Finite-time lag projective synchronization of delayed fractional-order quaternion-valued neural networks with parameter uncertainties

This paper discusses a class issue of finite-time lag projective synchronization (FTLPS) of delayed fractional-order quaternion-valued neural networks (FOQVNNs) with parameter uncertainties, which is solved by a non-decomposition method. Firstly, a new delayed FOQVNNs model with uncertain parameters is designed. Secondly, two types of feedback controller and adaptive controller without sign functions are designed in the quaternion domain. Based on the Lyapunov analysis method, the non-decomposition method is applied to replace the decomposition method that requires complex calculations, combined with some quaternion inequality techniques, to accurately estimate the settling time of FTLPS. Finally, the correctness of the obtained theoretical results is testified by a numerical simulation example

Decitabine combined with arsenic trioxide inhibits proliferation and promotes apoptosis of acute myeloid leukemia cell lines

Objective To investigate the effects of decitabine (DAC) combined with arsenic trioxide (ATO) on proliferation and apoptosis of AML cells and its underlying molecular mechanism. Methods AML cell lines were treated with DAC and ATO alone or in combination. CCK8 was used to detect cell viability;Compusyn software was used to analyze the synergistic effects of the combination treatment;Flow cytometry was applied to determine the apoptosis and cell cycle distribution;Western blot was applied to detect the expressions of poly (ADP-ribose) polymerase (PARP), c-PARP, phosphatidylinositol 3-kinase (PI3K), p-PI3K, protein kinase B (Akt) and p-Akt. Results DAC and ATO alone inhibited AML cell proliferation in a concentration-dependent manner. The combination of the two drugs significantly inhibited cell proliferation, induced apoptosis and cycle arrest of AML cells (P＜0.05). Combination therapy reduced the phosphorylation level of PI3K and Akt (P＜0.05). Conclusions DAC combined with ATO may have anti-AML effect by inhibiting PI3K/Akt pathway, which provides new theoretical basis of DAC+ATO strategy for AML

The Up-regulation of Carbonic Anhydrase Genes of <i>Bacillus mucilaginosus</i> under Soluble Ca²⁺ Deficiency and the Heterologously Expressed Enzyme Promotes Calcite Dissolution

<div><p>Molecular mechanisms and gene regulation are of interest in the area of geomicrobiology in which the interaction between microbes and minerals is studied. This paper focuses on the regulation of the expression of carbonic anhydrase (CA) genes in <i>Bacillus mucilaginosus</i> and the effects of the expression product of the <i>B. mucilaginosus</i> CA gene in <i>Escherichia coli</i> on calcite weathering. Real-time fluorescent quantitative PCR (RT-qPCR) was used to explore the relationship between CA gene expression in <i>B. mucilaginosus</i> and promotion of calcite dissolution under condition of Ca²⁺ deficiency. The results showed that adding calcite to the medium, which lacks Ca²⁺, can up-regulate the expression of the bacterial CA genes to accelerate calcite dissolution for bacterial growth. CA genes from <i>B. mucilaginosus</i> were transferred into <i>E. coli</i> by cloning. We then employed crude enzyme extract from the resultant <i>E. coli</i> strain in calcite dissolution experiments. The enzyme extract promoted calcite dissolution. These findings provide direct evidence for the role of microbial CA on mineral weathering and mineral nutrition release.</p></div