Factors Affecting Public Engagement by Researchers: a Study on Behalf of a Consortium of Uk Public Research Funders

The "Factors affecting public engagement by researchers" project suggests that the embedding of public engagement in institutional cultures is best understood as a 'work in progress'. There are positive indications in the project outputs that public engagement is increasingly part of the landscape of higher education and research institutions, and that participation in and value placed on public engagement has increased in recent years. At the same time, the research suggests that researchers and institutions remain uncertain about systems of rewards for public engagement, within the context of a profession that is driven by research (and teaching). The project suggests that public engagement is more firmly embedded in the context of the arts, humanities and social sciences than it is among researchers in science, technology, engineering and mathematics. Wide-ranging research over a lengthy period shows that institutional change of this kind is highly challenging and that higher education institutions are known to be relatively slow to change. Within this context, the project indicates that, while recent and current strategies have been helpful, longer term effort -- perhaps targeted in particular domains -- is required

Changing Conceptions of Speaking in Tongues and Spirit Baptism Among Canadian Pentecostal Clergy

In 2014, a strong majority of clergy within the Pentecostal Assemblies of Canada (PAOC) agreed that speaking in tongues is the initial physical evidence of Spirit baptism, but less than half agreed that tongues speech is a necessary component of Spirit baptism. This represents a significant departure from a generation ago. Drawing on both quantitative and qualitative data, this article describes the specific nature of the transformation of Pentecostalism’s central theological and ritual component among PAOC clergy and presents two arguments. First, sociologically we argue that the changing views of PAOC clergy regarding the relationship of tongues speech to Spirit baptism are the result of their participation in the broader generic evangelical subculture, which promotes the adoption of a common evangelical religious identity and experience. Second, historically we argue that, rather than representing a simple capitulation to modern influences, this change, if even unintentionally, shows some similarity to both early American and Canadian Pentecostal views regarding Spirit baptism.

Instant Messenger Friends? Social Relationship Behavior Differences Between Two Countries

Canadian and U.S. respondents’ social behavior resulting from communication tools is examined.  Results suggest that Canadians are less likely to use social communication tools to develop new relationships

Hope, Optimism, and Affect as Predictors and Consequences of Expectancies: The Potential Moderating Roles of Perceived Control and Success

Hope and optimism may be differentially influential depending on the situational context. This study sought to (1) experimentally test whether hope and optimism differentially predict specific expectancies in controllable versus uncontrollable situations and (2) examine the relative impact of specific expectancies on affect when desired outcomes are (or are not) achieved. A 2 × 2 independent samples design was used to experimentally manipulate perceived control and situational outcome (i.e., success or failure). Online participants (N = 571) completed self-report measures of hope and optimism before being randomly assigned to one of four experimental conditions. Results showed that hope, but not optimism, predicted specific expectancies in the perceived control condition. Conversely, optimism, but not hope, predicted specific expectancies in the no perceived control condition. More optimistic specific expectancies of success predicted greater positive affect regardless of success or failure outcome

Pure iterative reconstruction improves image quality in computed tomography of the abdomen and pelvis acquired at substantially reduced radiation doses in patients with active Crohn disease

Objective: We assessed diagnostic accuracy and image quality of modified protocol (MP) computed tomography (CT) of the abdomen and pelvis reconstructed using pure iterative reconstruction (IR) in patients with Crohn disease (CD). Methods: Thirty-four consecutive patients with CD were referred with suspected extramural complications. Two contemporaneous CT datasets were acquired in all patients: standard protocol (SP) and MP. The MP and SP protocols were designed to impart radiation exposures of 10% to 20% and 80% to 90% of routine abdominopelvic CT, respectively. The MP images were reconstructed with model-based IR (MBIR) and adaptive statistical IR (ASIR). Results: The MP-CT and SP-CT dose length product were 88 (58) mGy.cm (1.27 [0.87] mSv) and 303 [204] mGy.cm (4.8 [2.99] mSv), respectively (P < 0.001). Median diagnostic acceptability, spatial resolution, and contrast resolution were significantly higher and subjective noise scores were significantly lower on SP-ASIR 40 compared with all MP datasets. There was perfect clinical agreement between MP-MBIR and SP-ASIR 40 images for detection of extramural complications. Conclusions: Modified protocol CT using pure IR is feasible for assessment of active CD

Hope and Optimism as Predictors of Academic Performance and Subjective Well-Being in College Students

Objective Snyder's (1994) hope and Scheier and Carver's (1985) optimism have been shown to independently predict academic performance and changes in subjective well-being. This study seeks to clarify their unique associations. Method An undergraduate class (N = 334, 59.6% female, 75.7% Caucasian, M = 19.89 years) was studied at two time points in a semester. Students predicted their expected grade in the course and completed measures of hope, optimism, and subjective well-being (i.e., positive affect, negative affect, and life satisfaction) the first week of classes. The final week of classes, students completed subjective well-being measures and final grades were obtained from the instructor. Results Path analysis showed that hope, but not optimism, predicted grade expectancy. Grade expectancy, in turn, predicted final grades, even after controlling for previous academic achievement. Hope did not directly predict final course grade, but had a significant indirect effect through grade expectancy. Path analysis showed that hope significantly predicted increases in positive affect and life satisfaction over the semester; whereas, optimism predicted decreases in negative affect. Conclusion These findings extend previous research demonstrating that hope and optimism, while conceptually similar, have differential longitudinal associations with academic performance and subjective well-being among college students. Implications for screening for at-risk college students and employing targeted interventions are discussed

Optimization of Potent Hepatitis C Virus NS3 Helicase Inhibitors Isolated from the Yellow Dyes Thioflavine S Primuline

A screen for hepatitis C virus (HCV) NS3 helicase inhibitors revealed that the commercial dye thioflavine S was the most potent inhibitor of NS3-catalyzed DNA and RNA unwinding in the 827-compound National Cancer Institute Mechanistic Set. Thioflavine S and the related dye primuline were separated here into their pure components, all of which were oligomers of substituted benzothiazoles. The most potent compound (P4), a benzothiazole tetramer, inhibited unwinding >50% at 2±1 μM, inhibited the subgenomic HCV replicon at 10 μM, and was not toxic at 100 μM. Because P4 also interacted with DNA, more specific analogs were synthesized from the abundant dimeric component of primuline. Some of the 29 analogs prepared retained ability to inhibit HCV helicase but did not appear to interact with DNA. The most potent of these specific helicase inhibitors (compound 17) was active against the replicon and inhibited the helicase more than 50% at 2.6±1 μM

The effect of vitamin K1 supplemention for 12 months on bone mineral density and indices of vitamin K status and bone turnover in adult Crohn s disease patients

peer-reviewedAdult patients with Crohn’s disease (CD), even those in remission, have been shown to have higher circulating under-g-carboxylated osteocalcin (ucOC) concentrations, a sensitive marker of vitamin K nutritional status(1), compared to age- and sex-matched healthy control subjects(2,3). Increased concentrations of ucOC in CD patients in these studies appear to be positively and negatively associated with the rate of bone turnover(3) and bone mineral density (BMD) at some sites(2), respectively. The aim of our study was to investigate whether supplementation with vitamin K1 (1000 mg/d) for 12 months had a positive effect on the rate of bone turnover and BMD in CD patients. We have previously shown that this level of supplementation maximally suppresses the degree of ucOC in CD patients(4).PUBLISHEDpeer-reviewe

Calcium phosphate particles stimulate interleukin-1β release from human vascular smooth muscle cells: A role for spleen tyrosine kinase and exosome release

Aims: Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspase-1 activation and secretion of mature interleukin-1β (IL-1β). Given the close association of small CaP particles with vascular smooth muscle cells (VSMCs) in atherosclerotic fibrous caps, we aimed to determine if CaP particles affected pro-inflammatory signalling in human VSMCs. Methods and results: Using ELISA to measure IL-1β release from VSMCs, we demonstrated that CaP particles stimulated IL-1β release from proliferating and senescent human VSMCs, but with substantially greater IL-1β release from senescent cells; this required caspase-1 activity but not LPS-priming of cells. Potential inflammasome agonists including ATP, nigericin and monosodium urate crystals did not stimulate IL-1β release from VSMCs. Western blot analysis demonstrated that CaP particles induced rapid activation of spleen tyrosine kinase (SYK) (increased phospho-Y525/526). The SYK inhibitor R406 reduced IL-1β release and caspase-1 activation in CaP particle-treated VSMCs, indicating that SYK activation occurs upstream of and is required for caspase-1 activation. In addition, IL-1β and caspase-1 colocalised in intracellular endosome-like vesicles and we detected IL-1β in exosomes isolated from VSMC media. Furthermore, CaP particle treatment stimulated exosome secretion by VSMCs in a SYK-dependent manner, while the exosome-release inhibitor spiroepoxide reduced IL-1β release. Conclusions: CaP particles stimulate SYK and caspase-1 activation in VSMCs, leading to the release of IL-1β, at least in part via exosomes. These novel findings in human VSMCs highlight the pro-inflammatory and procalcific potential of microcalcification