Evolution and Medicine: The Long Reach of Dr. Darwin

In this review we consider the new science of Darwinian medicine. While it has often been said that evolutionary theory is the glue that holds the disparate branches of biological inquiry together and gives them direction and purpose, the links to biomedical inquiry have only recently been articulated in a coherent manner. Our aim in this review is to make clear first of all, how evolutionary theory is relevant to medicine; and secondly, how the biomedical sciences have enriched our understanding of evolutionary processes. We will conclude our review with some observations of the philosophical significance of this interplay between evolutionary theory and the biomedical sciences

Evolution and medicine: the long reach of "Dr. Darwin"

In this review we consider the new science of Darwinian medicine. While it has often been said that evolutionary theory is the glue that holds the disparate branches of biological inquiry together and gives them direction and purpose, the links to biomedical inquiry have only recently been articulated in a coherent manner. Our aim in this review is to make clear first of all, how evolutionary theory is relevant to medicine; and secondly, how the biomedical sciences have enriched our understanding of evolutionary processes. We will conclude our review with some observations of the philosophical significance of this interplay between evolutionary theory and the biomedical sciences

Are animal models predictive for humans?

It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one empirically analyzes animal models using scientific tools they fall far short of being able to predict human responses. This is not surprising considering what we have learned from fields such evolutionary and developmental biology, gene regulation and expression, epigenetics, complexity theory, and comparative genomics

Biochemical Reductionism in Biological Context

Attempts to reduce biological systems to the level of simple physico-chemical processes have failed because during the reduction the systems lost their specifically biological properties. Living systems have numerous properties that are simply not found in the inanimate world

Axiomatic Quantum Mechanics and Radioactive Decay

This paper explores the consequences of the orthodox resolution of the measurement problem for the axiomatic base of non-relativistic elementary quantum mechanics. It is argued that the standard resolution of the measurement problem generates a paradox whose dissolution may be achieved through an enrichment of the axiomatic foundations of quantum mechanics. These results are also linked to some recent creative proposals by Nancy Cartwright concerning the nature of the so-called reduction of the wave packet

Time and the Propensity Interpretation of Probability

The prime concern of this paper is with the nature of probability. It is argued that questions concerning the nature of probability are intimately linked to questions about the nature of time. The case study here concerns the single case propensity interpretation of probability. It is argued that while this interpretation of probability has a natural place in the quantum theory, the metaphysical picture of time to be found in relativity theory is incompatible with such a treatment of probability