Study of Sea level changes with Leckie method of the Abderaz Formation (Middle Turonian-Early Campanian) at type section based on foraminifera

In this research the Abderaz Formation at its type section with an age of Turonian-early Campanian and a thickness of 300 m containing.light grey shale and marls was investigated. Statistical Studise of the morphotype groups of planktonic foraminifera shows that the majority of them are of shallow water forms (SWF) and deep water forms (DWF) and planktonic to benthic ratio is high indicating specific condition of oligotrophy and sedimentation in a relatively deeper marine conditio

COX inhibition: Catalepsy and Striatum Dopaminergic-GABAergic-Glutamatergic Neurotransmission

Selective COX-2 and COX-1 inhibitors were administered (i.p. acutely) to normal and parkinsonian rats, followed by the analysis of the striatal dopamine, GABA and glutamate concentrations using the microdialysis technique, simultaneously, the catalepsy of animals was evaluated. Selective COX-2 inhibition showed improving effects on the catalepsy followed by decreasing the striatum glutamatergic-GABAergic and enhancing the dopaminergic neurotransmission. Nonetheless COX inhibition had no significant improving effects on damaged Substantia Nigra Pars Compacta (SNc) neurons

Relationship between managers’ emotional intelligence and organizational effectiveness: A case study in Farhangian University

The goal of this study is to clarify existing relations between Emotional Coefficient and Organizational Effectiveness (OE) among Farhangian University managers during 2013-14. The sample size, according to Cochran formula, is 156 people, which were selected based on the simplified random sampling. Besides, two questionnaires were used having the reliability index of 0.87 and 0.97 respectively. The findings of this study suggested that there is a direct and positive relation between emotional intelligence along with its subscales including self-awareness, self-adjustment, self-motivation, compassion and social skills found in managers with organizational effectiveness in Farhangian University

Relationship between managers’ emotional intelligence and organizational effectiveness: A case study in Farhangian University

The goal of this study is to clarify existing relations between Emotional Coefficient and Organizational Effectiveness (OE) among Farhangian University managers during 2013-14. The sample size, according to Cochran formula, is 156 people, which were selected based on the simplified random sampling. Besides, two questionnaires were used having the reliability index of 0.87 and 0.97 respectively. The findings of this study suggested that there is a direct and positive relation between emotional intelligence along with its subscales including self-awareness, self-adjustment, self-motivation, compassion and social skills found in managers with organizational effectiveness in Farhangian University

Biostratigraphy of the Ruteh Formation at Harijan section (Central Alborz) northern Iran using foraminifera and conodont

In order to study the fossil contents of the Ruteh Formation for biostratigraphical purposes, the 200 meters thick section was sampled at Harijan section, Central Alborz. The sequence is mainly made up of limestone and shale's. The lower contact of the formation with Dorud Formation is disconform while the upper contact with under learing Dorud Formation is disconformable with overling Nesen Formation is as well as disconformable. Fifty four species belonging to 27 genera (foraminifera and conodonts) were identified and three biozones were differentiated. These are formation: 1- _Schubertella giraudi_- _Codonofusiella distincta_ Assemblage Zone, 2- _Cribrigenerina sumatruna_- _Langella ocarina_ Assemblage Zone, 3- _Sweetognathus whitei_ Biozone. Based on, these an age of Yackhtaschian - Murghabian is quoted to the formation

Synthesis and Evaluation of Antiproliferative Activity of Substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides

Several novel N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides derivatives were prepared as potential antiproliferative agents. The in vitro antiproliferative activity of the synthesized compounds was investigated against a panel of tumor cell lines including breast cancer cell lines (MDA-MB-231, T-47D) and neuroblastoma cell line (SK-N-MC) using MTT colorimetric assay. Etoposide, a well-known anticancer drug, was used as a positive standard drug. Among synthesized compounds, 4-methoxy-N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamide (5i) showed the highest antiproliferative activity against MDA-MB-231, T-47D, and SK-N-MC cells. Furthermore, pentafluoro derivatives 5a and 6a exhibited higher antiproliferative activity than doxorubicin against human leukemia cell line (CCRF-CEM) and breast adenocarcinoma (MDAMB- 468) cells. Structure-activity relationship studies revealed that xanthone benzenesulfonamide hybrid compounds can be used for development of new lead anticancer agents

Synthesis and Evaluation of Cytotoxic Activity of Substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides

Several novel N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides derivatives were prepared as potential antiproliferative agents. The in vitro antiproliferative activity of the synthesized compounds was investigated against a panel of tumor cell lines including breast cancer cell lines (MDA-MB-231, T-47D) and neuroblastoma cell line (SK-N-MC) using MTT colorimetric assay. Etoposide, a well-known anticancer drug, was used as a positive standard drug. Among synthesized compounds, 4-methoxy-N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamide (5i) showed the highest antiproliferative activity against MDA-MB-231, T-47D, and SK-N-MC cells. Furthermore, pentafluoro derivatives 5a and 6a exhibited higher antiproliferative activity than doxorubicin against human leukemia cell line (CCRF-CEM) and breast adenocarcinoma (MDA-MB-468) cells. Structure-activity relationship studies revealed that xanthone benzenesulfonamide hybrid compounds can be used for development of new lead anticancer agents

Synthesis and In Vitro Cytotoxic Activity of N-2-(2-Furyl)-2-(chlorobenzyloxyimino)Ethyl Ciprofloxacin Derivatives

Quinolone are a class of potent broad-spectrum antibacterial drugs that target the bacterial type II DNA topoisomerases (DNA gyrase) and topoisomerase IV. In the present study, the synthesis and evaluation of cytotoxicity activity of a new series of N-pipearzinyl quinolones containing N-2-(furyl-2-yl)-2-(chlorobenzyloxyimino) ethyl moiety (6a-c) have been studied. Preliminary screening showed that one of the new compounds, namely 7-(4-(2-(3-chlorobenzyloxyimino)-2-(furan-2-yl) ethyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6b) showed significant cytotoxic activity against human breast tumor cell lines