Heavy quarkonium production through the top quark rare decays via the channels involving flavor changing neutral currents

In the paper, we discuss the possibility of observation of heavy quarkoniums via the processes involving flavor changing neutral currents (FCNC). More explicitly, we systematically calculate the production of heavy charmonium and $(c\bar{b})$-quarkonium through the top quark semi-exclusive rare FCNC decays in the framework of the non-relativistic QCD (NRQCD) factorization theory. Our results show that the total decay widths $\Gamma_{t\to \eta_c} =1.20^{+1.04+1.14}_{-0.51-0.45}\times 10^{-16}$ GeV, $\Gamma_{t\to J/\psi} =1.37^{+1.03+1.30}_{-0.51-0.51}\times 10^{-16}$ GeV, $\Gamma_{t\to B_c}=2.06^{+0.17+0.91}_{-0.17-0.54}\times 10^{-18}$ GeV, and $\Gamma_{t\to B^*_c}=6.27^{+0.63+2.78}_{-0.62-1.64}\times 10^{-18}$ GeV, where the uncertainties are from variation of quark masses and renormalization scales. Even though the decay widths are small, it is important to make a systematic study on the production of charmonium and $(c\bar{b})$-quarkonium through the top-quark decays via FCNC in the Standard Model, which will provide useful guidance for future new physics research from the heavy quarkonium involved processes.Comment: 17 pages, 8 figures and 6 tables, to be published in European Physical Journal C. arXiv admin note: text overlap with arXiv:1304.1303 by other author

Clinical observation of macular grid photocoagulation before cataract surgery for diabetes patients with diffuse macular edema

AIM: To explore the effects and reliability of macular grid photocoagulation before cataract surgery for diabetes patients with diffuse macular edema.<p>METHODS: A total of 30 patients(40 eyes)were enrolled in the study. All the patients were randomly divided into two groups: group A: 20 eyes were treated with macular grid photocoagulation before cataract surgery; group B: 20 eyes were treated with cataract surgery only. <p>RESULTS: The patients treated with macular grid photocoagulation before cataract surgery. Postoperative visual acuity was improved, the edema of macular decreased. The patients treated with cataract surgery only, visual acuity showed no evident change and macular edema remained stable or creased. <p>CONCLUSION: Macular grid photocoagulation before cataract surgery for diabetes patients can improve the outcome and vision of the patients

The coal-forming environment during mass extinction in the latest permian: Evidence from geochemistry of rare Earth elements

The C1 coal of Latest Permian during mass extinction in eastern Yunnan was studied to reveal the terrestrial paleoenvironment and influence of geological events on coal-formation during mass extinction. An analysis of Rare Earth Elements (REEs) was conducted on the C1 coal from the Yantang Mine of Xuanwei, eastern Yunnan Province, which was deposited during the latest Permian. A total of 24 samples from coals, partings, roofs and floors from the C1 coal were taken from the fresh face in the underground mine. The results of the REEs analysis indicated that the total REE content (∑REE) in the C1 coal varies from 23.99 μg/g to 267.94 μg/g, averaged 122.69 μg/g. The C1 coal is enriched in light REE (LREE) relative to heavy REE (HREE), signifying the fractionation between LREE and HREE. Most samples of the coal seam C1 are depleted in Eu in various degrees and slightly depleted in Ce, especially two partings in sub-seams B1 and B3 which show the significant negative Eu anomalies. The geochemical characteristics of REE reveal that the C1 coal was deposited in a weak oxidation environment; the sedimentary environment was turbulent during the middle-later stage of coal-forming process; the C1 coal was affected by the basalt clastic materials from the Khangdian Oldland and acidic synsedimentary volcanic ash in the coal-forming period. The geochemical characteristics of Tonsteins in C1 coal are similar to those of marine Permian-Triassic boundary (PTB) volcanic ash layers in South China, which are both derived from the felsic volcanism caused by the closure of the Paleo-Tethys at the southwestern margin of the South China. Furthermore, the C1 coal was also affected by the eruption of Siberian large igneous province (SLIP) in the early stage

Holiday travel behavior analysis and empirical study under integrated multimodal travel information service

Holidays are special periods and give rise to many kinds of non-mandatory trips, such as shopping trips and tourist trips. This study investigates the relationship between Integrated Multimodal Travel Information (IMTI) service and holiday travel behavior characteristics in a trip chain. The Exploratory Factor Analysis (EFA) method is first used to extract the common factors based on the RP-SP fusion data under the pre-trip IMTI and en-route IMTI services, respectively. The Structural Equation Modeling (SEM) method is then applied to examine causal effects and quantitative relationships between the influencing factors and trip chain characteristics based on the EFA results. The results show that pre-trip IMTI has a significant negative effect on the holiday travel behavior. The more pre-trip IMTI is obtained by the traveler, the simpler the trip chain spatiotemporal and structural complexity will be. In addition, although the effect of en-route IMTI is less than pre-trip IMTI, it still plays an important role compared to other factors. Therefore, providing IMTI is a new and good alternative to alleviate holiday traffic congestions

Optical absorption of angulon in metal halide perovskites

We theoretically study the optical absorption of an angulon in the metal halide perovskites (MHP) based on the improved Devreese-Huybrechts-Lemmens model, where the formation of quasiparticle angulon states originates from the organic cation rotating in the inorganic octahedral cage of MHP. We find that the resonance optical absorption peaks are appeared when the energy of incident photon matches the quantum levels of angulon. Moreover, the intensity of absorption depends on the quantum states of phonon angular momentum. These theoretical results provide significant insight to study the redistribution of angular momenta for the rotational molecules immersed into the many-body environment.Comment: 10 pages, 2 figures, submitted to Phys. Rev. A (Welcome to comments

Comparative Proteomic Analysis of Panax ginseng C. A. Meyer × Panax quinquefolius L. Leaves and Parental Lines

Heterosis refers to the superior performance of heterozygous F1 hybrid plants with respect to those of their genetically distinct parents. Despite its wide use in crops, heterosis is seldom applied in the Panax genus, and its molecular basis remains unclear. Thus, this study is aimed to obtain hybrid F1s and identify the proteins associated with heterosis. Hybrid F1 plants and parental inbred lines were obtained using the embryo rescue technique, and the proteomes of their leaves were analyzed using two‐dimensional gel electrophoresis. A total of 236 differentially expressed proteins were found, among which 84 nonadditive proteins indicated a heterosis pattern in the hybrid. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analysis revealed that photosynthesis, carbohydrate metabolism, and protein and amino acid synthesis were the most abundant classes of nonadditive proteins. Of the proteins in these categories, 10, 6, and 4 proteins, respectively, showed above high parent expression in the hybrid leaves. These results imply that the increment in photosynthetic capacity, carbohydrate decomposition, and nitrogen fixation might be related to the heterosis of the hybrid biomass and ginsenoside production in the hybrid leaves. This study could provide a basis for hybrid breeding of the Panax genus

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.

The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number of LRAs have been found to reactivate latent HIV, they have not been used clinically due to high toxicity and poor efficacy. In this study, we report the identification of a chalcone analogue called Amt-87 that can significantly reactivate the transcription of latent HIV provirses and act synergistically with known LRAs such as prostratin and JQ1 to reverse latency. Amt-87 works by activating the human transcriptional elongation factor P-TEFb, a CDK9-cyclin T1 heterodimer that is part of the super elongation complex (SEC) used by the viral encoded Tat protein to activate HIV transcription. Amt-87 does so by promoting the phosphorylation of CDK9 at the T-loop, liberating P-TEFb from the inactive 7SK snRNP, and inducing the formation of the Tat-SEC complex at the viral promoter. Together, our data reveal chalcones as a promising category of compounds that should be further explored to identify effective LRAs for targeted reversal of HIV latency

DeepSec: a deep learning framework for secreted protein discovery in human body fluids

Motivation: Human proteins that are secreted into different body fluids from various cells and tissues can be promising disease indicators. Modern proteomics research empowered by both qualitative and quantitative profiling techniques has made great progress in protein discovery in various human fluids. However, due to the large number of proteins and diverse modifications present in the fluids, as well as the existing technical limits of major proteomics platforms (e.g. mass spectrometry), large discrepancies are often generated from different experimental studies. As a result, a comprehensive proteomics landscape across major human fluids are not well determined. Results: To bridge this gap, we have developed a deep learning framework, named DeepSec, to identify secreted proteins in 12 types of human body fluids. DeepSec adopts an end-to-end sequence-based approach, where a Convolutional Neural Network is built to learn the abstract sequence features followed by a Bidirectional Gated Recurrent Unit with fully connected layer for protein classification. DeepSec has demonstrated promising performances with average area under the ROC curves of 0.85–0.94 on testing datasets in each type of fluids, which outperforms existing state-of-the-art methods available mostly on blood proteins. As an illustration of how to apply DeepSec in biomarker discovery research, we conducted a case study on kidney cancer by using genomics data from the cancer genome atlas and have identified 104 possible marker proteins