A Comparative Analysis of Soccer Skill Tests on Varying Experience Levels

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Spontaneous cerebellar hemorrhage in a patient taking apixaban

AbstractObjectivesAtrial fibrillation is closely associated with cardioembolic stroke. Until recently, warfarin has been the gold standard for the treatment of atrial fibrillation. Since 2010 the United States Food and Drug Administration has approved three new agents for anticoagulation in patients with atrial fibrillation. The purpose of this case report is to discuss some of the practical implications for using these agents.MethodsA patient taking apixaban presented with a spontaneous cerebellar hemorrhage. While the patient was initially considered a candidate for surgical intervention, the lack of literature addressing surgical intervention in patients on novel anticoagulation clouded the clinical decision-making. The patient was ultimately managed with administration of activated prothrombin complex concentrate, blood pressure control, frequent clinical assessments and airway protection. The patient did not undergo craniotomy for hematoma evacuation.ConclusionsRecent FDA approval of several novel oral anticoagulants for use in patients with atrial fibrillation has resulted in a significant number of patients formerly treated with warfarin being switched to these newer agents. There remains a lack of clear guidelines for the management of hemorrhagic complications. This case report describes one management strategy and highlights the paucity of current evidence to support critical clinical decisions

Public Input for City Budgeting Using E-Input, Face-to-Face Discussions, and Random Sample Surveys: The Willingness of an American Community to Increase Taxes

Regular public input into a city\u27s budget is frequently associated with municipal budgeting in Brazilian cities, successes in public engagement that have been emulated around the world. American communities are adopting the practice to varying degrees. This paper will report on a five-year old public input program that is taking place in Lincoln, Nebraska, the capital city of a politically conservative state in the U.S. We discuss the processes we use to engage the public about the City\u27s budget. The process includes regular online input as well as face-to-face, deliberative discussions. On occasions, random sample surveys also have been used. The public\u27s input has been helpful to City Hall in budget prioritization, and has even resulted, pursuant to residents\u27 recommendations, in raising taxes to preserve programs rather than eliminating them to balance the City\u27s budget. In an era of concern that the American public will not endorse tax increases, the recommendation was surprising. Our work to date indicates the public welcomes the invitation to participate in governance and responds positively to the opportunity to provide input and is willing to endorse policy options that have been thought to be unpopular by a majority of Americans

Photoinduced transient stark spectroscopy in organic semiconductors: a method for charge mobility determination in the picosecond regime.

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Structural and biophysical properties of a synthetic channel-forming peptide: designing a clinically relevant anion selective pore

The design, synthesis, modeling and in vitro testing of channel-forming peptides derived from the cys-loop superfamily of ligand-gated ion channels are part of an ongoing research focus. Over 300 different sequences have been prepared based on the M2 transmembrane segment of the spinal cord glycine receptor α-subunit. A number of these sequences are water-soluble monomers that readily insert into biological membranes where they undergo supramolecular assembly, yielding channels with a range of selectivities and conductances. Selection of a sequence for further modifications to yield an optimal lead compound came down to a few key biophysical properties: low solution concentrations that yield channel activity, greater ensemble conductance, and enhanced ion selectivity. The sequence NK[subscript]4-M2GlyR T19R, S22W (KKKKPARVGLGITTVLTMRTQW) addressed these criteria. The structure of this peptide has been analyzed by solution NMR as a monomer in detergent micelles, simulated as five-helix bundles in a membrane environment, modified by cysteine-scanning and studied for insertion efficiency in liposomes of selected lipid compositions. Taken together, these results define the structural and key biophysical properties of this sequence in a membrane. This model provides an initial scaffold from which rational substitutions can be proposed and tested to modulate anion selectivity. This article is part of a Special Issue entitled: Protein Folding in Membranes

Methods for Managing Human–Deer Conflicts in Urban, Suburban, and Exurban Areas

This monograph identifies challenges and benefits associated with many human–deer conflict mitigation actions as well as methods to monitor the response of deer populations to management actions. Deer exploit urban, suburban, and exurban areas where human populations provide anthropogenic attractants, either intentionally or inadvertently, which often leads to human–deer conflicts. Mitigating actions have varying degrees of efficacy and may not be effective or accepted in every situation. Wildlife and municipal managers must work together to seek methods to reduce attractants, mitigate conflicts, and perpetuate the conservation of wildlife species that adds to the appreciation of nature in our lives.https://digitalcommons.usu.edu/hwi_monographs/1001/thumbnail.jp