Design framework:redesign and new multi-user and testing support

The use of models to conceptualize systems is an important part of the process of building Cyber Physical Systems. While designing such systems, which are in general a multi-disciplinary activity, multiple designers are involved in the design decisions. Those decisions most likely are not captured and eventually forgotten after a period. The Design Framework is a visual modeling tool that aims to help architects and designers to documents the design rationales besides the design artifacts. It also helps them to collaborate to design a system together in a multidisciplinary environment. The Design Framework is at the level of a good prototype, but it is not ready for operational application by end-users in industry. One of the main issues with the Design Framework system is a sub-optimal code structure due to the lack of proper design and development approach. The assignment therefore is to reverse engineer the current design of the Design Framework and to come up with a new design. In order to maintain a system in use, presence of a test framework is necessary. Since the Design Framework is used in a multi-disciplinary environment, an improvement in the multi-user support of the system is also needed. In the first part of this report, the redesign of the Design Framework is discussed. To redesign the Design Frame-work, a number of refactoring techniques are applied. As a result, the code complexity is reduced, therefore the maintenance is increased. The second part of the assignment includes multi-user support and testability. The Design Framework manages the changes to design descriptions and maintains the history of the design artifacts. In this respect, it operates similar to version control systems. In the multi-user part of this report, the version controlling aspect of the Design Framework is described and synchronization of data for multi-user is elaborated. Finally some multi-user features are improved and developed. In the testability part of this report, the test support is described. A set of unit tests and end-to-end tests including the test for multi-user support is implemented. Provided test sets and the approaches used to setup test environment makes the Design Framework more stable and maintainable

Saliva Secretion and Efficacy of Helicobacter Pylori Eradication in Peptic Ulcer Patients

Objective: It has been noted that the presence of Helicobacter pylori (H. pylori)in the oral cavity may affect the outcome of eradication therapy. This condition is associated with the recurrence of gastric infection. The optimum secretion of salivapromotes oral health consequently influencing H. pylori eradication. The purpose of this study was to investigate the relation between salivary secretion and the efficacy of H. pylori eradication from the stomach.Materials and Methods: Forty five patients with gastric H. pylori infection were enrolled in this study. Diagnosis of H. pylori infection was confirmed by endoscopy,biopsy, urease test and histological examination. Salivary secretion of all participants was determined under standard condition before the beginning of antibacterial treatment. Then the patients were treated with a 14-day course anti-H. pylori regimen consisting of amoxicillin, omeprazole, metronidazole and bismuth. The efficacy of eradication therapy was evaluated 4 weeks after the end of the treatment course. Mann-Whitney U test was used to analyze the variables.Results: The median of salivary secretion among successful and unsuccessful H. pylori eradication groups was 0.48 ml/min and 0.24 ml/min, respectively (p=0.005).Conclusion: Although the type of drug regimens is challenging, the efficacy of H. pylori eradication from the stomach might be reduced by lower salivary secretion

Development of Portable Air Conditioning System Using Peltier and Seebeck Effect

The society bustle factor in this day and age, most people want to find equipment that is often used in everyday life in a small and light weight design. The purpose of this project is to develop portable air conditioning system without using any gas. The system used thermoelectric heat pump as main device for producing cool air known as Peltier Effect. The generating system theoretically can recycle the heat loss to produce additional electricity for other usage. The efficacy of this system tested using two types of experimental using Peltier and Seebeck Effect. Both experimental are conducted using 3 specific volumes; 1) 1000cm3; 2) 4000cm3; and 3) 9000cm3. As a result, temperature for heating and cooling systems achieve around 16 – 40 degree Celcius (oC) while the voltage generated around 12V in 30 minutes

Association of human platelet alloantigens encoding gene polymorphisms with the risk of Coronary artery disease in Iranian patients

Background: Coronary artery disease (CAD) is characterized by narrowing/ blockade of coronary arteries that is mainly caused by atherosclerotic plaques. Considering the involvement of platelet abnormalities, such as defective aggregation and adhesion, in the cardiovascular-related disorders, genetic variations in human platelet alloantigens (HPA) have been implicated in the CAD susceptibility. Herein, we intended to determine the association of HPA-1 to -6, -9, and -15 biallelic polymorphisms with CAD in an Iranian population. Methods: In this retrospective case�control study, 200 CAD subjects and 100 matched healthy individuals were enrolled. DNA samples were isolated from peripheral blood samples and genotyping of HPA polymorphisms was accomplished using polymerase chain reaction-sequence-specific primers. Results: The alleles and genotypes of studied HPA polymorphisms were equally distributed among cases and controls and therefore no statistically significant differences were detected. Univariate analysis identified no association of combined haplotypes with CAD risk. However, multivariate analysis showed a positive association of the� HPA1b/2a/3b haplotype with CAD after adjustment for some covariates (including BMI, TG, LDL, FBS and blood pressure) that conferred a CAD susceptibility haplotype (P = 0.015; OR = 2.792; 95 CI 1.45�8.59). Conclusions: Although alleles, genotypes, and haplotypes of HPA polymorphisms were not associated with CAD risk, HPA1b/2a/3b haplotype was found to be a dependent disease risk haplotype in Iranian population after correcting for confounding factors. © 2021, The Author(s)

Systematic investigation of the elastic proton-deuteron differential cross section at intermediate energies

To investigate the importance of three-nucleon forces (3NF) systematically over a broad range of intermediate energies, the differential cross sections of elastic proton-deuteron scattering have been measured at proton bombarding energies of 108, 120, 135, 150, 170 and 190 MeV at center-of-mass angles between $30^\circ$ and $170^\circ$. Comparisons with Faddeev calculations show unambiguously the shortcomings of calculations employing only two-body forces and the necessity of including 3NF. They also show the limitations of the latest few-nucleon calculations at backward angles, especially at higher beam energies. Some of these discrepancies could be partially due to relativistic effects. Data at lowest energy are also compared with a recent calculation based on \chipt

Evidence of the Coulomb force effects in the cross sections of the deuteron-proton breakup at 130 MeV

High precision cross-section data of the deuteron-proton breakup reaction at 130 MeV deuteron energy are compared with the theoretical predictions obtained with a coupled-channel extension of the CD Bonn potential with virtual Delta-isobar excitation, without and with inclusion of the long-range Coulomb force. The Coulomb effect is studied on the basis of the cross-section data set, extended in this work to about 1500 data points by including breakup geometries characterized by small polar angles of the two protons. The experimental data clearly prefer predictions obtained with the Coulomb interaction included. The strongest effects are observed in regions in which the relative energy of the two protons is the smallest.Comment: 9 pages, 3 figures, submitted to Physics Letters

A comprehensive review on the applications of exosomes and liposomes in regenerative medicine and tissue engineering

Tissue engineering and regenerative medicine are generally concerned with reconstruct-ing cells, tissues, or organs to restore typical biological characteristics. Liposomes are round vesicles with a hydrophilic center and bilayers of amphiphiles which are the most influential family of na-nomedicine. Liposomes have extensive research, engineering, and medicine uses, particularly in a drug delivery system, genes, and vaccines for treatments. Exosomes are extracellular vesicles (EVs) that carry various biomolecular cargos such as miRNA, mRNA, DNA, and proteins. As exosomal cargo changes with adjustments in parent cells and position, research of exosomal cargo constitu-ents provides a rare chance for sicknesses prognosis and care. Exosomes have a more substantial degree of bioactivity and immunogenicity than liposomes as they are distinctly chiefly formed by cells, which improves their steadiness in the bloodstream, and enhances their absorption potential and medicinal effectiveness in vitro and in vivo. In this review, the crucial challenges of exosome and liposome science and their functions in disease improvement and therapeutic applications in tissue engineering and regenerative medicine strategies are prominently highlighted