Sustainable Energy Supplies in Developing Countries: Does National Governance Matter?

In this paper, we examine the impact of national governance quality on clean energy supplies in developing countries. We used a large sample of 103 developing countries over 21 years. We employ pooled ordinary least squares as the primary estimator. Additionally, we apply a Fixed Effect and the Two-Step System-Generalized Method of Moments to mitigate contemporaneity bias. Following prior studies, we construct national governance quality from the six World Governance Indicators. Consistent with our expectations, we find a positive and significant association between national governance quality and clean energy supplies. The results show that countries with high national governance quality are more likely to generate high amounts of clean energy than low-governed countries and to experience a high green economy. The results are also significant when the governance indicator is disaggregated into individual components. However, in a continental analysis, we found that the link between national governance quality and clean energy supplies is stronger in Africa than on other continents. Our results are robust to alternative measurements and econometric identification strategies

Sustainable Energy Supplies in Developing Countries: Does National Governance Matter?

In this paper, we examine the impact of national governance quality on clean energy supplies in developing countries. We used a large sample of 103 developing countries over 21 years. We employ pooled ordinary least squares as the primary estimator. Additionally, we apply a Fixed Effect and the Two-Step System-Generalized Method of Moments to mitigate contemporaneity bias. Following prior studies, we construct national governance quality from the six World Governance Indicators. Consistent with our expectations, we find a positive and significant association between national governance quality and clean energy supplies. The results show that countries with high national governance quality are more likely to generate high amounts of clean energy than low-governed countries and to experience a high green economy. The results are also significant when the governance indicator is disaggregated into individual components. However, in a continental analysis, we found that the link between national governance quality and clean energy supplies is stronger in Africa than on other continents. Our results are robust to alternative measurements and econometric identification strategies

Healthcare services efficiency and its intrinsic drivers in China: based on the three-stage super-efficiency SBM model

Abstract Background The purpose of this study is to examine the development of healthcare services efficiency in China since the reform of the healthcare system. By examining the development environment of healthcare services in China and examining the driving factors affecting the efficiency of healthcare services, we provide a reference for the future high-quality development of healthcare services in China. Methods A three-stage super-efficient slack-based measure (SBM) model with undesirable outputs was used to measure the efficiency of healthcae services in 31 Chinese provinces from 2009 to 2021, and a global Malmquist-Luenberger (GML) index was used to assess their spatiotemporal evolution characteristics and internal influencing mechanisms of healthcare services efficiency. Results The empirical results showed that the efficiency of China's healthcare services changed significantly from 2009–2014 and then remained stable. During the study period, the efficiency of healthcare services in the eastern region was higher than the national level, while it was lower in the western region. The results of the analysis of environmental factors indicated that an increase in population density reduced the redundancy of healthcare input resources and that economic development as well as an increase in government subsidies, contributed to an increase in the redundancy of healthcare input resources. The main contribution to the growth of healthcare sercices efficiency in China came from the technological innovation effect, and the growth was most significant in the western region. Conclusion From 2009 to 2021, the efficiency of national healthcare services generally showed a slow upward trend, and the efficiency of healthcare services varied widely among regions. Under the existing environmental constraints, relevant departments in each region should strengthen technological innovation in healthcare services, completely focus on the regional catch-up effect, and promote the balanced development of regional health

National debt management and business sustainability in Africa’s largest economy: A focus on the private sector

In many developing economies, high and increasing public debt profile constitutes an essential means of financial risk. An appropriate debt management is germane for survival of business and good international reputation though its effect on private sector credit mobilization had been seldomly investigated. This study seeks to know whether strategic debt management approach exacts a significant effect on the Nigerian private sector and Africa at large resulting to higher credit availability for sustainable enterprise establishment. The study used a time-series observation spanning from 1981–2021. The method of data analysis employed the unit root test for stationarity. Johansen cointegration and vector error correction approach. The result of the unit root test indicates the series were all stationary after first difference and thus were integrated of order1. The Johansen cointegration test support the existence of a cointegrating series between the private credit and its determinants. More empirical evidence from the study shows that proper debt management and increase revenue generation through net taxes on products accounted for 0.93 and 1.32% increase in private sector credit mobilization, while total external debt stock was responsible for a significant negative influence of 0.60% on private sector credit mobilization. The study recommends that the government should always be proactive in their strategic and innovative approach to debt management, revenue generation and sources of funds. This will help not only to avoid crowding out of the private sector but will enhance adequate credit mobilization for effective operations of the private sector

Genetic Regulation of GA Metabolism during Vernalization, Floral Bud Initiation and Development in Pak Choi (Brassica rapa ssp. chinensis Makino)

Pak choi (Brassica rapa ssp. chinensis Makino) is a representative seed vernalization vegetable and premature bolting in spring can cause significant economic loss. Thus, it is critical to elucidate the mechanism of molecular regulation of vernalization and floral bud initiation to prevent premature bolting. Gibberellin (GA) is the key plant hormone involved in regulating plant development. To gain a better understanding of GA metabolism in pak choi, the content of GA in pak choi was measured at different stages of plant development using enzyme-linked immunosorbent assay. The results showed that the GA content increased significantly after low-temperature treatment (4°C) and then decreased rapidly with vegetative growth. During floral bud initiation, the GA content increased rapidly until it peaked upon floral bud differentiation. To elucidate these changes in GA content, the expression of homologous genes encoding enzymes directly involved in GA metabolism were analyzed. The results showed that the changes in the expression of four genes involved in GA synthesis (Bra035120 encoding ent-kaurene synthase, Bra009868 encoding ent-kaurene oxidase, Bra015394 encoding ent-kaurenoic acid oxidase, and Bra013890 encoding GA20-oxidase) were correlated with the changes in GA content. In addition, by comparing the expression of genes involved in GA metabolism at different growth stages, seven differentially expressed genes (Bra005596, Bra009285, Bra022565, Bra008362, Bra033324, Bra010802, and Bra030500) were identified. The differential expression of these genes were directly correlated with changes in GA content, suggesting that these genes were directly related to vernalization, floral bud initiation and development. These results contribute to the understanding of the molecular mechanism of changes in GA content during different developmental phases in pak choi

Effect of early embryonic exposure to morphine on defects in the GABAergic system of day-old chicks

Embryonic morphine exposure (EME) leads to abnormal brain development and behavior in the offspring, and the functional alteration of gamma-aminobutyric acid (GABA) system is considered to be one of the important mechanisms. To mimic the problem of susceptibility of human gestational drug abuse on addictive drugs in offspring, we administered morphine exposure on days 5-8 and 13-16 of chicken embryo development and examined the functions of GABA neurons and their receptors in postnatal chicks by neuroelectrophysiology, immunohistochemistry and behavioral methods. We found that morphine exposure during embryonic stages 5-8 (MorphineE5-8) significantly reduced the incidence of spontaneous inhibitory postsynaptic potentiation (IPSP) and the induction of evoked IPSP and the mean amplitude of GABAA agonist muscimol-induced response in the intermediate medial interstitial (IMM) region, compared to naive controls or saline-exposed chicks. The results of immunocytochemistry further suggest that MorphineE5-8 decreased the synaptic density of GAD-expressing sites in the IMM, while increased the expression of the GABAA receptor subtype gamma 2 isoform. Behavioral results found that Morphine5-8 treatment de-inhibited morphine-induced psychomotor responses in postnatal chicks. Morphine exposure at embryonic stages 13-16 (MorphineE13-16) showed no significant changes in the above indicators compared to the saline group. Evidence suggests that early embryonic morphine exposure leads to defects in GABAergic function in the IMM, which in turn alters the responsiveness of postnatal chicks to addictive drugs. These results will help to understand the GABA mechanisms by which embryonic addictive drug exposure contributes to offspring susceptibility to addiction

Full-Spectrum Solar-to-Heat Conversion Membrane with Interfacial Plasmonic Heating Ability for High-Efficiency Desalination of Seawater

The current challenge in solar thermal utilization is how to effectively convert full-spectrum sunlight into directly available thermal energy for applications at high conversion efficiency. Herein, we report a novel strategy for the construction of large-area porous CuS/polyethylene (PE) hybrid membrane as a superior interfacial plasmonic photothermal material for high-efficiency solar thermal conversion to produce steam generation off seawater. The single-layer CuS/PE membrane materials have effective full-spectra sunlight absorption, excellent solar-to-heat conversion ability, low thermal conductivity, good hydrophilicity, and open micro/nanoscopic porosity for capillarity and self-floating, etc. Impressively, a single piece of porous CuS/PE membrane under one sun illumination can exhibit a superior conversion efficiency of 63.9% from sunlight to heat of seawater evaporation. Meanwhile, the plasmonic photothermal CuS/PE membrane can be recycled at least 20 times. Therefore, with the demonstrated convenient fabrication process, low cost, and high evaporation efficiency, the single-layer porous CuS/PE membrane materials offer great promise to convert sunlight into thermal energy for practical applications of steam generation

Single-cell analysis reveals insights into epithelial abnormalities in ovarian endometriosis

Summary: Ovarian endometriosis is characterized by the growth of endometrial tissue within the ovary, causing infertility and chronic pain. However, its pathophysiology remains unclear. Utilizing high-precision single-cell RNA sequencing, we profile the normal, eutopic, and ectopic endometrium from 34 individuals across proliferative and secretory phases. We observe an increased proportion of ciliated cells in both eutopic and ectopic endometrium, characterized by a diminished expression of estrogen sulfotransferase, which likely confers apoptosis resistance. After translocating to ectopic lesions, endometrial epithelium upregulates nicotinamide N-methyltransferase expression that inhibits apoptosis by promoting deacetylation and subsequent nuclear exclusion of transcription factor forkhead box protein O1, thereby leading to the downregulation of the apoptotic gene BIM. Moreover, epithelial cells in ectopic lesions elevate HLA class II complex expression, which stimulates CD4+ T cells and consequently contributes to chronic inflammation. Altogether, our study provides a comprehensive atlas of ovarian endometriosis and highlights potential therapeutic targets for modulating apoptosis and inflammation