Crystal structure of 3-{(E)-[(3, 4-dichloro-phenyl)imino]methyl}benzene-1, 2-diol

The authors acknowledge the provision of funds for the purchase of diffractometer and encouragement by Dr.Muhammad Akram Chaudhary, Vice Chancellor, University of Sargodha, Pakistan.Peer reviewedPublisher PD

4-(5-Chloro-2-hydroxy­benzyl­idene­amino)-N-(4,6-dimethyl­pyrimidin-2-yl)benzene­sulfonamide

The title compound, C19H17ClN4O3S, is a Schiff base compound of 5-chloro­salicylaldehyde and sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidin­yl)benzene­sulfonamide]. The geometry around the S atom is distorted tetra­hedral, comprising two O atoms of the sulfonyl group, a C atom of a benzene ring and the amino N atom. The title compound has an intra­molecular O—H⋯N hydrogen bond and two inter­molecular C—H⋯O and N—H⋯O hydrogen bonds, which link neighbouring mol­ecules into 10-membered rings. As a result of an unavoidable conformational arrangement, a slightly short intra­molecular contact of distance 2.59 Å exists between an O atom of the sulfonyl group and an H atom of the sulfamethazine benzene ring

4-[(E)-(5-Chloro-2-hydroxy­benzyl­idene)amino]benzene­sulfonamide

In the mol­ecule of title compound, C13H11ClN2O3S, the aromatic rings are oriented at a dihedral angle of 12.27 (3)°. An intra­molecular O—H⋯N hydrogen bond results in the formation of a planar (mean deviation 0.0083 Å) six-membered ring, which is nearly coplanar with the adjacent ring at a dihedral angle of 2.36 (13)°. In the sulfonamide group, the S atom is 0.457 (3) Å from the plane through the O and N atoms. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules

Prediction of strain values in reinforcements and concrete of a RC frame using neural networks

The level of strain in structural elements is an important indicator for the presence of damage and its intensity. Considering this fact, often structural health monitoring systems employ strain gauges to measure strains in critical elements. However, because of their sensitivity to the magnetic fields, inadequate long-term durability especially in harsh environments, difficulties in installation on existing structures, and maintenance cost, installation of strain gauges is not always possible for all structural components. Therefore, a reliable method that can accurately estimate strain values in critical structural elements is necessary for damage identification. In this study, a full-scale test was conducted on a planar RC frame to investigate the capability of neural networks for predicting the strain values. Two neural networks each of which having a single hidden layer was trained to relate the measured rotations and vertical displacements of the frame to the strain values measured at different locations of the frame. Results of trained neural networks indicated that they accurately estimated the strain values both in reinforcements and concrete. In addition, the trained neural networks were capable of predicting strains for the unseen input data set

Tris[bis­(2-methyl­prop­yl)dithio­phosphinato]bis­muth(III)

The title compound, [Bi(C8H18PS2)3], contains a BiIII cation surrounded by three bis­(2-methyl­prop­yl)dithio­phosphinate anions, leading to a distorted octa­hedral coordination for the heavy metal. The Bi—S and S—P bond lengths are in the ranges 2.7694 (18)–2.8391 (17) and 2.019 (2)–2.035 (2) Å, respectively. The crystal structure is consolidated by C—H⋯S hydrogen bonds. Intra­molecular C—H⋯π inter­actions also play a role in stabilizing the mol­ecules

4-Chloro-2-[(E)-({4-[N-(3,4-dimethyl­isoxazol-5-yl)sulfamo­yl]phen­yl}iminio)meth­yl]phenolate

The title compound, C18H16ClN3O4S, is a Schiff base ligand in which the H atom of the hydr­oxy group has moved to the N atom of the imine group, resulting in a zwitterion. The structure is stabilized by an intra­molecular (N—H⋯O) and five inter­molecular (C—H⋯O, C—H⋯N and N—H⋯O) hydrogen bonds. The mol­ecules are linked to each other by hydrogen bonds and form a three-dimensional polymeric network. In addition, the aromatic rings are also involved in π–π inter­actions [centroid–centroid distance between aromatic rings = 3.7525 (11) Å]

Effects of administration of a growth promoting implant during the suckling phase or at weaning on growth, reproduction, and ovarian development in replacement heifers grazing native range

Management strategies utilized during pre-breeding development of replacement heifers can impact fertility and the ovarian reserve. Angus- Hereford crossbred heifers (n = 233) were utilized over a 3-yr period to determine the effects of administration of a growth promoting implant at either branding or weaning on growth, reproduction, and ovarian development. Heifer calves were randomly assigned to one of three treatments: 1) nonimplanted controls (CON; n = 79), 2) implanted at approximately 2 mo of age (average calf age = 58 d) with Synovex-C (BIMP, n = 82), or 3) implanted at approximately 7 mo of age (average calf age = 210 d) with Synovex-C (WIMP; n = 72). In years 2 and 3, a subset of heifers (year 2 n = 16; year 3 n = 14) were unilaterally ovariectomized. Heifers implanted at 2 mo of age were heavier at weaning, yearling (mid-February; average calf age = 332 d), and at the beginning of the breeding season (P \u3c 0.01) compared to CON and WIMP heifers. Average daily gain (ADG) was similar among treatments from weaning to yearling and weaning to the start of the breeding season (P ≥ 0.61); however, WIMP heifers had increased (P = 0.05) ADG from yearling to the start of the breeding season compared to BIMP heifers. Antral follicle count and reproductive tract scores were not influenced by implant treatment (P ≥ 0.18). Response to synchronization of estrus was increased (P = 0.02) in WIMP compared to CON heifers, with BIMP heifers similar to all other treatments. First service conception rates tended to be increased (P = 0.09) in CON heifers compared to WIMP heifers, with BIMP heifers similar to CON and WIMP. Final pregnancy rates were similar (P = 0.54) among treatments. A treatment × yr interaction was detected (P = 0.01) for the number of primordial follicles/section with increased primordial follicles in WIMP heifers in year 3 compared to BIMP and WIMP heifers in year 2 and CON heifers in year 3, as well as in BIMP compared to WIMP heifers in year 2. Utilization of growth promoting implants did not negatively impact postweaning reproductive development or compromise pregnancy rates in beef heifers. Based on these results, administration of a growth promoting Synovex-C implant at 2 mo of age may allow for increased body weight at weaning, without hindering reproductive performance

Benign perimesencephalic hemorrhage occurring after previous aneurysmal subarachnoid hemorrhage: a case report

<p>Abstract</p> <p>Introduction</p> <p>Both aneurysmal subarachnoid hemorrhage and benign perimesencephalic hemorrhage are well-described causes of spontaneous subarachnoid hemorrhage that arise as a result of different pathologic processes. To the best of the authors' knowledge, there have been no reports of both vascular pathologies occurring in the same individual.</p> <p>Case presentation</p> <p>A 51-year-old Caucasian woman with a history of aneurysmal subarachnoid hemorrhage presented five years after her initial treatment with ictal headache, meningismus, nausea and emesis similar to her previous bleeding event. Computed tomographic imaging revealed perimesencephalic bleeding remote from her previously coiled anterior communicating artery aneurysm. Both immediate and delayed diagnostic angiography revealed no residual filling of the previously coiled aneurysm and no other vascular anomalies, consistent with benign perimesencephalic hemorrhage. The patient had an uneventful hospital course and was discharged to home in good condition.</p> <p>Conclusions</p> <p>This report for the first time identifies benign perimesencephalic hemorrhage occurring in the setting of previous aneurysmal subarachnoid hemorrhage. The presence of a previously treated aneurysm can complicate the process of diagnosing benign perimesencephalic hemorrhage. Fortunately, in this case, the previously treated anterior communicating artery aneurysm was remote from the perimesencephalic hemorrhage and could be ruled out as a source. The patient's prior aneurysmal subarachnoid hemorrhage did not worsen the anticipated good outcome associated with benign perimesencephalic hemorrhage.</p

Perspectives of the Apiaceae Hepatoprotective Effects - A Review

The liver has the crucial role in the regulation of various physiological processes and in the excretion of endogenous waste metabolites and xenobiotics. Liver structure impairment can be caused by various factors including microorganisms, autoimmune diseases, chemicals, alcohol and drugs. The plant kingdom is full of liver protective chemicals such as phenols, coumarins, lignans, essential oils, monoterpenes, carotenoids, glycosides, flavonoids, organic acids, lipids, alkaloids and xanthenes. Apiaceae plants are usually used as a vegetable or as a spice, but their other functional properties are also very important. This review highlights the significance of caraway, dill, cumin, aniseed, fennel, coriander, celery, lovage, angelica, parsley and carrot, which are popular vegetables and spices, but possess hepatoprotective potential. These plants can be used for medicinal applications to patients who suffer from liver damage