Assessment of Surrogate Markers for Cardiovascular Disease in Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous for M694V Mutation in MEFV Gene

Cardiovascular disease (CVD) remains underestimated in familial Mediterranean fever-associated AA amyloidosis (FMF-AA). We aimed to compare early markers of endothelial dysfunction and atherosclerosis in FMF-AA with a homozygous M694V mutation (Group 1 = 76 patients) in the Mediterranean fever (MEFV) gene and in patients with other genotypes (Group 2 = 93 patients). Measures of increased risk for future CVD events and endothelial dysfunction, including flow-mediated dilatation (FMD), pentraxin-3 (PTX3), and carotid intima-media thickness (cIMT), and fibroblast growth factor 23 (FGF23) as a marker of atherosclerotic vascular disease were compared between groups. The frequency of clinical FMF manifestations did not differ between the two groups apart from arthritis (76.3% in Group 1 and 59.1% in Group 2, p \u3c 0.05). FMD was significantly lower in Group 1 when compared with Group 2 (MD [95% CI]: −0.6 [(−0.89)–(−0.31)]). cIMT, FGF23, and PTX3 levels were higher in Group 1 (cIMT MD [95% CI]: 0.12 [0.08–0.16]; FGF23 MD [95% CI]: 12.8 [5.9–19.6]; PTX3 MD [95% CI]: 13.3 [8.9–17.5]). In patients with FMF-AA, M694V homozygosity is associated with lower FMD values and higher cIMT, FGF23, and PTX3 levels, suggesting increased CVD risk profiles. These data suggest that a genotype–phenotype association exists in terms of endothelial dysfunction and atherosclerosis in patients with FMF-AA

Assessment of Surrogate Markers for Cardiovascular Disease in Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous for M694V Mutation in MEFV Gene

Cardiovascular disease (CVD) remains underestimated in familial Mediterranean fever-associated AA amyloidosis (FMF-AA). We aimed to compare early markers of endothelial dysfunction and atherosclerosis in FMF-AA with a homozygous M694V mutation (Group 1 = 76 patients) in the Mediterranean fever (MEFV) gene and in patients with other genotypes (Group 2 = 93 patients). Measures of increased risk for future CVD events and endothelial dysfunction, including flow-mediated dilatation (FMD), pentraxin-3 (PTX3), and carotid intima-media thickness (cIMT), and fibroblast growth factor 23 (FGF23) as a marker of atherosclerotic vascular disease were compared between groups. The frequency of clinical FMF manifestations did not differ between the two groups apart from arthritis (76.3% in Group 1 and 59.1% in Group 2, p \u3c 0.05). FMD was significantly lower in Group 1 when compared with Group 2 (MD [95% CI]: −0.6 [(−0.89)–(−0.31)]). cIMT, FGF23, and PTX3 levels were higher in Group 1 (cIMT MD [95% CI]: 0.12 [0.08–0.16]; FGF23 MD [95% CI]: 12.8 [5.9–19.6]; PTX3 MD [95% CI]: 13.3 [8.9–17.5]). In patients with FMF-AA, M694V homozygosity is associated with lower FMD values and higher cIMT, FGF23, and PTX3 levels, suggesting increased CVD risk profiles. These data suggest that a genotype–phenotype association exists in terms of endothelial dysfunction and atherosclerosis in patients with FMF-AA

Finite groups in which any two abelian subgroups of the same order are conjugate

Ph.D. - Doctoral Progra

The achilles mosaic of Prusias ad Hypium

Akhilleus Mozaiği, 1950’li yıllarda Prusias ad Hypium kentinin güney tarafındaki bir tarlada tesadüfen bulunmuştur ve kentteki bir Roma villasının zemininde yer almış olan bir taban mozaiğidir. Çok az bir kısmı korunmuş olan mozaik parçası üzerinde üç adet yazıt bulunmaktadır. Bu yazıtta sol başta Genç Kızlar (παρθένοι), ortada Deidameia (Δηιδαμεία) ve onun sağında Purrhos (Πύρρ̣ο[ς]) yazmaktadır. Yazıtlardan da anlaşıldığı gibi bu mozaikte Skyros Adası’nda Kral Lycomedes’in Sarayı’nda Akhilleus’un, Odysseus tarafından ortaya çıkarılması tasvir edilmiştir. Sahnenin sağ üst köşesinde en üstte yazılmış olan Parthenoi yani Antik Yunanca anlamıyla “Genç Kızlar” hikâyenin geçtiği Lykomedes’in Sarayı’ndaki mozaikte arka planda bulunan Lykomedes’in genç kızlarını ima etse de aslında bu sahnenin bu temayı işleyen ve Parthenoi (Genç Kızlar) olarak adlandırılmış tragedya veya pandomim için yazılmış ve günümüze kadar ulaşmamış bir edebi tiyatro eserinin adı olduğunu bize göstermektedir. Aynı durum Zeugma Akhilleus Mozaiği’nde (Quintus Calpurnius Eutykhes Evi’ndeki) de görülmektedir. Bu sahnenin etrafını dalgalı kurdele bandı çevirmektedir. Bundan sonra mozaiği, günlük hayattan iki sahne olan av ve ziyafet sahnesi çevirmiştir. Mozaik en dışta ise geometrik bir bordür ile sonlandırılmıştır. Prusias ad Hypium Akhilleus mozaiği sahip olduğu stilistik ve ikonografik özellikler itibariyle İS 3. yüzyılın ortalarına ait olmalıdır.The Mosaic of Achilles was discovered coincidentally in a field in the southern region of Prusias ad Hypium in the 1950s. It is a floor mosaic situated on the ground of a Roman villa in the city. Only a very small part of the mosaic remains on which there are three inscriptions. These inscriptions involve words Young Girls (παρθένοι) on the left, Deidameia (Δηιδαμεία) in the middle and Pyrrhus (Πύρρ̣ο[ς]) on the right. As understood from the inscriptions, this mosaic depicts the discovery of Achilles by Odysseus in King Lycomedes’ palace in Skyros Island. The word Parthenoi meaning Young Girls in ancient Greek written at the top of the upper right corner of the scene implies the young daughters of Lycomedes at the background of the mosaic in Lycomedes’ palace where the story takes place, however it in fact shows the title of a lost literary drama written about this theme for tragedy or pantomime which did not reach the present day. The same situation applies to the Zeugma Achilles Mosaic (at the house of Quintus Calpurnius Eutykhes). The scene is surrounded by a wavy ribbon band. This is followed by hunting and feast scenes both from daily life. Finally, the outermost border is a geometric one. Due to its stylistic and iconographic characteristics, the Prusias ad Hypium Achilles mosaic is estimated to date back to mid-third century AD

Prusias ad Hypium Orpheus mozaiği

The mosaic of Orpheus was discovered coincidentally in a field in the southern region of the city in the 1950s. It is a floor mosaic arranged in rectangular form situated on the ground of a Roman villa in the city. The base of the mosaic measures 8.10 x 5.30 m. Orpheus is the son of Oeagrus, the king of Thrace and Calliope the Muse. When Orpheus started playing his lyre, as the melody he uttered was combined with the extraordinarily harmonious music of the lyre, even the wildest animals were tamed, the birds flying in the sky halted to listen to him, and the trees and the rocks caught in the harmony of the music accompanied him by swaying and saluting. The mosaic of Prusias ad Hypium is arranged in a conventional style with Orpheus sitting on a rock as a central figure being surrounded by the animals of paradeisos. The personifications of four separate seasons are placed at the four corners of the round panel in the center of which Orpheus sat. A guilloche in a single row is used in the frame decoration of the panel where Orpheus, the animals and the four seasons are present. The border in the shape of a rectangle comprising intersecting circles consists of two rows at the upper short edge, three rows at the lower short edge and one row at each of the long edges. The border consisting of consecutive dark brown triangles is the outermost pattern encircling the mosaic. Rock, tree or plant motifs that are the indicators of natural environment are not used. The Orpheus mosaic of Prusias ad Hypium should belong to late 3rd-early 4th century A.D. owing to its stylistic and iconographic features.Orpheus mozaiği 1950’li yıllarda şehrin güney tarafındaki bir tarlada tesadüfen bulunmuştur. Kentteki bir Roma villasının zemininde yer almış olan bir taban mozaiğidir ve dikdörtgen bir biçimde düzenlenmiştir. Mozaik tabanı 8,10 x 5,30 m. ölçülerindedir. Orpheus; Trakya kralı Oiagros ve Muse Kalliope’nin oğludur. Orpheus lirini eline alıp çalmaya başladığında ağzından dökülen ezgiler lirden çıkan olağanüstü ahenkteki müzik ile birleştiğinde en vahşi hayvanlar bile uysallaşır, gökte uçan kuşlar onu dinlemek için durur, müziğin ahengine kapılan ağaçlar ve kayalar sağa sola sallanarak onu selamlayıp ona eşlik ederlerdi. Prusias ad Hypium mozaiği, Orpheus’un merkez bir figür olarak bir kaya üzerine oturmuş olması ve etrafının paradeisos’un hayvanları tarafından çevrelenmesiyle geleneksel bir biçimde düzenlenmiştir. Orpheus’un merkezine oturduğu yuvarlak panonun dört köşesine dört ayrı mevsimin personifikasyonu yerleştirilmiştir. Orpheus ve hayvanlar ile mevsimlerin bulunduğu panonun çerçeve süslemesinde tek sıra halinde sarılı ikili halat kullanılmıştır. İç içe geçerek kesişen dairelerden oluşan dikdörtgen biçimindeki bordür; üst kısa kenarda iki sıra, alt kısa kenarda üç sıra, uzun kenarlarda ise tek sıradır. Koyu kahverengi art arda sıralanmış üçgenlerden oluşan bordür, mozaiği en dışta çeviren son desendir. Doğal ortamın göstergesi olan kaya, ağaç ve bitki motifleri kullanılmamıştır. Prusias ad Hypium Orpheus mozaiği, sahip olduğu stilistik ve ikonografik özellikler itibariyle İ.S. 3. yüzyılın sonu-4. yüzyılın başlarına ait olmalıdır

Transgenic plants for the production of immunogenic proteins

The vaccines are very effective vehicles for the prevention of various diseases. The cost of production and the need of cold-chain limit the vaccination programs especially in low-income countries. Hence, the plants offer a suitable platform to produce the immunogenic proteins with reduced cost without a requirement for cold-chain. The transgenic plants expressing antigens might be either used for the purification of the recombinant proteins or consumed as a food for the oral administration of the plant-based vaccine. A variety of plants have been used as the expression system, such as tobacco, rice, maize, carrot, soybean, potato and barley, each plant possessing pros and cons. Agrobacterium-mediated transformation, biolistics or electroporation techniques are used for the transformation of the plants, and the transgenic plants can be utilized for the development of vaccines against bacterial pathogens such as Mycobacterium tuberculosis, Bacillus anthracis, and viral diseases like Human Papillomavirus, Human Immunodeficiency Virus, as well as the diseases like cancer, synucleopathies or atherosclerosis

A Novel Characterization for Certain Semigroups by Soft Union Ideals

In this paper, we characterize semisimple semigroups, duo semigroups, right (left) zero semigroups, right (left) simple semigroups, semilattice of left (right) simple semigroups, semilattice of left (right) groups and semilattice of groups in terms of soft union semigroups, soft union ideals of semigroups. Moreover, we define soft normal semigroups and give some characterizations of semigroups with soft normality

Uni-soft Substructures of Rings and Modules

In this paper, we introduce union soft subrings and union soft ideals of a ring and union soft submodules of a left module and investigate their related properties with respect to soft set operations, anti image and lower $\alpha$-inclusion of soft sets. We also obtain significant relation between soft subrings and union soft subrings, soft ideals and union soft ideals, soft submodules and union soft submodule