positive attitude was seen only in terms of benevolence and mental hygiene ideology. Effective teaching and training programs is necessary to bring in positive attitude change towards mentally ill among medical students

Acetylation Regulates WRN Catalytic Activities and Affects Base Excision DNA Repair

Background: The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription. Methodology/Principal Findings: Here, we have investigated the p300 acetylation mediated changes on the function of WRN in base excision DNA repair (BER). We show that acetylation of WRN increases in cells treated with methyl methanesulfonate (MMS), suggesting that acetylation of WRN may play a role in response to DNA damage. This hypothesis is consistent with our findings that acetylation of WRN stimulates its catalytic activities in vitro and in vivo, and that acetylated WRN enhances pol b-mediated strand displacement DNA synthesis more than unacetylated WRN. Furthermore, we show that cellular exposure to the histone deacetylase inhibitor sodium butyrate stimulates long patch BER in wild type cells but not in WRN depleted cells, suggesting that acetylated WRN participates significantly in this process. Conclusion/Significance: Collectively, these results provide the first evidence for a specific role of p300 mediated WRN acetylation in regulating its function during BER

How a sports event can impact participants’ subjective well-being: The case of the Pacifi c Games – Samoa 2019

Large-scale events can affect the host economy, the natural environment, and the socio-cultural fabric of the host community. Given the significant finances required to host large scale sporting events, much of the initial research around sporting events involved estimating the economic impacts of hosting these events. More recently, there has been a shift in direction to examine the impacts of events on the host community’s subjective well-being. This research contributes to this area by using the 2019 Pacific Games as a case study held in Samoa. Using a quantitative survey instrument among Pacific Games attendees (N=334), this research assesses the extent to which perceived economic, socio-cultural, and environmental impacts, as a result of this sporting event, influence the attending residents’ subjective well-being. Data were collected via face-to-face interviews captured on tablets. Interviews were conducted at Games venues and commonly frequented locations around Samoa. The findings from this research can guide other SIDS when hosting sporting events and can serve as a benchmark to assess how future sporting events can motivate attendees to live healthier and more environmentally sustainable lifestyles. Unlike previous research, the conceptual framework includes assessing the likelihood of Games attendees’ intention to act in a pro-environmental way and their intention to implement a healthier lifestyle because of attending the Pacific Games

Neonatal Genetic Delivery of Anti-Respiratory Syncytial Virus (RSV) Antibody by Non-Human Primate-Based Adenoviral Vector to Provide Protection against RSV

Respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infection in infants. Immunoprophylaxis with the anti-RSV monoclonal antibody, palivizumab, reduces the risk for RSV-related hospitalizations, but its use is restricted to high-risk infants due to the high costs. In this study, we investigated if genetic delivery of anti-RSV antibody to neonatal mice by chimpanzee adenovirus type 7 expressing the murine form of palivizumab (AdC7αRSV) can provide protection against RSV. Intranasal and intramuscular administration of AdC7αRSV to adult mice resulted in similar levels of anti-RSV IgG in the serum. However, only intranasal administration resulted in detectable levels of anti-RSV IgG in the bronchoalveolar lavage fluid. Intranasal administration of AdC7αRSV provided protection against subsequent RSV challenge. Expression of the anti-RSV antibody was prolonged following intranasal administration of AdC7αRSV to neonatal mice. Protection against RSV was confirmed at 6 weeks of age. These data suggest that neonatal genetic delivery of anti-RSV antibody by AdC7αRSV can provide protection against RSV