Assessment of VEGF, CD-31 and Ki-67 Immunohistochemical Markers in Oral Pyogenic Granuloma: A Comparison with Hemangioma and Inflammatory Gingivitis

AbstractObjective(s) The aim of this study was to evaluate the expressions of two angiogenic immune-markers (CD-31 and VEGF), and one proliferative immune-marker (Ki-67) in oral pyogenic granulomas (PG), hemangiomas (Hem) and inflammatory gingivitis (IG).Materials and MethodsSixty cases of PG, Hem and IG (twenty cases each) were examined. Immunohistochemical (IHC) staining was performed based on routine techniques. The microvessel density (MVD) index was also evaluated. ResultsThe male to female ratio was 1:2. The mean age was 33.3 years old (±20.52). The reactivity percentages for all three markers (CD-31, VEGF and Ki-67) were significantly higher in PG compared to Hem (56.8%, 13.8% and 23.0% vs. 28.3%, 7.0% and 5.4%, respectively). The mean MVD in PG was also significantly higher than in Hem (26.1±0.11 vs. 13.6±0.08). There was no statistically significant difference between PG and IG.ConclusionThe current study supports the common nature of pyogenic granulomas and inflammatory gingivitis

Squamous cell carcinoma arising from an odontogenic keratocyst : a case report

Squamous cell carcinoma (SCC) derived from keratocystic odontogenic tumor is an extremely rare tumor that is limited to the jaws. Most intraosseous carcinomas originate from the epithelial lining of odontogenic cysts, so they are called odontogenic carcinomas. They occur more frequently in men and the mean age of patients is 57 years. The following report describes an extremely rare case of an odontogenic carcinoma derived from a keratocystic odontogenic tumor in a 20-year-old man. The patient presented with an exophytic lesion in the retromolar region of the mandible which was first noticed by the patient 25 days earlier. In panoramic radiograph a well-defined radiolucency around the impacted 3rd molar was observed. Clinical and radiographic diagnosis was odontogenic SCC. Surgical resection was performed and histhopathologic examination of the lesion confirmed the diagnosis of SCC in the wall of a keratocystic odontogenic tumor

A 38- Year Demographic Study of Central and Peripheral Giant Cell Granulomas of the Gaws

Objective: The purpose of this study was to retrospectively analyze the demographic characteristics of patients with central peripheral giant cell granulomas (CGCGs) / (PGCGs) an Iranian population.Methods: In this 38-year retrospective study, the data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to the Department of Oral and Maxillofacial, Pathology, Mashhad University of Medical Sciences, Iran between 1972 and 2010. Information regarding age distribution, gender, location of the lesion and clinical signs and symptoms was documented.Results: A total of 1019 patients were affected by giant cell granuloma lesions (GCGLs) including 435 CGCGs and 584 PGCGs. The mean age was 28.91 ± 18.16. PGCGs and CGCGs had a peak of occurrence in the first and second decade of life respectively. A female predominance was shown in CGCG cases (57.70%), whereas PGCGs were more frequent in males (50.85%). Five hundred and ninety eight cases of all giant cell lesions (58.7 %) occurred in the mandible. Posterior mandible was the most frequent site for both Lesions. The second most common site for PGCG was posterior maxilla (21%), whereas anterior mandible was involved in CGCG (19.45%). The majority of patients were asymptomatic. Patient's age, location (mandible/maxilla) and bleeding were the influential variables on the type of the lesion.Conclusion: Although the CGCGs share some histopathologic similarities with PGCGs, differences in demographic features may be observed in different populations

Evaluation of High-Sensitivity C-Reactive Protein and Irisin in Saliva and Serum of Patients with Myocardial Infarction

Introduction: Cardiovascular diseases are the leading cause of mortality worldwide. Despite the importance of early diagnosis and advances in medicine, one-third of Myocardial Infarction (MI) cases remain undiagnosed. Biomarkers are a reflection of the physiologic function and pathologic changes in the body. Saliva is a refined plasma that can replace blood to facilitate and accelerate the diagnosis process given the benefits of its collection and storage. The present study aimed to investigate the correlation between serum and saliva hs-CRP and Irisin concentration in MI patients.Materials and Methods: In this case-control study, 46 cases were selected including 24 acute MI and 22 controls. The serum and saliva samples were collected and the amount of Irisin and hs-CRP was measured in each sample in the specialized biochemistry laboratory of Mashhad Medical School. Data were analyzed using SPSS (version 22) by Pearson correlation coefficient test (P<0.05).Results: The concentration of Saliva Irisin was significantly lower in the patient group than that in the control group (P=0.021). The levels of serum and salivary hs-CRP were significantly higher in the patient group than those in the control group (for both P<0.001). The concentration of marker in saliva significantly increased as the concentration of marker increased in serum (P<0.001).Conclusion: Measurement and reduction of salivary Irisin concentrations can be a reliable criterion for diagnosing and predicting MI. The concentration of hs-CRP in saliva and serum is directly related to MI

Glandular Odontogenic Cyst Associated with Impacted Tooth: A Case Report

Glandular odontogenic cyst (GOC) is an uncommon developmental cyst. It accounts for 0.012% to 1.3% of all the jaw cysts; its prevalence is 0.17%. It was described by Gardner et al. in 1988 as a distinct entity. GOC has a slight predilection for mandible and affect more commonly in the middle-aged patients. Radiographic and clinical features of this cyst are not pathognomonic or specific. Only the histopathological examinations allow for certain diagnosis of the cyst. The increased recurrence rate can be due to cell kinetics in the lining epithelium, multilocularity and incomplete removal of the lining following conservative treatment. In this report, we describe a case of GOC of the mandible associated with impacted tooth. The clinical diagnosis of dentigerous cyst was made, whereas histopathological examination results in a diagnosis of glandular odontogenic cyst. Based on clinical and radiological examination the diagnosis of other lesions such as radicular cyst, dentigerous cyst, and ameloblastoma may be made but histologically GOC shows certain characteristic features

Central Granular Cell Odontogenic Tumor: Report of a Case with CBCT Features.

Central granular cell odontogenic tumor) CGCOT) of the jaw is an exceedingly rare benign odontogenic neoplasm with 35 reported cases in the literature. Among these, very few studies have focused on the cone-beam CT features of CGCOT. Here, we report a case of an asymptomatic CGCOT in a 16-year-old girl and focus on the cone-beam CT features. Only 36 cases of this lesion, including this one, have been reported so far. The case presented is of special importance due to the young age of the patient, the posterior location of the lesion and the multilocular pattern in the cone beam CT images

ПРИМЕНЕНИЕ ВОЗОБНОВЛЯЕМЫХ ИСТОЧНИКОВ ЭНЕРГИИ В РОССИЙСКОЙ ФЕДЕРАЦИИ

Objectives: Multifocal epithelial hyperplasia (MEH) is benign, asymptomatic oral disease with viral etiology. The frequency of this disease varies widely from one geographic region to another, and can vary, from 0.002 to 35% depending on the population studied. Study design: Here we report the clinicopathological features of twelve cases of MEH referred to Oral Medicine Department of Mashhad Dental School for the first time in Iran. Records of patients with the diagnosis of MEH in our department during 7 years were analyzed and data were extracted. Results: Most of the patients were younger than 20-year-old (66%), and females were predominantly affected (7:12). The mean age of onset was 12.72±10.14 years and the mean duration was 52.54 ± 78.51 months. Patients had multiple, well circumscribed, soft, non tender, flattened papules, with a color similar to the adjacent mucosa, in different areas of the oral cavity but the most affected site was buccal mucosa. Familial history of such lesions was negative in all patients. Only three cases showed spontaneous regression. Conclusion: In spite of rare nature of this disease in Asia, it seems that it is not the case in Khorasan Province, southeast Iran

Mandibular Swelling as the First Manifestation of Multiple Myeloma

Multiple myeloma is a monoclonal malignant proliferationof plasma cells. The disease is more frequent in men, andthe average age of patients at the time of diagnosis of thedisease is about 60 years. Solitary myeloma may be the firstmanifestation of the disseminated form of multiple myeloma,which is characterized by multiple skeletal lesions,general metabolic alterations, impairment of renal functionand eventually death.The findings in regards to the present case suggest that oralmanifestations may be the first sign of multiple myeloma. Thismight highlight the important role that a dentist can have inthe early diagnosis of the disease.Iran J Med Sci 2010; 35(4): 331-334

Intraoral ancient schwannoma: A systematic review of the case reports

Intraoral ancient schwannoma is a rare type of oral schwannoma, which is encapsulated and well demarcated from the surrounding tissues. Ancient schwannomas are associated with conventional features of neurilemmoma; however, they are distinguished from other types of schwannoma due to factors such as the long history, cellular architecture showing hypocellularity, and hyalinized matrices. This systematic review was performed through searching in databases such as PubMed and Google Scholar using related keywords (intraoral, oral, ancient, schwannoma, and neurilemmoma). Eventually, 26 case reports were systematically reviewed by the researchers. Required data were extracted by one researcher, and all the selected articles were reviewed in full text after screening. This systematic review aimed to determine the most significant influential factors in intraoral ancient schwannoma and evaluate the diagnostic and therapeutic methods in this regard

Ancient schwannoma of oral cavity: A case report

Introduction: Ancient schwannoma is a rare variant of schwannoma that rarely occurs in the oral cavity. Histologically it can be confused with a malignant mesenchymal tumor. Therefore it is important to differentiate them from each other. Case report: The patient was a 40 – year – old male with the complaint of a painless gradual swelling in the left side of the mandibular lingual gingiva for about 5 years. No sign of bone resorption was found in periapical radiographs. After the excision of lesion, histopathologic examination showed proliferation of Schwann cells, degenerative changes including nuclear atypia, hyalinization and myxoid areas and calcification. Immunohistochemical analysis revealed strong positive staining for S-100 protein. All these features were consistent with diagnosis of ancient schwannoma