Analysis of moderate subclinical hypothyroid patients with homeostatic model assessment-Insulin resistance

Aim: Homeostatic Model Assessment -Insulin Resistance- 2 test findings in people with mild hypothyroidism should be analyzed. Introduction: Hypothyroidism is associated with an increased risk of cardiovascular disease and alterations in blood lipidshave also been related to subclinical hypothyroidism. Treating hypothyroidism with levothyroxine (LT4) may help to improve lipid profiles and heart health, particularly in those with a wider deviation from the normal and higher blood TSH levels. Materials and Methods:There was a wide range of TSH levels among the study's participants, all of whom were between the ages of 20 and 45 and had never been diagnosed with thyroid disease. The study also included 50 people who had recently been diagnosed with moderate SCH but had not earlier been diagnosed with thyroid disease. Results: The glucose metabolism and insulin resistance are strongly influenced by thyroid hormones. Thyroid hormones. Participants in SCH were found to be more likely to be overweight or obese than those who did not participate in the research. TSH (r = 0.290; P\0.01) and LDL (r = 0.210; P\0.052) were shown to be significantly related in this study. SCH individuals had considerably higher LDL-cholesterol levels, according to this research

Role of Circulating Oxidized LDL: A Useful Diagnostic Risk Marker in Cardiovascular Disease

The aim: to assess levels of circulating plasma ox-LDL in various subgroups with different CVD and their relationship with oxidative stress markers, MDA, catalase, and traditional coronary disease risk factors. Material and methods: a total of 215 subjects divided into four groups comprising 54 healthy controls, patients with the SAP were 52 persons, with the UAP 53 ones, and with the AMI there were 56 persons, respectively. Lipid profile parameters (TC, TG, HDL-C, LDL-C, and VLDL-C), plasma MDA, catalase were estimated by kit methods, TBARS method, and colorimetric assay respectively. Plasma Ox-LDL was estimation by competitive ELISA kit method (Mercodia) with the help of specific monoclonal antibody mAb4Eb. Results were present as mean ± SD, significance level at p-values<0.05 with Student's unpaired t-test. Data analysis was performed by software package SPSS version 17.0. Results: it showed a highly significant (p<0.001) correlation in SAP, UAP, and AMI except for age in the SAP subgroup, moderately significant (p<0.01). Lipid profile except HDL-C was found highly elevated (p<0.001) in subgroups than in healthy controls. HDL-C was higher (p<0.001) in controls with respect to patient subgroups. Comparison of oxidative stress markers (MDA and catalase) and ox-LDH in control with patient's subgroup indicates highly significant (p<0.001) correlation. The correlation between SAP & UAP was insignificant (p<0.05), SAP with AMI was significant (p<0.05), and UAP & AMI were highly significant (p<0.001). Large interquartile range in SAP subgroup suggesting scattered deviation in the mean value as compared to UAP and AMI showed in the box and whiskers plot and concluded that significantly elevated level of ox-LDL in SAP, UAP, and AMI subgroups indicate its diagnostic importance of CVD. Conclusions: study concluded that significantly elevated level of ox-LDL in SAP, UAP, and AMI subgroups indicate its diagnostic importance of CVD

Analysis of Serum Sodium and Potassium Levels in Preeclampsia: An Institutional Based Study

Background: Preeclampsia is a syndrome characterized by hypertension, proteinuria and oedema. The present study was conducted to analyse Serum Sodium and Potassium Levels in Preeclampsia. Materials and Methods: It were a retrospective cross-sectional clinical study, carried out to analyse Serum Sodium and Potassium Levels in Preeclampsia. The results of 100 blood samples each of normotensives and preeclamptics women were included in the study. The measurement of serum sodium and potassium level was done. Statistical analysis was done. Results: In the present study results of 100 blood samples each of normotensives and preeclamptics women which came in the clinical lab for analyzing serum sodium and potassium levels over a period of 6 months were included in the study. The mean serum sodium levels in normotensives were 130.6mmol/l and in women with preeclampsia levels were 143.5mmol/l. The mean serum potassium levels in normotensives were 3.57 mmol/l and in women with preeclampsia levels were 2.67mmol/l. Conclusion: The present study concluded that the mean sodium levels were more in preeclampsia patients whereas the mean serum potassium levels were more in normotensives

Role of Circulating Oxidized LDL: A Useful Diagnostic Risk Marker in Cardiovascular Disease

The aim: to assess levels of circulating plasma ox-LDL in various subgroups with different CVD and their relationship with oxidative stress markers, MDA, catalase, and traditional coronary disease risk factors. Material and methods: a total of 215 subjects divided into four groups comprising 54 healthy controls, patients with the SAP were 52 persons, with the UAP 53 ones, and with the AMI there were 56 persons, respectively. Lipid profile parameters (TC, TG, HDL-C, LDL-C, and VLDL-C), plasma MDA, catalase were estimated by kit methods, TBARS method, and colorimetric assay respectively. Plasma Ox-LDL was estimation by competitive ELISA kit method (Mercodia) with the help of specific monoclonal antibody mAb4Eb. Results were present as mean ± SD, significance level at p-values<0.05 with Student's unpaired t-test. Data analysis was performed by software package SPSS version 17.0. Results: it showed a highly significant (p<0.001) correlation in SAP, UAP, and AMI except for age in the SAP subgroup, moderately significant (p<0.01). Lipid profile except HDL-C was found highly elevated (p<0.001) in subgroups than in healthy controls. HDL-C was higher (p<0.001) in controls with respect to patient subgroups. Comparison of oxidative stress markers (MDA and catalase) and ox-LDH in control with patient's subgroup indicates highly significant (p<0.001) correlation. The correlation between SAP & UAP was insignificant (p<0.05), SAP with AMI was significant (p<0.05), and UAP & AMI were highly significant (p<0.001). Large interquartile range in SAP subgroup suggesting scattered deviation in the mean value as compared to UAP and AMI showed in the box and whiskers plot and concluded that significantly elevated level of ox-LDL in SAP, UAP, and AMI subgroups indicate its diagnostic importance of CVD. Conclusions: study concluded that significantly elevated level of ox-LDL in SAP, UAP, and AMI subgroups indicate its diagnostic importance of CVD

A multicentric randomized clinical trial of homoeopathic medicines in fifty millesimal potencies vis-à -vis centesimal potencies on symptomatic uterine fibroids

Objective: The primary objective was to evaluate the effects of homoeopathic medicines in fifty millesimal (LM) potencies vis-à -vis centesimal (CH) potencies on symptomatic uterine fibroids. Materials and Methods: A multicentric randomized clinical trial was conducted at six centers under the Central Council for Research in Homoeopathy. Patients were screened for symptomatic uterine fibroids with the preset inclusion and exclusion criteria. A consultant specialized in obstetrics and gynecology was engaged at each center to screen and follow-up the enrolled patients. Homoeopathic physicians engaged in the study were responsible for prescription and follow up for 12 months. The primary outcome was changes in symptoms of uterine fibroid on a visual analog scale (VAS) of 0–10 and findings through ultrasonography (USG) between LM and CH potencies. The secondary outcome was to assess the changes in uterine fibroid symptom quality of life questionnaire (UFSQOL). Data analysis was done as per intention to treat (ITT) analysis. Results: Of 216 patients enrolled in the study (LM: 108 and CH: 108), 209 patients were analyzed under modified ITT (LM: 106, CH: 103). Both LM and CH potencies were equally effective in reducing the symptoms (percentage change) due to uterine fibroid on VAS scale after 1 year of treatment (P > 0.05). The health-related quality of life (HRQOL) and subdomains of UFSQOL also showed equal effectiveness in both the groups (P = 0.05). However, no difference was observed in all the USG findings except for uterine volume (P = 0.03). There was overall difference before and after homoeopathic treatment irrespective of assigned groups, i.e., LM or CH (P < 0.05) in all the above parameters. The medicines frequently prescribed were: Pulsatilla, Sulphur, Lycopodium, Sepia, Phosphorus, Calcarea carbonica, and Natrum muriaticum. Conclusion: LM and CH potencies are equally effective in giving symptomatic relief to patients suffering from symptomatic uterine fibroids