Noun animacy as a factor in the production of L2 English passives by L1 Mandarin learners

Shanshan investigates whether there is a greater likelihood of producing passives with animate (as opposed to inanimate) patients being placed in the grammatical subject position during syntactic priming activities.https://egrove.olemiss.edu/gscalt/1000/thumbnail.jp

FBXO11 (F-box protein 11)

FBXO11 is a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, named the F-box domain. It is the substrate binding subunit of the SKP1-CUL1-F-box (SCF) ubiquitin ligase complex. FBXO11 is conserved from nematodes to mammals, and both human FBXO11 and its worm ortholog (DRE-1) form functional SCF ubiquitin ligase complexes. By binding to and mediating the degradation of its substrate proteins, FBXO11 plays important roles in regulating cell cycle regulation, tumorigenesis, and tumor cell metastasis. The gene encoding FBXO11 was found to be deleted or mutated in various types of human tumors

Partial Signatures and their Applications

We introduce Partial Signatures, where a signer, given a message, can compute a ``stub\u27\u27 which preserves her anonymity, yet later she, but nobody else, can complete the stub to a full and verifiable signature under her public key. We provide a formal definition requiring three properties, namely anonymity, unambiguity and unforgeability. We provide schemes meeting our definition both with and without random oracles. Our schemes are surprisingly cheap in both bandwidth and computation. We describe applications including anonymous bidding and betting

Key Insulation and Intrusion Resilience Over a Public Channel

Key insulation (KI) and Intrusion resilience (IR) are methods to protect a user\u27s key against exposure by utilizing periodic communications with an auxiliary helper. But existing work assumes a secure channel between user and helper. If we want to realize KI or IR in practice we must realize this secure channel. This paper looks at the question of how to do this when the communication is over what we are more likely to have in practice, namely a public channel such as the Internet or a wireless network. We explain why this problem is not trivial, introduce models and definitions that capture the desired security in a public channel setting, and provide a complete (and surprising) answer to the question of when KI and IR are possible over a public channel. The information we provide is important to guide practitioners with regard to the usage of KI and IR and also to guide future research in this area

Psychological Status of High School Students 1 Year After the COVID-19 Emergency

Background: With the control of the epidemic, adolescents\u27 mental outlook might have improved. However, little evidence existed with regard to the psychological status of adolescents in post-COVID-19 era. This present study aimed to explore the psychological status of high school students after the epidemic getting eased. Methods: A web-based cross-sectional survey was used to obtain data from three high schools, including the demographic information, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Self-Rating Scale of Sleep (SRSS), and self-designed general recent-status questionnaire. Correlation analysis was performed to explore potential associations between the depression symptoms, anxiety symptoms, and sleep status. The PHQ-9 and GAD-7 differences between nowadays data and the data enrolled 12 months before were also compared. Result: A total of 1,108 qualified questionnaires were obtained. The prevalence of depressive and anxious symptoms was 27.5 and 21.3%, respectively, from mild to severe in all students, while 11.8% of these high students got sleep disturbances. Both the rate and the severity of depression, anxiety and sleep problems of female students were higher than male students. Grade three students suffered higher prevalence and severer mental disturbances than the other two grades. There were significant correlations between the depression symptoms, anxiety symptoms, and sleep status. The psychological status has been improved in nowadays high school students compared with the sample enrolled 12 months before. Conclusion: As a supplement to our former study, this present research provided a perspective on the psychological status of high school students 1 year after the COVID-19 pandemic being well controlled. We should pay attention to the psychological status of high school students, and should also notice the progresses made by this special group after the epidemic

Prevalence of Depression and Anxiety Symptoms of High School Students in Shandong Province During the COVID-19 Epidemic

© Copyright © 2020 Zhang, Zhai, Yang, Zhang, Zhou, Yang, Duan and Zhou. Background: The coronavirus disease 2019 (covid-19) has brought physical risks as well as psychological challenges to the whole world. High school students are a special group suffering from both the academic pressure and the threat of the epidemic. The present study aims to conduct an online survey to investigate the psychological status of high school students in Shandong Province. Methods: Using a web-based cross-sectional survey, data was collected from 1,018 voluntary high school students assessed with demographic information, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7) and a self-designed online-study effect survey. Correlation analysis was performed to explore the relationships between depression symptoms, anxiety symptoms, and study effect. Result: The prevalence of depressive symptoms, anxiety symptoms, and a combination of depressive and anxiety symptoms was 52.4, 31.4, and 26.8%, respectively, among high school students in Shandong Province during the COVID-19 epidemic. And from moderate to severe severity level, the rates of depressive symptoms and anxious symptoms were 17.6 and 4.6%. Female students exhibited a higher rate and severity of mental symptoms than male, and grade one senior high school students got a higher rate and severity of mental symptoms than the other two grades. Nearly half of the students were not satisfied with their online-study effect. The PHQ-9 score had a strong positive correlation with the GAD-7 score. Both the PHQ-9 score the GAD-7 score had a negative correlation with the study-effect survey score. Conclusion: Quite a number of high school students suffered from depression and anxiety symptoms during the COVID-19 epidemic. Sufficient attentions should be paid, and necessary supports should be provided, to protect the mental health of this special group

Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase

F-box proteins and DCAF proteins are the substrate binding subunits of the Skp1-Cul1-F-box protein (SCF) and Cul4-RING protein ligase (CRL4) ubiquitin ligase complexes, respectively. Using affinity purification and mass spectrometry, we determined that the F-box protein FBXO11 interacts with CDT2, a DCAF protein that controls cell-cycle progression, and recruits CDT2 to the SCF(FBXO11)complex to promote its proteasomal degradation. In contrast to most SCF substrates, which exhibit phosphodegron-dependent binding to F-box proteins, CDK-mediated phosphorylation of Thr464 present in the CDT2 degron inhibits recognition by FBXO11. Finally, our results show that the functional interaction between FBXO11 and CDT2 is evolutionary conserved from worms to humans and plays an important role in regulating the timing of cell-cycle exit.Fil: Rossi, Mario. University Of New York; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; ArgentinaFil: Duan, Shanshan. University Of New York; Estados Unidos. Howard Hughes Medical Institute; Estados UnidosFil: Jeong, Yeon Tae. University Of New York; Estados UnidosFil: Horn, Moritz. Max Planck Institute for Biology of Ageing; Alemania. University of Cologne; AlemaniaFil: Saraf, Anita. The Stowers Institute for Medical Research; Estados UnidosFil: Florens, Laurence. The Stowers Institute for Medical Research; Estados UnidosFil: Washburn, Michael P.. The Stowers Institute for Medical Research; Estados Unidos. University of Kansas; Estados UnidosFil: Antebi, Adam. Max Planck Institute for Biology of Ageing; Alemania. University of Cologne; AlemaniaFil: Pagano, Michele. University Of New York; Estados Unidos. Howard Hughes Medical Institute; Estados Unido