276 research outputs found
A Novel Approach using Liquid Embolic Agent for the Treatment of Pancreatic-Cutaneous Fistulas: Report of a Case
Pancreatic fistula formation remains one of the most dreadful complications after pancreaticoduodenectomies, resulting in extended hospital stays, increased healthcare costs, along with significantly increased morbidity and mortality. Little is mentioned in the literature about the use of percutaneous techniques to resolve this complication when conservative treatments fail. Thus, we developed a novel technique for treating pancreatic-cutaneous fistulas that develop post-pancreaticoduodenectomy. This work describes a novel approach of using a liquid embolic agent to treat a high-output pancreatic-cutaneous fistula after a Whipple procedure, which to the best of our knowledge after extensive literature searches, has not been performed before
Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice.
The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion. Kiss1-syntheizing neurons reside primarily in the hypothalamic anteroventral periventricular (AVPV/PeN) and arcuate (ARC) nuclei. AVPV/PeN Kiss1 neurons are sexually dimorphic, with females expressing more Kiss1 than males, and participate in estradiol (E2)-induced positive feedback control of GnRH secretion. In mice, most AVPV/PeN Kiss1 cells coexpress tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis (in this case, dopamine). Dopamine treatment can inhibit GnRH neurons, but the function of dopamine signaling arising specifically from AVPV/PeN Kiss1 cells is unknown. We generated a novel TH flox mouse and used Cre-Lox technology to selectively ablate TH specifically from Kiss1 cells. We then examined the effects of selective TH knock-out on puberty and reproduction in both sexes. In control mice, 90% of AVPV/PeN Kiss1 neurons coexpressed TH, whereas in mice lacking TH exclusively in Kiss1 cells (termed Kiss THKOs), TH was successfully absent from virtually all Kiss1 cells. Despite this absence of TH, both female and male Kiss THKOs displayed normal body weights, puberty onset, and basal gonadotropin levels in adulthood, although testosterone (T) was significantly elevated in adult male Kiss THKOs. The E2-induced LH surge was unaffected in Kiss THKO females, and neuronal activation status of kisspeptin and GnRH cells was also normal. Supporting this, fertility and fecundity were normal in Kiss THKOs of both sexes. Thus, despite high colocalization of TH and Kiss1 in the AVPV/PeN, dopamine produced in these cells is not required for puberty or reproduction, and its function remains unknown
Maximum Power Efficiency and Criticality in Random Boolean Networks
Random Boolean networks are models of disordered causal systems that can
occur in cells and the biosphere. These are open thermodynamic systems
exhibiting a flow of energy that is dissipated at a finite rate. Life does work
to acquire more energy, then uses the available energy it has gained to perform
more work. It is plausible that natural selection has optimized many biological
systems for power efficiency: useful power generated per unit fuel. In this
letter we begin to investigate these questions for random Boolean networks
using Landauer's erasure principle, which defines a minimum entropy cost for
bit erasure. We show that critical Boolean networks maximize available power
efficiency, which requires that the system have a finite displacement from
equilibrium. Our initial results may extend to more realistic models for cells
and ecosystems.Comment: 4 pages RevTeX, 1 figure in .eps format. Comments welcome, v2: minor
clarifications added, conclusions unchanged. v3: paper rewritten to clarify
it; conclusions unchange
Mining and Analyzing the Italian Parliament: Party Structure and Evolution
The roll calls of the Italian Parliament in the XVI legislature are studied
by employing multidimensional scaling, hierarchical clustering, and network
analysis. In order to detect changes in voting behavior, the roll calls have
been divided in seven periods of six months each. All the methods employed
pointed out an increasing fragmentation of the political parties endorsing the
previous government that culminated in its downfall. By using the concept of
modularity at different resolution levels, we identify the community structure
of Parliament and its evolution in each of the considered time periods. The
analysis performed revealed as a valuable tool in detecting trends and drifts
of Parliamentarians. It showed its effectiveness at identifying political
parties and at providing insights on the temporal evolution of groups and their
cohesiveness, without having at disposal any knowledge about political
membership of Representatives.Comment: 27 pages, 14 figure
Computational simulation of the predicted dosimetric impact of adjuvant yttrium-90 PET/CT-guided percutaneous ablation following radioembolization
Background: 90Y PET/CT post-radioembolization imaging has demonstrated that the distribution of 90Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact of post-treatment 90Y PET/CT-guided percutaneous ablation of the portions of a tumor receiving the lowest absorbed dose. A cohort of fourteen patients with non-resectable liver cancer previously treated using 90Y radioembolization were included in this retrospective study. Each patient exhibited potentially under-treated areas of tumor following treatment based on quantitative 90Y PET/CT. 90Y PET/CT was used to guide electrode placement for simulated adjuvant radiofrequency ablation in areas of tumor receiving the lowest dose. The finite element method was used to solve Penne’s bioheat transport equation, coupled with the Arrhenius thermal cell-death model to determine 3D thermal ablation zones. Tumor and unablated tumor absorbed-dose metrics (average dose, D50, D70, D90, V100) following ablation were compared, where D70 is the minimum dose to 70% of tumor and V100 is the fractional tumor volume receiving more than 100 Gy.
Results: Compared to radioembolization alone, 90Y radioembolization with adjuvant ablation was associated with predicted increases in all tumor dose metrics evaluated. The mean average absorbed dose increased by 11.2 ± 6.9 Gy. Increases in D50, D70, and D90 were 11.0 ± 6.9 Gy, 13.3 ± 10.9 Gy, and 11.8 ± 10.8 Gy, respectively. The mean increase in V100 was 7.2 ± 4.2%. All changes were statistically significant (P \u3c 0.01). A negative correlation between pre-ablation tumor volume and D50, average dose, and V100 was identified (ρ \u3c − 0.5, P \u3c 0.05) suggesting that adjuvant radiofrequency ablation may be less beneficial to patients with large tumor burdens.
Conclusions: This study has demonstrated that adjuvant 90Y PET/CT-guided radiofrequency ablation may improve tumor absorbed-dose metrics. These data may justify a prospective clinical trial to further evaluate this hybrid approach
Complexity and Information: Measuring Emergence, Self-organization, and Homeostasis at Multiple Scales
Concepts used in the scientific study of complex systems have become so
widespread that their use and abuse has led to ambiguity and confusion in their
meaning. In this paper we use information theory to provide abstract and
concise measures of complexity, emergence, self-organization, and homeostasis.
The purpose is to clarify the meaning of these concepts with the aid of the
proposed formal measures. In a simplified version of the measures (focusing on
the information produced by a system), emergence becomes the opposite of
self-organization, while complexity represents their balance. Homeostasis can
be seen as a measure of the stability of the system. We use computational
experiments on random Boolean networks and elementary cellular automata to
illustrate our measures at multiple scales.Comment: 42 pages, 11 figures, 2 table
Punctuated equilibria and 1/f noise in a biological coevolution model with individual-based dynamics
We present a study by linear stability analysis and large-scale Monte Carlo
simulations of a simple model of biological coevolution. Selection is provided
through a reproduction probability that contains quenched, random interspecies
interactions, while genetic variation is provided through a low mutation rate.
Both selection and mutation act on individual organisms. Consistent with some
current theories of macroevolutionary dynamics, the model displays
intermittent, statistically self-similar behavior with punctuated equilibria.
The probability density for the lifetimes of ecological communities is well
approximated by a power law with exponent near -2, and the corresponding power
spectral densities show 1/f noise (flicker noise) over several decades. The
long-lived communities (quasi-steady states) consist of a relatively small
number of mutualistically interacting species, and they are surrounded by a
``protection zone'' of closely related genotypes that have a very low
probability of invading the resident community. The extent of the protection
zone affects the stability of the community in a way analogous to the height of
the free-energy barrier surrounding a metastable state in a physical system.
Measures of biological diversity are on average stationary with no discernible
trends, even over our very long simulation runs of approximately 3.4x10^7
generations.Comment: 20 pages RevTex. Minor revisions consistent with published versio
Self-optimization, community stability, and fluctuations in two individual-based models of biological coevolution
We compare and contrast the long-time dynamical properties of two
individual-based models of biological coevolution. Selection occurs via
multispecies, stochastic population dynamics with reproduction probabilities
that depend nonlinearly on the population densities of all species resident in
the community. New species are introduced through mutation. Both models are
amenable to exact linear stability analysis, and we compare the analytic
results with large-scale kinetic Monte Carlo simulations, obtaining the
population size as a function of an average interspecies interaction strength.
Over time, the models self-optimize through mutation and selection to
approximately maximize a community fitness function, subject only to
constraints internal to the particular model. If the interspecies interactions
are randomly distributed on an interval including positive values, the system
evolves toward self-sustaining, mutualistic communities. In contrast, for the
predator-prey case the matrix of interactions is antisymmetric, and a nonzero
population size must be sustained by an external resource. Time series of the
diversity and population size for both models show approximate 1/f noise and
power-law distributions for the lifetimes of communities and species. For the
mutualistic model, these two lifetime distributions have the same exponent,
while their exponents are different for the predator-prey model. The difference
is probably due to greater resilience toward mass extinctions in the food-web
like communities produced by the predator-prey model.Comment: 26 pages, 12 figures. Discussion of early-time dynamics added. J.
Math. Biol., in pres
The Grizzly, October 28, 2004
Don\u27t Let Wismer Food Scare You; DSAC is Here to Help! • Senior Halloween Party Coming to a Barn Near You • RHA Halloween Decorating Contest Returns • Halloween not for Everyone • Omwake, a Haunted House for the Community • Cheap, Last-minute Costumes Down the Road • It\u27s a Witch! • Hobson Ghosts: Past and Present • Eastern State Penitentiary: Does it Frighten You? • Opinions: Are Halloween Costumes Just for Fun, or Can They be Offensive?; How Old is Too Old to Trick or Treat?; Halloween Hijinks • The Thompson-Gay Era and the Gym Named in Their Honor • Nightmares on Broad Streethttps://digitalcommons.ursinus.edu/grizzlynews/1569/thumbnail.jp
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