ReferralWeb--a resource location system guided by personal relations

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.Includes bibliographical references (p. 47-[48]).by Mehul A. ShahM.Eng

DEVELOPMENT AND VALIDATION OF A HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY FOR THE DETERMINATION OF TERBUTALINE SULFATE, BROMHEXINE HYDROCHLORIDE, AND ETOPHYLLINE IN PHARMACEUTICAL DOSAGE FORM

Objective: The study aimed to development and validation of simple, precise, and reliable high-performance thin-layer chromatography (HPTLC) for the determination of terbutaline sulfate (TBS), bromhexine hydrochloride (BRH), and etophylline (ETP) in pharmaceutical dosage form. Methods: A simple, precise, rapid, and accurate HPTLC method was developed for the estimation of TBS, BRH, and ETP in pharmaceutical dosage form. Pre-coated silica gel G60 F254 aluminum sheet (10 cm2×10 cm2 and thickness 0.2 mm) was used as stationary phase while mobile phase consisting of benzene: methanol:glacial acetic acid 8:0.5:1.5 v/v/v detection at 275 nm. The present method had validated according to ICH guidelines. Results: Migration distance found 80 mm at 275 nm. The retention factor found to be 0.24, 0.57, and 0.68, respectively. The detector response was linear in the concentration range of 60–210 ng/band, 2400–8400 ng/band, and 96–336 ng/band, respectively. The linear regression equation being Y=32.20x−562.9, Y=11.79x−1711, and Y=1.756x−5636, respectively. The limit of detection for TBS 0.677 μg, for BRH 8.123 μg, and for ETP 57.915 μg and limit of quantification to be 2.053, 24.617, and 175.5 μg, respectively, were found. The developed method validated by ICH guideline, i.e., accuracy, precision, robustness, specificity, and system suitability. Conclusion: In this study, we had developed a simple, fast, and reliable HPTLC method for the determination of TBS, BRH, and ETP in pharmaceutical dosage form

Somatization and health seeking behavior

Background:Somatization is the state of being symptomatic which is not explained medically associated with psychological distress and health-seeking behavior and is present in at least 10% to 15% in OPD.Methods:50 patients with long standing history of MUS were evaluated by using modified Bradford inventory.Results: Somatization was most common in younger age, female and lower socio-economical class. Feeling of weakness or lack of energy much of the time in both male and female respectively 94.7% and 96.7% are the most common symptomatic presentation in Somatization during last 2 years, although there were symptomatic differences in males and females. Severity of symptoms was higher among females. 13% of female pts had undergone hysterectomy due to persistent gynecological problems during course of illness. 82% pts had illness of more than 2 years. The mean duration of illness at the time of assessment was 6.8 years. Most of the patients had visited to multiple consultants and underwent many costly diagnostic procedures for their symptoms .Most of the patients after multiple investigations and consultations were not ready to accept psychological origin of their physical illness and continued to see next practitioner as they remained dissatisfied and distressed. One or more physical illness is the common explanation by physicians. Patients presented with somatization has an another diagnosis in significant cases like Major depressive disorder, anxiety disorder, alcohol use disorder.Conclusion:Somatization was common among female, but it was not uncommon in male. Patient suffering from somatization disorder has very high rate of health care utilization and they perceived themselves as severely ill and were willing to undergo multiple hospitalizations, diagnostic studies, and operations, remained dissatisfied. Need to strengthened consultation liaison between physician and psychiatrist.

One year observational study of stillbirths in a referral hospital of Saurashtra region

Background: Stillbirths constitute a major part of perinatal death, and India ranks first in absolute number of stillbirths. The causes of stillbirth differ in different parts of the world and are affected by fetomaternal factors and type of antenatal and intrapartum care. The objective of this study was to evaluate the stillbirth rate as well as the aetiology and risk factors for stillbirths in our institute.Methods: All stillbirths delivered at or above 28 weeks of gestation or weighing more than 1000 gms in P. D. U. Medical College and Hospital, Rajkot during study period of 1 year were enrolled in the study. The stillbirth rate of the institute was studied. Socio-demographic, maternal and fetal factors of stillbirth cases were analysed.Results: Stillbirth rate of our institute was 41.63 per 1000 births. 70% cases belonged to rural region and 48% cases were referred to our hospital from other institutes. Stillbirth was found more in multigravida women with 67.2% cases. 57.01% stillborn babies were males, 34.71% of stillborns had extremely low birth weight and were pre-term. 54.78% stillborns were macerated. In 24.8% cases, aetiology of stillbirth was unknown. Antepartum haemorrhage contributed 19% cases, asphyxia -16.8% cases and pre-eclampsia-12.1% cases of stillbirth in our study.Conclusions: Proper screening and antenatal and intrapartum supervision and timely referral to the tertiary care centre can play an important role in decreasing the rate of stillbirths.

Identification of chalcone derivatives as putative non-steroidal aromatase inhibitors potentially useful against breast cancer by molecular docking and ADME prediction

Aromatase is an influential target to overcome estrogen receptor positive breast cancer, as the enzyme is responsible for conversion of androstenedione to estrone, a promising drug target for therapeutic management of breast cancer. Chalcones are prominent biosynthetic compounds and parent candidate for the synthesis of heterocycles with diversified biological activities. The prime objective of the present study is to evaluate the binding interaction of 2-hydroxyphenyl- prop-2-en-1-one (1A-1X), 2-hydroxy-4-methoxyphenyl- prop-2-en-1-one (3A-3X), 2,4-dihydroxyphenyl- prop-2-en-1-one (9A-9X) and 1-hydroxynaphthalen-2-yl-prop-2-en-1-one (5A-5X) derivatives with aromatase enzyme by molecular docking study and also check their ADME properties by maestro suit. The designed chalcones derivatives have been docked against our target protein with PDB id 3S7S retrieved from the protein data bank, whereas exemestane has been taken as the positive control. As docking data revealed that docking score of 1K, 1U, 1B 3K 3N, 5K, 5U, 9S, 9K, 9N and 9F compounds found less than exemestane and all of these compounds with appropriate ADME properties have proven their excellent absorption as well as solubility characteristics. The present findings provided valuable information about binding interactions of chalcones derivatives to the active site of aromatase. These compounds may serve as potential lead compound for developing new aromatase inhibitors in breast cancer treatment

Identification of chalcone derivatives as putative non-steroidal aromatase inhibitors potentially useful against breast cancer by molecular docking and ADME prediction

283-293Aromatase is an influential target to overcome estrogen receptor positive breast cancer, as the enzyme is responsible for conversion of androstenedione to estrone, a promising drug target for therapeutic management of breast cancer. Chalcones are prominent biosynthetic compounds and parent candidate for the synthesis of heterocycles with diversified biological activities. The prime objective of the present study is to evaluate the binding interaction of 2-hydroxyphenyl- prop-2-en-1-one (1A-1X), 2-hydroxy-4-methoxyphenyl- prop-2-en-1-one (3A-3X), 2,4-dihydroxyphenyl- prop-2-en-1-one (9A-9X) and 1-hydroxynaphthalen-2-yl-prop-2-en-1-one (5A-5X) derivatives with aromatase enzyme by molecular docking study and also check their ADME properties by maestro suit. The designed chalcones derivatives have been docked against our target protein with PDB id 3S7S retrieved from the protein data bank, whereas exemestane has been taken as the positive control. As docking data revealed that docking score of 1K, 1U, 1B 3K 3N, 5K, 5U, 9S, 9K, 9N and 9F compounds found less than exemestane and all of these compounds with appropriate ADME properties have proven their excellent absorption as well as solubility characteristics. The present findings provided valuable information about binding interactions of chalcones derivatives to the active site of aromatase. These compounds may serve as potential lead compound for developing new aromatase inhibitors in breast cancer treatment

The relationship between emotional intelligence and academic achievement in medical undergraduate

Background: In today’s era of technology, intelligence and success are not viewed the same way they were before. New theories of intelligence have been introduced and are gradually replacing the traditional theory. Academic achievement is based on creativity, emotions, and interpersonal skills. Methods: The aim of this study was to see whether there is a relationship between emotional intelligence and academic success. Study was done on 1st MBBS students of Govt. Medical College, Bhavnagar. The sample size was 75 students (boys and girls). The emotional intelligence questionnaire from Institute for Health and Human Potential was given to the students, Depending on the EQ score we divided the students in to five groups and compared with their academic performance. Results: Study showed inverse relationship between emotional intelligence and academic achievement.Conclusion: There is a negative relation among emotional intelligence and academic achievement of the participants