Realization of Zero-Refractive-Index Lens with Ultralow Spherical Aberration

Optical complex materials offer unprecedented opportunity to engineer fundamental band dispersion which enables novel optoelectronic functionality and devices. Exploration of photonic Dirac cone at the center of momentum space has inspired an exceptional characteristic of zero-index, which is similar to zero effective mass in fermionic Dirac systems. Such all-dielectric zero-index photonic crystals provide an in-plane mechanism such that the energy of the propagating waves can be well confined along the chip direction. A straightforward example is to achieve the anomalous focusing effect without longitudinal spherical aberration, when the size of zero-index lens is large enough. Here, we designed and fabricated a prototype of zero-refractive-index lens by comprising large-area silicon nanopillar array with plane-concave profile. Near-zero refractive index was quantitatively measured near 1.55 um through anomalous focusing effect, predictable by effective medium theory. The zero-index lens was also demonstrated to perform ultralow longitudinal spherical aberration. Such IC compatible device provides a new route to integrate all-silicon zero-index materials into optical communication, sensing, and modulation, and to study fundamental physics on the emergent fields of topological photonics and valley photonics.Comment: 14 pages, 4 figure

Polyp-PVT: Polyp Segmentation with Pyramid Vision Transformers

Most polyp segmentation methods use CNNs as their backbone, leading to two key issues when exchanging information between the encoder and decoder: 1) taking into account the differences in contribution between different-level features; and 2) designing an effective mechanism for fusing these features. Different from existing CNN-based methods, we adopt a transformer encoder, which learns more powerful and robust representations. In addition, considering the image acquisition influence and elusive properties of polyps, we introduce three novel modules, including a cascaded fusion module (CFM), a camouflage identification module (CIM), and a similarity aggregation module (SAM). Among these, the CFM is used to collect the semantic and location information of polyps from high-level features, while the CIM is applied to capture polyp information disguised in low-level features. With the help of the SAM, we extend the pixel features of the polyp area with high-level semantic position information to the entire polyp area, thereby effectively fusing cross-level features. The proposed model, named Polyp-PVT, effectively suppresses noises in the features and significantly improves their expressive capabilities. Extensive experiments on five widely adopted datasets show that the proposed model is more robust to various challenging situations (e.g., appearance changes, small objects) than existing methods, and achieves the new state-of-the-art performance. The proposed model is available at https://github.com/DengPingFan/Polyp-PVT.Comment: Technical Repor

Inf-Net: Automatic COVID-19 Lung Infection Segmentation from CT Images

© 1982-2012 IEEE. Coronavirus Disease 2019 (COVID-19) spread globally in early 2020, causing the world to face an existential health crisis. Automated detection of lung infections from computed tomography (CT) images offers a great potential to augment the traditional healthcare strategy for tackling COVID-19. However, segmenting infected regions from CT slices faces several challenges, including high variation in infection characteristics, and low intensity contrast between infections and normal tissues. Further, collecting a large amount of data is impractical within a short time period, inhibiting the training of a deep model. To address these challenges, a novel COVID-19 Lung Infection Segmentation Deep Network (Inf-Net) is proposed to automatically identify infected regions from chest CT slices. In our Inf-Net, a parallel partial decoder is used to aggregate the high-level features and generate a global map. Then, the implicit reverse attention and explicit edge-attention are utilized to model the boundaries and enhance the representations. Moreover, to alleviate the shortage of labeled data, we present a semi-supervised segmentation framework based on a randomly selected propagation strategy, which only requires a few labeled images and leverages primarily unlabeled data. Our semi-supervised framework can improve the learning ability and achieve a higher performance. Extensive experiments on our COVID-SemiSeg and real CT volumes demonstrate that the proposed Inf-Net outperforms most cutting-edge segmentation models and advances the state-of-the-art performance

Gold mineralized diorite beneath the Linglong ore field, North China craton: New insights into the origin of decratonization-related gold deposits

Gold deposits in Precambrian cratons were mostly generated during the formation and stabilization of the cratons, but the North China craton is unusual in that its gold deposits were mainly formed ∼1.7 b.y. after its stabilization. A magmatic-hydrothermal origin or mantle-derived fluid source has been proposed for the giant gold deposits of the Jiaodong District in the eastern North China craton, but direct evidence is sparse, and the mineralization processes remain controversial. Here, we present the results of a comprehensive geological, geochronological, and geochemical study of the gold mineralized Xiejia diorite beneath the Linglong ore field at Jiaodong to link the gold mineralization to underlying magmatism. Magmatic zircon and titanite grains from the Xiejia diorite have laser ablation−inductively coupled plasma−mass spectrometry (LA-ICP-MS) U-Pb ages of 121.3 ± 0.9 Ma to 120.8 ± 1.1 Ma and 121.7 ± 3.9 Ma, respectively, which are indistinguishable from the time of gold deposition throughout the Jiaodong District as constrained by previous studies. The diorite has a shoshonitic composition and is characterized by strong enrichment in large ion lithophile elements (LILEs) and light rare earth elements (LREEs) along with significant depletion in high field strength elements (HFSEs) and heavy rare earth elements (HREEs). Samples of the diorite have high initial 87Sr/86Sr ratios, but low εNd(t) and ɛHf(t) values and low Pb isotope ratios. These geochemical characteristics are akin to those of contemporaneous mafic dikes in most gold mines at Jiaodong, indicating that the Xiejia diorite was most likely derived from an enriched lithospheric mantle source. The upper part of the diorite intrusion is pervasively altered and mineralized, containing an average of 0.32 g/t Au, but locally up to 7.59 g/t. Hydrothermal titanite from the mineralized diorite has a LA-ICP-MS U-Pb age of 122.3 ± 4.3 Ma, which is consistent with the gold-bearing pyrite Re-Os isochron age of 122.5 ± 6.7 Ma. Ore-related sericite aggregates from the Dongfeng gold deposit above the Xiejia diorite have a 40Ar/39Ar plateau age of 122.6 ± 1.3 Ma. Pyrite from the mineralized diorite yielded δ34SCDT values of 2.1‰−9.7‰, which are comparable with those of pyrite (δ34SCDT = 5.8‰−8.1‰, where CDT indicates the Canyon Diablo troilite standard) from gold ores of Dongfeng. Pyrite grains from both groups also have similar Pb isotope compositions. The S and Pb isotope data are consistent with values of mafic dikes that are spatially and temporally associated with gold veins in the Linglong ore field. The results presented here thus indicate a possible genetic link between gold mineralization in the Xiejia diorite and underlying magma presumably represented by the Xiejia diorite. The auriferous fluids exsolved from that magma and migrated upward along the Potouqing fault to form the Dongfeng gold deposit above the Xiejia diorite. The mineralized diorite thus links shallow gold mineralization to deep-seated mantle-derived magmatism generated during the extensive destruction of the North China craton induced by the rollback of the subducted paleo-Pacific plate

Human pediculosis, a global public health problem

Background: Human pediculosis is caused by hematophagous lice, which are transmitted between individuals via direct and/or indirect contact. Despite the public health importance of louse infestation, information concerning the global burden of pediculosis and the epidemiological landscape of louse-borne diseases is limited. The aim of this review was to summarize the biology, epidemiology, diagnosis, and control of lice infestation in humans. We also discussed the latest advances in molecular taxonomy and molecular genetics of lice. Methods: We searched five electronic bibliographic databases (PubMed, ScienceDirect, CNKI, VIP Chinese Journal Database, and Wanfang Data) and followed a standard approach for conducting scoping reviews to identify studies on various aspects of human lice. Relevant information reported in the identified studies were collated, categorized, and summarized. Results: A total of 282 studies were eligible for the final review. Human pediculosis remains a public health issue affecting millions of people worldwide. Emerging evidence suggests that head lice and body lice should be considered conspecific, with different genotypes and ecotypes. Phylogenetic analysis based on mitochondrial (mt) cytb gene sequences identified six distinct clades of lice worldwide. In addition to the direct effect on human health, lice can serve as vectors of disease-causing pathogens. The use of insecticides plays a crucial role in the treatment and prevention of louse infestation. Genome sequencing has advanced our knowledge of the genetic structure and evolutionary biology of human lice. Conclusions: Human pediculosis is a public health problem affecting millions of people worldwide, particularly in developing countries. More progress can be made if emphasis is placed on the use of emerging omics technologies to elucidate the mechanisms that underpin the physiological, ecological, and evolutionary aspects of lice

Growth disturbance of extracts from several crops straw (residue) on Ageratina adenophora and biological-control implications in hazardous weed invasion for eco-restoration

Laboratory biological simulation experiment was conducted to investigate growth disturbance of high, moderate, low concentration of aqueous extracts (i.e. the original extracts with a solid liquid ratio of 1:40 g mL-1 and its 5 times diluents and 25 times diluents) from several crops straw (residue) on Ageratina adenophora, a worldwide notorious invasive weed. The results showed: (a) aqueous extracts from several crops straw (residue) brought about different impacts on the single index for germination and growth of A. adenophora, e.g., high concentration of aqueous extracts from Brassica oleracea waste leaves showed a strong inhibition against the germination rate (GR) and germination index (GI) of A. adenophora, while high concentration of aqueous extracts from Vicia cracca straw showed a strong inhibition against radicle length (RL) and hypocotyl length (HL) of A. adenophora; (b) high concentration of aqueous extracts from B. oleracea waste leaves and high, moderate and low concentration of aqueous extracts from Oryza sativa straw and Triticum aestivum straw showed rather strong synthetic effects (inhibition) on GR and GI of A. adenophora, which could be chosen for the control over the seeds germination of A. adenophora; (c) high and moderate concentrations of aqueous extracts from V. cracca straw, high concentration of aqueous extracts from B. campestris waste leaves, and moderate and low concentrations of aqueous extracts from O. sativa straw and T. aestivum straw showed rather strong synthetic effects (inhibition) on RL and HL of A. adenophora, which could be selected as ideal materials for the control over the seedlings growth of A. adenophora; and (d) high concentrations of aqueous extracts from V. cracca straw, B. oleracea waste leaves and B. campestris waste leaves, and high, moderate and low concentrations of aqueous extracts from O. sativa straw and T. aestivum straw showed rather strong synthetic effects (inhibition) on GR, GI, RL and HL of A. adenophora, which could be selected as ideal materials for the control over the seeds germination and seedlings growth of A. adenophora. Thus, this study would provide a theoretic guidance and technical support for the resources utilization of crops straw (residue) and the prevention and control over invasive weeds as well. (C) 2013 Elsevier B.V. All rights reserved.Laboratory biological simulation experiment was conducted to investigate growth disturbance of high, moderate, low concentration of aqueous extracts (i.e. the original extracts with a solid liquid ratio of 1:40 g mL-1 and its 5 times diluents and 25 times diluents) from several crops straw (residue) on Ageratina adenophora, a worldwide notorious invasive weed. The results showed: (a) aqueous extracts from several crops straw (residue) brought about different impacts on the single index for germination and growth of A. adenophora, e.g., high concentration of aqueous extracts from Brassica oleracea waste leaves showed a strong inhibition against the germination rate (GR) and germination index (GI) of A. adenophora, while high concentration of aqueous extracts from Vicia cracca straw showed a strong inhibition against radicle length (RL) and hypocotyl length (HL) of A. adenophora; (b) high concentration of aqueous extracts from B. oleracea waste leaves and high, moderate and low concentration of aqueous extracts from Oryza sativa straw and Triticum aestivum straw showed rather strong synthetic effects (inhibition) on GR and GI of A. adenophora, which could be chosen for the control over the seeds germination of A. adenophora; (c) high and moderate concentrations of aqueous extracts from V. cracca straw, high concentration of aqueous extracts from B. campestris waste leaves, and moderate and low concentrations of aqueous extracts from O. sativa straw and T. aestivum straw showed rather strong synthetic effects (inhibition) on RL and HL of A. adenophora, which could be selected as ideal materials for the control over the seedlings growth of A. adenophora; and (d) high concentrations of aqueous extracts from V. cracca straw, B. oleracea waste leaves and B. campestris waste leaves, and high, moderate and low concentrations of aqueous extracts from O. sativa straw and T. aestivum straw showed rather strong synthetic effects (inhibition) on GR, GI, RL and HL of A. adenophora, which could be selected as ideal materials for the control over the seeds germination and seedlings growth of A. adenophora. Thus, this study would provide a theoretic guidance and technical support for the resources utilization of crops straw (residue) and the prevention and control over invasive weeds as well. (C) 2013 Elsevier B.V. All rights reserved

Original Research MicroRNA-30a promotes invasiveness and metastasis in vitro and in vivo through epithelial-mesenchymal transition and results in poor survival of nasopharyngeal carcinoma patients

Abstract Although microRNA-30a (miR-30a) has been shown to regulate cancer metastasis, the molecular mechanism has not yet been clearly elucidated in nasopharyngeal carcinoma (NPC). The present study was to investigate the miR-30a expression pattern and its potential functions and further to identify its target gene and corresponding clinical applications in NPC. MiR-30a was identified to be down-regulated in NPC primary tumors compared with metastatic tumors using quantitative real-time PCR. Furthermore, over-expression of miR-30a transfected with precursor increased the ability of metastasis and invasion of NPC tumor cells in vivo and in vitro. E-cadherin was screened as a putative target gene of miR-30a by computational algorithms. Luciferase reporter assays showed that over-expression of miR-30a directly reduced the activity of a luciferase transcript combined with the 3 0 -untranslated region (3 0 -UTR) of E-cadherin. Kaplan-Meier survival analysis and log-rank test were analyzed for 1077 NPC patients for overall survival, indicating that a high expression of E-cadherin was beneficial for NPC prognosis (P ¼ 0.001). Importantly, NPC patients with high expression of E-cadherin had much lower risk of poor prognosis (hazard ratio ¼ 0.757, P ¼ 0.017) using multivariate analysis. In conclusion, miR-30a could play an important role in regulating NPC metastasis and potentially provide useful guidelines for individualized therapy