Exercise and the microbiota

The authors are supported in part by research grants from Science Foundation Ireland including a centre grant (Alimentary Pharmabiotic Centre; Grant Numbers SFI/12/RC/2273 and 12/RC/2273). Dr. Orla O’Sullivan is funded by a Starting Investigator Research Grant from Science Foundation Ireland (Grant number 13/SIRG/2160). Dr. Paul Cotter is funded by a Principal Investigator Award from Science Foundation Ireland P.D.C are supported by a SFI PI award (Grant number 11/PI/1137).peer-reviewedSedentary lifestyle is linked with poor health, most commonly obesity and associated disorders, the corollary being that exercise offers a preventive strategy. However, the scope of exercise biology extends well beyond energy expenditure and has emerged as a great ‘polypill’, which is safe, reliable and cost-effective not only in disease prevention but also treatment. Biological mechanisms by which exercise influences homeostasis are becoming clearer and involve multi-organ systemic adaptations. Most of the elements of a modern lifestyle influence the indigenous microbiota but few studies have explored the effect of increased physical activity. While dietary responses to exercise obscure the influence of exercise alone on gut microbiota, professional athletes operating at the extremes of performance provide informative data. We assessed the relationship between extreme levels of exercise, associated dietary habits and gut microbiota composition, and discuss potential mechanisms by which exercise may exert a direct or indirect influence on gut microbiota.The authors are supported in part by research grants from Science Foundation Ireland including a centre grant (Alimentary Pharmabiotic Centre; Grant Numbers SFI/12/RC/2273 and 12/RC/2273). Dr. Orla O’Sullivan is funded by a Starting Investigator Research Grant from Science Foundation Ireland (Grant number 13/SIRG/2160). Dr. Paul Cotter is funded by a Principal Investigator Award from Science Foundation Ireland P.D.C are supported by a SFI PI award (Grant number 11/PI/1137)

Targeting the Microbiota to Address Diet-Induced Obesity: A Time Dependent Challenge

peer-reviewedLinks between the gut microbiota and host metabolism have provided new perspectives on obesity. We previously showed that the link between the microbiota and fat deposition is age- and time-dependent subject to microbial adaptation to diet over time. We also demonstrated reduced weight gain in diet-induced obese (DIO) mice through manipulation of the gut microbiota with vancomycin or with the bacteriocin-producing probiotic Lactobacillus salivarius UCC118 (Bac+), with metabolic improvement achieved in DIO mice in receipt of vancomycin. However, two phases of weight gain were observed with effects most marked early in the intervention phase. Here, we compare the gut microbial populations at the early relative to the late stages of intervention using a high throughput sequencing-based analysis to understand the temporal relationship between the gut microbiota and obesity. This reveals several differences in microbiota composition over the intervening period. Vancomycin dramatically altered the gut microbiota composition, relative to controls, at the early stages of intervention after which time some recovery was evident. It was also revealed that Bac+ treatment initially resulted in the presence of significantly higher proportions of Peptococcaceae and significantly lower proportions of Rikenellaceae and Porphyromonadaceae relative to the gut microbiota of L. salivarius UCC118 bacteriocin negative (Bac-) administered controls. These differences were no longer evident at the later time. The results highlight the resilience of the gut microbiota and suggest that interventions may need to be monitored and continually adjusted to ensure sustained modification of the gut microbiota.The authors are supported in part by Teagasc, Science Foundation Ireland (in the form of a research centre grant to the Alimentary Pharmabiotic Centre and PI awards to PWOT and PC) and by Alimentary Health Ltd

Improving Patient Experience and Education by Leveraging Technology

It is estimated that 65% of the population are visual learners. With that in mind, a team of cardiac nurses in a large academic tertiary hospital developed a quality improvement project to hopefully improve patient engagement as well the patients’ perception that the nurses explained things in a manner that they could understand. Baseline patient survey scores for the question, “Nurses Explained Things In A Way That I Understand”, were under the 75thpercentile for a period of 9 months. A root cause analysis was conducted and it demonstrated numerous reasons for this score. Several countermeasures were instituted to include the use of I Pads for patient education. In conjunction with the hospital IT specialists, cardiac educational materials were developed and videos chosen for I Pad use. A daily KPI was established to track progress of their i Pad usage goal. Follow-up survey results demonstrated significant improvement post I Pad implementation to the question “Nurses Explained Things In A Way That I Understand”. Next steps include further education of nursing staff on educating patients in the use of I Pads as well as adding other cardiovascular educational materials

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Positive transfer as a function of the degree of inter-list stimulus similarity and initial list learning

The present study was designed to test the hypothesis that positive transfer is a function of the degree of inter-list stimulus similarity, and the degree of learning of an initial list. More specifically, the following hypotheses, derived from E. J. Gibson's theory of verbal learning, were tested: 1. Positive transfer is a function of inter-list stimulus similarity. A decrease of inter-list stimulus similarity will result in a decrease in the amount of positive transfer. 2. Less positive transfer will occur to a second list if practice of an initial list is continued after discrimination has been established among the stimulus items. The effect of the interaction between inter-list stimulus similarity and the degree of initial list learning was also assessed. Since the status of Gibson's theory did not enable the deduction of a hypothesis, the null hypothesis was tested. Sixty subjects learned an initial list of eleven stimulus forms paired with nonsense syllables of zero associative value. The subjects were required to learn each syllable so that they could spell it when the appropriate form was presented. Learning was by the method of right associates, and material was presented at the rate of two seconds per item, with a six second interval between trials. Thirty of the subjects learned this list to a criterion of one perfect recitation, and the other thirty subjects learned it to a criterion of five consecutive perfect recitations. When the criterion had been reached, the subjects were given a ten minute interval in which-to rate a series of thirty jokes. The subjects were then assigned to three groups. Each group consisted of ten subjects who had learned the initial list to a criterion of one perfect recitation, and ten who had learned it to five consecutive perfect recitations. As a transfer task, each group received a different list of paired associates, whose stimulus members were of either medium, low or zero similarity to those of the initial list. Each group learned this task to a criterion of one perfect recitation. Th8 main findings and conclusions of the study were as follows: 1. Positive transfer is a function of the degree of inter-list stimulus similarity. Significantly less transfer occurs to a list of zero similarity than to a list of medium similarity or to one of low similarity. There is no significant difference between the amount of transfer to a list of medium similarity and the amount of transfer to one of low similarity. This indicates that the relationship between positive transfer and inter-list stimulus similarity is indirect, whereas Gibson's theory indicates that the relationship should be linear. 2. Increasing the degree of initial list learning from one perfect recitation to five consecutive perfect recitations does not significantly decrease the amount of positive transfer. This was considered to be an inadequate test of Gibson's hypothesis, because the criterion of one perfect recitation did not allow discrimination to be established among the items. 3. There is no interaction between inter-list stimulus similarity and the degree of initial list learning.Arts, Faculty ofPsychology, Department ofGraduat

Moving Beyond “Agreeable” Texts and “Boring” Tasks: Pairing YAL and Critical Literacy in Teacher Education

This article considers the power of approaching young adult literature from a critical literacy perspective in teacher education and how that impacts emerging teachers’ ability to consider its role in their future teaching. Specifically, we explore how critical literacy – the exposure to a variety of texts, ways of approaching texts, and means of processing texts – can elevate pre-service teachers’ understanding of literature and the world around them, and thus, their ability to teach their future students from a critical literacy perspective. In this qualitative study of the teaching and learning of critical literacy in an Introduction to Adolescent Literature teacher education course, we illustrate how the pairing of literary theory and young adult literature can provide pre-service teachers the tools for questioning texts and larger societal issues with their future students. This study has practical implications for the field of teacher education in the way literature courses for pre-service teachers are designed and conceptualized

Delta weight gain over the eight week intervention period.

<p>(A) Bac⁺ intervention, when compared to Bac^- intervention, causes a significant reduction in weight gain in diet induced obese mice at weeks 2–4 (early intervention period) but this does not persist with time. (B) Vancomycin treatment results in a two phase reduction in weight gain in diet induced obese mice. In phase one (early; weeks 1–4) a significant reduction in weight gain relative to the initial start weight is observed. In the second phase, diet induced obese mice receiving vancomycin gain weight relative to the initial start weight but weight change continues to be significantly less than that in diet induced obese controls. Data represented as mean SEM n = 9–10 *p<0.05.</p