Strategic Asset Seeking and Innovation Performance: The Role of Innovation Capabilities and Host Country Institutions

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Derivation of Electroweak Chiral Lagrangian from One Family Technicolor Model

Based on previous studies deriving the chiral Lagrangian for pseudo scalar mesons from the first principle of QCD in the path integral formalism, we derive the electroweak chiral Lagrangian and dynamically compute all its coefficients from the one family technicolor model. The numerical results of the $p^4$ order coefficients obtained in this paper are proportional to the technicolor number $N_{\rm TC}$ and the technifermion number $N_{\rm TF}$, which agrees with the arguments in previous works, and which confirms the reliability of this dynamical computation.Comment: 6 page

Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: A case report

Background: Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. Recent investigations revealed that a highly conserved glycine-leucine-tryptophan (115G-L-W117) motif in the first extracellular segment (ESC1) of claudin 16 might be essential for stabilization of the appropriately folded ECS1 structure and conservation of normal claudin 16 function. However, neither missense nor nonsense mutation has ever been described in this motif. Our study aimed at identifying mutations in a Chinese patient with FHHNC and exploring the association between genotype and phenotype. Case presentation: A 33-year-old female presented with 4 years history of recurrent acute pyelonephritis without other notable past medical history. Her healthy parents, who aged 56 and 53 respectively, were second cousins, and her only sibling died from renal failure without definite cause at age 25. Renal ultrasound imaging demonstrated atrophic kidneys and bilateral nephrocalcinosis. The laboratory workup revealed impaired renal function (Stage CKD IV), hypocalcemia and mild hypomagnesemia, accompanied with marked renal loss of magnesium and hypercalciuria. During the follow-up, treatment with calcitriol and calcium but not with magnesium was difficult to achieve normal serum calcium levels, whereas her serum magnesium concentration fluctuated within normal ranges. In the end, the patient unavoidably reached ESRD at 36 years old. The clinical features and family history suggested the diagnosis of FHHNC. To make a definite diagnosis, we use whole-exome sequencing to identify the disease-causing mutations and Sanger sequencing to confirm the mutation co-segregation in the family. As a result, a novel homozygous mutation (c.346C > G, p.Leu116Val) in115G-L-W117motif of claudin 16 was identified. Her parents, grandmother and one of her cousins carried heterozygous p.Leu116Val, whereas 200 unrelated controls did not carry this mutation. Conclusions: We described a delayed diagnosis patient with FHHNC in the Chinese population and identified a novel missense mutation in the highly conserved115G-L-W117motif of claudin 16 for the first time. According to the reported data and the information deduced from 3D modeling, we speculate that this mutation probably reserve partial residual function which might be related to the slight phenotype of the patient

Efficient Search and Localization of Human Actions in Video Databases

As digital video databases grow, so grows the problem of effectively navigating through them. In this paper we propose a novel content-based video retrieval approach to searching such video databases, specifically those involving human actions, incorporating spatio-temporal localization. We outline a novel, highly efficient localization model that first performs temporal localization based on histograms of evenly spaced time-slices, then spatial localization based on histograms of a 2-D spatial grid. We further argue that our retrieval model, based on the aforementioned localization, followed by relevance ranking, results in a highly discriminative system, while remaining an order of magnitude faster than the current stateof- the-art method. We also show how relevance feedback can be applied to our localization and ranking algorithms. As a result, the presented system is more directly applicable to real-world problems than any prior content-based video retrieval system

Microwave Slow-Wave Structure and Phase-Compensation Technique for Microwave Power Divider

In this paper, T-shaped electromagnetic bandgap is loaded on a coupled transmission line itself and its electric performance is studied. Results show that microwave slow-wave effect can be enhanced and therefore, size reduction of a transmission-line-based circuit is possible. However, the transmission-line-based circuits characterize varied phase responses against frequency, which becomes a disadvantage where constant phase response is required. Consequently, a phase-compensation technique is further presented and studied. For demonstration purpose, an 8-way coupled-line power divider with 22.5 degree phase shifts between adjacent output ports, based on the studied slow-wave structure and phase-compensation technique, is developed. Results show both compact circuit architecture and improved phase imbalance are realized, confirming the investigated circuit structures and analyzing methodologies