Job searching with a history of drugs and crime

This article explores the experiences and aspirations of offenders with histories of substance misuse in job searching. The analysis is based upon qualitative data from a localised study of 27 men and two women who were undertaking community-based court orders in Scotland. Their perspectives on job searching, job-readiness and aspirations for sustained employment including the role of self-employment are presented. The article concludes that with adequate support, greater tolerance and flexibility by employers and job searchers could contribute to reducing the vicious cycle of suspicion and dishonesty. Policy action needs to be sustained and possibly augmented to include enterprise training

Visual mate preference evolution during butterfly speciation is linked to neural processing genes

Abstract: Many animal species remain separate not because their individuals fail to produce viable hybrids but because they “choose” not to mate. However, we still know very little of the genetic mechanisms underlying changes in these mate preference behaviours. Heliconius butterflies display bright warning patterns, which they also use to recognize conspecifics. Here, we couple QTL for divergence in visual preference behaviours with population genomic and gene expression analyses of neural tissue (central brain, optic lobes and ommatidia) across development in two sympatric Heliconius species. Within a region containing 200 genes, we identify five genes that are strongly associated with divergent visual preferences. Three of these have previously been implicated in key components of neural signalling (specifically an ionotropic glutamate receptor and two regucalcins), and overall our candidates suggest shifts in behaviour involve changes in visual integration or processing. This would allow preference evolution without altering perception of the wider environment

Melanin as a target for melanoma chemotherapy: Pro-oxidant effect of oxygen and metals on melanoma viability

Melanoma cells have a poor ability to mediate oxidative stress, which may be attributed to constitutive abnormalities in their melanosomes. We hypothesize that disorganization of the melanosomes will allow chemical targeting of the melanin within. Chemical studies show that under oxidative conditions, synthetic melanins demonstrate increased metal affinity and a susceptibility to redox cycling with oxygen to form reactive oxygen species. The electron paramagnetic resonance (EPR)-active 5,5'-dimethyl-pyrollidine N-oxide spin adduct was used to show that binding of divalent Zn or Cu to melanin induces a pro-oxidant response under oxygen, generating superoxide and hydroxyl radicals. A similar pro-oxidant behaviour is seen in melanoma cell lines under external peroxide stress. Melanoma cultures grown under 95% O-2/5% CO2 atmospheres show markedly reduced viability as compared with normal melanocytes. Cu- and Zn-dithiocarbamate complexes, which induce passive uptake of the metal ions into cells, show significant antimelanoma activity. The antimelanoma effect of metal- and oxygen-induced stress appears additive rather than synergistic; both treatments are shown to be significantly less toxic to melanocytes

Corn response to nitrogen is influenced by soil texture and weather

Citation: Tremblay, Nicolas, Yacine M. Bouroubi, Carl Bélec, Robert William Mullen, Newell R. Kitchen, Wade E. Thomason, Steve Ebelhar, et al. “Corn Response to Nitrogen Is Influenced by Soil Texture and Weather.” Agronomy Journal 104, no. 6 (2012): 1658–71. https://doi.org/10.2134/agronj2012.0184.Soil properties and weather conditions are known to affect soil nitrogen (N) availability and plant N uptake. However, studies examining N response as affected by soil and weather sometimes give conflicting results. Meta-analysis is a statistical method for estimating treatment effects in a series of experiments to explain the sources of heterogeneity. In this study, the technique was used to examine the influence of soil and weather parameters on N responses of corn (Zea mays L.) across 51 studies involving the same N rate treatments which were carried out in a diversity of North American locations between 2006 and 2009. Results showed that corn response to added N was significantly greater in fine-textured soils than in medium-textured soils. Abundant and well-distributed rainfall and, to a lesser extent, accumulated corn heat units enhanced N response. Corn yields increased by a factor of 1.6 (over the unfertilized control) in medium-textured soils and 2.7 in fine-textured soils at high N rates. Subgroup analyses were performed on the fine-textured soil class based on weather parameters. Rainfall patterns had an important effect on N response in this soil texture class, with yields being increased 4.5-fold by in-season N fertilization under conditions of “abundant and well-distributed rainfall.” These findings could be useful for developing N fertilization algorithms that would allow for N application at optimal rates taking into account rainfall pattern and soil texture, which would lead to improved crop profitability and reduced environmental impacts