The infinite circle :

In the second part of the study the Chiliastic Soul concept is discussed as the goal of unity. This is done by focusing on the Castalian "game" and the death of Joseph Knecht. In addition, evidence is presented for certain fundamental conceptual similarities in the thought of Hesse and Hegel and Hesse and Jung, respectively. The author argues not only for the relevance of dialectics as key to a full understanding of Hesse but for the proposition that Hegel, Jung, and Hesse share a primary intuition of ultimate unity or non-duality which shows striking parallels to the metaphysical foundations of the I Ching, Lao-Tze's tao, and the Vedantic atman-brahman identity. Finally, the death of Joseph Knecht is interpreted as affirmation of transformation in the light of Jungian alchemical symbolism.This interdisciplinary study combines some of the methodological and substantive approaches of philosophy, literary criticism and Jungian psychology to the examination of a mystical concept of atemporal cosmic identity the author calls Chiliastic Soul in G. W. F. Hegel, C. G. Jung, and H. Hesse with particular emphasis on Hegel's Phenomenology, Jung's Mysterium Coniunctionis, and Hesse's Glass Bead Game.In the first part of the study the Chiliastic Soul concept is developed as the process or path of its own becoming in the variations of Hegel's "Path of Comprehension, " the spiritual odyssey from the divine or absolute perspective, Jung's "Path of Individuation, " the spiritual odyssey from the human or subjective perspective, and Hesse's "Path of Awakening, " which represents a fusion or synthesis of the Hegelian and Jungian approaches. This part concludes with the application of Evelyn Underhill's analysis of the Mystical Way to the Paths of Comprehension, Individuation, and Awakening, respectively

The effect of perspective on presence and space perception

In this paper we report two experiments in which the effect of perspective projection on presence and space perception was investigated. In Experiment 1, participants were asked to score a presence questionnaire when looking at a virtual classroom. We manipulated the vantage point, the viewing mode (binocular versus monocular viewing), the display device/screen size (projector versus TV) and the center of projection. At the end of each session of Experiment 1, participants were asked to set their preferred center of projection such that the image seemed most natural to them. In Experiment 2, participants were asked to draw a floor plan of the virtual classroom. The results show that field of view, viewing mode, the center of projection and display all significantly affect presence and the perceived layout of the virtual environment. We found a significant linear relationship between presence and perceived layout of the virtual classroom, and between the preferred center of projection and perceived layout. The results indicate that the way in which virtual worlds are presented is critical for the level of experienced presence. The results also suggest that people ignore veridicality and they experience a higher level of presence while viewing elongated virtual environments compared to viewing the original intended shape.Intelligent SystemsElectrical Engineering, Mathematics and Computer Scienc

Perspectives on ENCODE

The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.11Nsciescopu

Expanded encyclopaedias of DNA elements in the human and mouse genomes

AbstractThe human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development. All data are available through the ENCODE data portal (https://www.encodeproject.org), including phase II ENCODE1 and Roadmap Epigenomics2 data. We have developed a registry of 926,535 human and 339,815 mouse candidate cis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN; http://screen.encodeproject.org) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the organization and function of the human and mouse genomes.11Nsciescopu