91 research outputs found

    My Memoirs

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    H. R. H. Sardar Shah Wali, the surviving uncle of His Majesty King Mohammed Zahir Shah of Afghanistan, was born in Debra Dun (India) in 1888. He studied Persian (Dari), Pashto, English and Urdu privately under the guidance of competent tutors. In 1901, the Sardar returned to his motherland with all the members of his family, and was warmly received at Kabul by Amir Abdur Rahman, ruler of Afghanistan. Sardar Shah Wali continued his studies until 1906 with emphasis on military science, and subsequently played a most important part in public affairs and in shaping the destinies of his homeland. Since his political and military knowledge fitted him for a military post, he was appointed the Officer of the Royal Bodyguard. In addition to this important post, he worked as Aid-de-Camp to His Majesty Amir Habibullah Khan.https://digitalcommons.unomaha.edu/ascdigitizedbooks/1017/thumbnail.jp

    LEARNING ORIENTATION AND PERFORMANCE: THE INTERACTION EFFECT OF ENTREPRENEURIAL ORIENTATION

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    The current study examines the impact of learningorientation (LO) on organizational performance and also themoderating role of entrepreneurial orientation (EO) on therelationship between LO and organizational performance amongthe small and medium enterprises (SMEs) in Pakistan. Thisquestionnaire survey was conducted among 213 managers/ ownersof manufacturing SMEs. Previous studies on LO in combinationwith EO have been conducted in large organizations in developedeconomies. Studying the relationship between LO and performanceand moderated by EO in manufacturing SMEs in a developingeconomy like Pakistan, this research attempts to fill this gap. Thefindings reveal that there exist a positive relationship between LOand organizational performance. The findings also demonstratethat the effects of LO on organizational performance are positivelymoderated by EO. The paper also includes research implicationsand possible future directions

    Food Habits and Helminth Parasites of Skittering Frog (Euphlyctis cyanophlyctis) in the Lower Dir, Pakistan

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    A total of 30 specimens of Skittering frog (Euphlyctis cyanophlyctis),(Anura: Dicroglossidae) were captured from seven selected localities inthe Dir Lower, Khyber Pakhtunkhwa province of Pakistan from Aprilto August 2016. They were euthanized with the help of Chloroform(CHcl3) solution. The biometry of each specimen was measured, thendissected to examine for helminth parasites and foodstuff. All helminths were isolated, washed with normal saline at room temperature,and then preserved in 70% GL ethyl alcohol. Later on, the parasiteswere classified and studied under the electric compound microscope. Ina total of 30 specimens, 17(56.66%) were found infected with 62 helminths parasites belongs to four different species. Among four species,one was Cestodes Nematotaenia dispar species and remaining threewere Nematodes i.e. Cosmocerca species, Cosmocercoides (Raillietnema species) and Strongyloides species. Cosmocerca with a percentageof 56.45% was the most dominant. In the total of 30 specimens’ alimentary canal, 10 were found empty, containing nothing while in remaining20 were full of 9 types of food materials which included insects i.e.Ants, Beetles, Wasps, Spiders, Mosquito larvae and cockroaches, andnon-living things like stone pebbles and mollusks shells. Among the serial, flies and snails were in the lowest prevalence and ants were recorded the most important component of the frog diet. Among the insects,ants have occurred in higher prevalence 44.50% and flies 1.15% withthe lowest prevalence. The results emphasize the significance of furtherexpected studies in the Dir Lower to get a good understanding of thehelminth parasites with the ecological relations of their hosts

    Perceived corporate social responsibility and pro-environmental behaviour: Insights from business schools of Peshawar, Pakistan

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    Corporate Social Responsibility (CSR) and environmental sustainability have become urgent concerns for contemporary businesses. This study focuses on the interplay between corporate social responsibility perceptions and pro-environmental behaviour (PEB) in response to experts’ call for research on the micro-foundations of corporate social responsibility. In addition, it reveals the mechanism underpinning how perceived CSR shapes pro-environmental behaviour in an understudied developing context. Empirically, a qualitative multiple-case research design is utilised by selecting three business schools from Peshawar, Pakistan. Fourteen semi-structured interviews were conducted with senior management and faculty to collect data. Besides primary data, a qualitative documentary review is used to enhance the research. Data analysis is done through the thematic network technique. Plantation, cleanliness, waste reduction, and energy conservation are the environmental aspects of CSR as regarded by employees. In addition, perceived CSR shapes pro-environmental behaviour via environmental knowledge and awareness, eco-civic sense, environmental values, personality traits, religious perspective, and perceived organisational support for the environment. This study provides original additions to the CSR literature by suggesting eco-civic sensibility and religious perspective as new CSR drivers for pro-environmental conduct. Incorporating stakeholder salience into the context of the present study also advances CSR research. The findings are also valuable for management to make the CSR agenda of business schools more strategic, comprehensive, and centred on the priorities of salient stakeholders

    Fuzzy adaptive teaching learning-based optimization for solving unconstrained numerical optimization problems

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    Teaching learning-based optimization is one of the widely accepted metaheuristic algorithms inspired by teaching and learning within classrooms. It has successfully addressed several real-world optimization problems, but it may still be trapped in local optima and may suffer from the problem of premature convergence in the case of solving some challenging optimization problems. To overcome these drawbacks and to achieve an appropriate percentage of exploitation and exploration, this study presents a new modified teaching learning-based optimization algorithm called the fuzzy adaptive teaching learning-based optimization algorithm. The proposed fuzzy adaptive teaching learning-based optimization algorithm uses three measures from the search space, namely, quality measure, diversification measure, and intensification measure. As the 50-50 probabilities for exploitation and exploration in the basic teaching learning-based optimization algorithm may be counterproductive, the Mamdani-type fuzzy inference system of the new algorithm takes these measures as a crisp inputs and generates selection as crisp output to choose either exploitation or exploration based on the current search requirement. This fuzzy-based adaptive selection helps to adequately balance global search or exploration and local search or exploitation operations during the search process as these operations are intrinsically dynamic. The performance of the fuzzy adaptive teaching learning-based optimization is evaluated against other metaheuristic algorithms including basic teaching learning-based optimization on 23 unconstrained global test functions. Moreover, adaptive teaching learning-based optimization is used to search for near-optimal values for the four parameters of the COCOMO II model, which are then tested for validity on a software project of NASA. Analysis and comparison of the obtained results indicate the efficiency and competitiveness of the proposed algorithm in addressing unconstrained continuous optimization tasks

    Toxicity assessment of Cedrus deodara oil compared to carbosulfan for Tenebrio molitor (Coleoptera: Tenebrionidae) adults

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    Specific compounds extracted from plants can control insect pests. The objective of this study was to evaluate the toxicity of deodar oil (phytopesticide) to adult mealworms Tenebrio molitor (Coleoptera: Tenebrionidae) compared with carbosulfan (synthetic insecticide), which exibits cholinesterase (ChE), glutamic pyruvic transaminase (GPT), and glutamic oxaloacetic transaminase (GOT) activities. The insecticides were applied through feeding, and the LC50 (lethal concentration) was calculated using the Finney method. The LC50 of deodar oil was higher than that of carbosulfan. The doses of both deodar oil and carbosulfan inhibited the ChE activity (p > 0.05) and enhanced the GPT and GOT activities (p < 0.05) in mealworm adults. Alterations in the activity of these biomarkers indicated that deodar oil could effectively control adult mealworms, being an environmentally low-impact method that can replace the use of chemical products

    Substantial and sustained reduction in under-5 mortality, diarrhea, and pneumonia in Oshikhandass, Pakistan : Evidence from two longitudinal cohort studies 15 years apart

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    Funding Information: Study 1 was funded through the Applied Diarrheal Disease Research Program at Harvard Institute for International Development with a grant from USAID (Project 936–5952, Cooperative Agreement # DPE-5952-A-00-5073-00), and the Aga Khan Health Service, Northern Areas and Chitral, Pakistan. Study 2 was funded by the Pakistan US S&T Cooperative Agreement between the Pakistan Higher Education Commission (HEC) (No.4–421/PAK-US/HEC/2010/955, grant to the Karakoram International University) and US National Academies of Science (Grant Number PGA-P211012 from NAS to the Fogarty International Center). The funding bodies had no role in the design of the study, data collection, analysis, interpretation, or writing of the manuscript. Publisher Copyright: © 2020 The Author(s).Peer reviewedPublisher PD

    Global Retinoblastoma Presentation and Analysis by National Income Level.

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    Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs

    Global Retinoblastoma Presentation and Analysis by National Income Level

    Get PDF
    Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- A nd middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs

    Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

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    Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10&nbsp;years; 78.2% included were male with a median age of 37&nbsp;years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020
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