Investigating impacts of altered central metabolism on ovarian function

Mammalian reproduction is highly dependent on the ovary. Ovarian health is crucial for the health of the female and the offspring. Observations of the timing of puberty and ovarian function reveal a major role for the metabolic status of the female on reproductive function. Many metabolic signals such as leptin, insulin, and LPS influence ovarian function as they participate in metabolic stress. All of these signals cross pathways at PI3K. Obesity, the accumulation of excessive fat, is an international health concern of wide prevalence. It causes an increase in circulating leptin, insulin, and LPS, and is associated with numerous reproductive disorders. Here, we investigated the effects of increasing systemic leptin during gestation on the offspring, and observed that gestational hyperleptinemia can alter the ovarian capacity to metabolize toxicants later in the offspring\u27s life. Heat stress is a condition of increased core temperature, and it impedes the reproductive performance of production animals during summer, making it an increased threat to food security, climate change only worsening it. Heat stress causes increased circulating insulin and LPS. We heat stressed gilts cyclically after synchronizing their estrous cycles, and observed decreased phosphorylation of AKT and increased TLR4 abundance in their ovaries. This demonstrates that, during heat stress, ovarian TLR4 signaling is upregulated and that the ovary might be initiating a stress response as indicated by reduced AKT phosphorylatio

Using Rituals for Intervention Refinement

In this paper we propose a culture-based health promotion/disease prevention intervention model.  This model, which is family-based, incorporates a life course perspective, which involves the identification of individual developmental milestones, and incorporates aspects of culture that have been widely used across cultures to influence behavior and mark important developmental transitions. Central among those cultural traits is the ritual, or rite of passage, which, for millennia, has been used to teach the skills associated with developmental task mastery and move individuals, and their families, through life stages so that they reach certain developmental milestones. Family rituals, such as eating dinner together, can serve as powerful leverage points to support health behavior change, and serve as unique intervention delivery strategies that not only influence behavior, but further strengthen families.

Caffeine consumption among Zayed University students in Dubai, United Arab Emirates: A cross-sectional study

Background: Over the past decade, the global caffeine consumption rate has increased dramatically. Coffee and tea are among the common sources, but energy drinks are becoming an important contributor to total caffeine consumption. Recommendations for daily caffeine intake is not being followed due to the perceived benefits of caffeine which include mood improvement, concentration, social factors, and energy boosting. This study was important to add to the limited data about caffeine consumption in the Gulf region and mainly in the UAE. Objectives : The objectives were to determine the prevalence of caffeinated beverage consumption among university students and perceived benefits in addition to the estimation of daily caffeine consumption (mg/day). Design: Data was collected through a self-reported questionnaire from a total of 175 participants (129 females and 46 males) who were conveniently selected from different settings at Zayed University - Dubai. Usual Caffeine intake was calculated from all caffeine containing beverages.  Results: Eighty-six percent of the 175 participants, both males and females, at Zayed University-Dubai consumed caffeinated beverages with an average intake of 249.7±235.9 mg. The intake among the 150 caffeine consumers varied from 4.2 mg/day to 932.2 mg/day. Average intake of caffeine was not significantly different between genders (P=0.125). Thirty-five percent of the population consumed more than 400 mg/day of caffeine, with no statistical difference between males and females (P=0.202). Coffee was the most commonly consumed drink among both genders, followed by tea. Most perceived benefits of caffeine consumption were not significantly different except for the relationship between caffeine and improved exercise performance (P=0.018) and caffeine in relation to weight loss (P=0.001) among males. Conclusion: The prevalence of caffeine consumption at Zayed University was high among both males and females. Further research is necessary to estimate the total caffeine intake from all dietary sources, mainly the cultural foods and beverages, and to determine the relationship between accessibility to caffeine containing beverages and caffeine consumption among University student

Caffeine Consumption among Zayed University Students in Dubai, United Arab Emirates: A Cross-Sectional Study

Background: Over the past decade, the global caffeine consumption rate has increased dramatically. Coffee and tea are among the common sources, but energy drinks are becoming an important contributor to total caffeine consumption. Recommendations for daily caffeine intake is not being followed due to the perceived benefits of caffeine which include mood improvement, concentration, social factors, and energy boosting. This study was important to add to the limited data about caffeine consumption in the Gulf region and mainly in the UAE.Objectives: The objectives were to determine the prevalence of caffeinated beverage consumption among university students and perceived benefits in addition to the estimation of daily caffeine consumption (mg/day).Design: Data was collected through a self-reported questionnaire from a total of 175 participants (129 females and 46 males) who were conveniently selected from different settings at Zayed University - Dubai. Usual Caffeine intake was calculated from all caffeine containing beverages.  Results: Eighty-six percent of the 175 participants, both males and females, at Zayed University-Dubai consumed caffeinated beverages with an average intake of 249.7±235.9 mg. The intake among the 150 caffeine consumers varied from 4.2 mg/day to 932.2 mg/day. Average intake of caffeine was not significantly different between genders (P=0.125). Thirty-five percent of the population consumed more than 400 mg/day of caffeine, with no statistical difference between males and females (P=0.202). Coffee was the most commonly consumed drink among both genders, followed by tea. Most perceived benefits of caffeine consumption were not significantly different except for the relationship between caffeine and improved exercise performance (P=0.018) and caffeine in relation to weight loss (P=0.001) among males.Conclusion: The prevalence of caffeine consumption at Zayed University was high among both males and females. Further research is necessary to estimate the total caffeine intake from all dietary sources, mainly the cultural foods and beverages, and to determine the relationship between accessibility to caffeine containing beverages and caffeine consumption among University student

Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents

Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R(2) = 0.13, β = -1.7; p = 0.006; R(2) = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R(2) = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents

Left Main Coronary Artery Interventions

The management of left main coronary artery (LMCA) disease has evolved over the past two decades. Historically, coronary artery bypass grafting (CABG) surgery has been the gold standard for the treatment of LMCA disease. However, with the advancements in percutaneous coronary interventions (PCIs) and stent technology, PCI in select patients has achieved comparable outcomes to CABG. As such, this has led to changes in the American College of Cardiology and European Society of Cardiology guidelines, which recommend that PCI might be an alternative to CABG in select patients. In this review article, we describe the historical perspective and early experience with coronary interventions of LMCA disease, landmark clinical trials and their effect on guidelines, and the role of intravascular imaging in the management of LMCA lesions

Physical activity and FTO genotype by physical activity interactive influences on obesity

Background: Although the effect of the fat mass and obesity-associated (FTO) gene on adiposity is well established, there is a lack of evidence whether physical activity (PA) modifies the effect of FTO variants on obesity in Latino populations. Therefore, the purpose of this study was to examine PA influences and interactive effects between FTO variants and PA on measures of adiposity in Latinos. Results: After controlling for age and sex, participants who did not engage in regular PA exhibited higher BMI, fat mass, HC, and WC with statistical significance (P \u3c 0.001). Although significant associations between the three FTO genotypes and adiposity measures were found, none of the FTO genotype by PA interaction assessments revealed nominally significant associations. However, several of such interactive influences exhibited considerable trend towards association. Conclusions: These data suggest that adiposity measures are associated with PA and FTO variants in Latinos, but the impact of their interactive influences on these obesity measures appear to be minimal. Future studies with large sample sizes may help to determine whether individuals with specific FTO variants exhibit differential responses to PA interventions

Dual Antiplatelet Regimens for Transcatheter Aortic Valve Replacement and Corresponding Cardiac CT Evaluation of the Leaflets: Single-center Experience

Background: Transcatheter aortic valve replacement (TAVR) is a globally established therapy. However, there is significant variability in the antithrombotic management post-procedure. The data on antiplatetet and direct antithrombin agents suggest antiplatelet agents suffice. The degree of leaflet thickening on cardiac CT and the clinical implications of this finding remain poorly understood. Here, the authors aim to examine a low-risk cohort treated with dual antiplatelet therapy and the corresponding cardiac CT and clinical findings. Methods: This is a descriptive single center study examining patients who received dual antiplatelet therapy post-TAVR from 2017 to 2019. Patients underwent clinical, echocardiographic and cardiac CT follow up. Signs and symptoms of ischemic stroke, valve function, gradient, and cardiac CT findings of hypo-attenuated leaflet thickening and reduced leaflet mobility were recorded for all those who completed 6 months of follow-up. The study was registered and approved by the Ethics Committee. Results: A total of 116 patients were included. Hypo-attenuated leaflet thickening was detected in 11 patients. Only one had accompanying reduced leaflet mobility and an increase in gradient. This patient did not have any evidence of stroke or valve dysfunction. After switching to rivaroxaban, the gradient improved and a repeat cardiac CT demonstrated resolution of the leaflet thickening. Conclusion: This study illustrates the utility of cardiac CT in detecting leaflet thickening and restricted mobility post-TAVR in low-risk individuals treated with dual antiplatelet therapy. However, its role in guiding antithrombotic regimens cannot be ascertained from this study and additional larger scale studies comparing different regimens in both symptomatic and asymptomatic patients are necessary. Trial Registration: N/A