Reliable, resilient and sustainable urban drainage systems: an analysis of robustness under deep uncertainty (article)

This is the author accepted manuscript. The final version is available from the American Chemical Society via the DOI in this record.The dataset associated with this article is available in ORE at: https://doi.org/10.24378/exe.563Reliability, resilience and sustainability are key goals of any urban drainage system. However, only a few studies have recently focused on measuring, operationalizing and comparing such concepts in a world of deep uncertainty. In this study, these key concepts are defined and quantified for a number of gray, green and hybrid strategies, aimed at improving the capacity issues of an existing integrated urban wastewater system. These interventions are investigated by means of a regret-based approach, which evaluates the robustness (that is the ability to perform well under deep uncertainty conditions) of each strategy in terms of the three qualities through integration of multiple objectives (i.e. sewer flooding, river water quality, combined sewer overflows, river flooding, greenhouse gas emissions, cost and acceptability) across four different future scenarios. The results indicate that strategies found to be robust in terms of sustainability were typically also robust for resilience and reliability across future scenarios. However, strategies found to be robust in terms of their resilience and, in particular, for reliability did not guarantee robustness for sustainability. Conventional gray infrastructure strategies were found to lack robustness in terms of sustainability due to their unbalanced economic, environmental and social performance. Such limitations were overcome, however, by implementing hybrid solutions that combine green retrofits and gray rehabilitation solutions.This study was funded by the UK Engineering and Physical Sciences Research Council through STREAM (EP/G037094/1) with Northumbrian Water Limited, BRIM (EP/N010329/1) and the final author’s fellowship Safe & SuRe (EP/K006924/1)

Understanding Islam: Development, Economics and Finance

In this paper, the foundational rules governing human, economic and financial development in Islam, as understood from the Quran and from the life and traditions of the Prophet Muhammad (pbuh), are summarized. These rules pave the path to development as the basis of institutional structure, which in turn, underpin the path of economic and social progress. The essential elements in the life of a Muslim—the unity of creation, freedom and freedom of choice, economic and human development, economic system and financial practice—are developed

Reliable, resilient and sustainable urban drainage systems: an analysis of robustness under deep uncertainty (dataset)

The article associated with this dataset is located in ORE at: http://hdl.handle.net/10871/33480This is the dataset used for the Casal-Campos et al. (2018) article "Reliable, resilient and sustainable urban drainage systems: an analysis of robustness under deep uncertainty" published in Environmental Science and Technology (ES&T).UK Engineering and Physical Sciences Research Council through STREAM (EP/G037094/1)UK Engineering and Physical Sciences Research Council through BRIM (EP/N010329/1)UK Engineering and Physical Sciences Research Council through Prof David Butler's EPSRC fellowship called Safe & SuRe (EP/K006924/1

Limited role for transforming growth factor-β pathway activation-mediated escape from VEGF inhibition in murine glioma models

BACKGROUND The vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-β pathways regulate key biological features of glioblastoma. Here we explore whether the TGF-β pathway, which promotes angiogenesis, invasiveness, and immunosuppression, acts as an escape pathway from VEGF inhibition. METHODS The role of the TGF-β pathway in escape from VEGF inhibition was assessed in vitro and in vivo and by gene expression profiling in syngeneic mouse glioma models. RESULTS We found that TGF-β is an upstream regulator of VEGF, whereas VEGF pathway activity does not alter the TGF-β pathway in vitro. In vivo, single-agent activity was observed for the VEGF antibody B20-4.1.1 in 3 and for the TGF-β receptor 1 antagonist LY2157299 in 2 of 4 models. Reduction of tumor volume and blood vessel density, but not induction of hypoxia, correlated with benefit from B20-4.1.1. Reduction of phosphorylated (p)SMAD2 by LY2157299 was seen in all models but did not predict survival. Resistance to B20 was associated with anti-angiogenesis escape pathway gene expression, whereas resistance to LY2157299 was associated with different immune response gene signatures in SMA-497 and GL-261 on transcriptomic profiling. The combination of B20 with LY2157299 was ineffective in SMA-497 but provided prolongation of survival in GL-261, associated with early suppression of pSMAD2 in tumor and host immune cells, prolonged suppression of angiogenesis, and delayed accumulation of tumor infiltrating microglia/macrophages. CONCLUSIONS Our study highlights the biological heterogeneity of murine glioma models and illustrates that cotargeting of the VEGF and TGF-β pathways might lead to improved tumor control only in subsets of glioblastoma

Reliable, Resilient and Sustainable Urban Drainage Systems: An Analysis of Robustness under Deep Uncertainty

Reliability, resilience and sustainability are key goals of any urban drainage system. However, only a few studies have recently focused on measuring, operationalizing and comparing such concepts in a world of deep uncertainty. In this study, these key concepts are defined and quantified for a number of gray, green and hybrid strategies, aimed at improving the capacity issues of an existing integrated urban wastewater system. These interventions are investigated by means of a regret-based approach, which evaluates the robustness (that is the ability to perform well under deep uncertainty conditions) of each strategy in terms of the three qualities through integration of multiple objectives (i.e., sewer flooding, river water quality, combined sewer overflows, river flooding, greenhouse gas emissions, cost and acceptability) across four different future scenarios. The results indicate that strategies found to be robust in terms of sustainability were typically also robust for resilience and reliability across future scenarios. However, strategies found to be robust in terms of their resilience and, in particular, for reliability did not guarantee robustness for sustainability. Conventional gray infrastructure strategies were found to lack robustness in terms of sustainability due to their unbalanced economic, environmental and social performance. Such limitations were overcome, however, by implementing hybrid solutions that combine green retrofits and gray rehabilitation solutions

An Analysis of Domestic Water Consumption in Jaipur, India

Aim: To explore the relation between water consumption and water use behaviour and attitudes, and devices applied in households in urban areas in India. Methodology and Study Site: This paper presents the results of a domestic water consumption survey carried out in Jaipur, India. A questionnaire containing over 60 questions was developed to collect information on households’ characteristics (e.g. family size, household type, and number of children), indoor and outdoor water use activities and their respective frequencies and durations. Information was also gathered on the volume of water used in each of these activities. Over 90 households of different types (standalone houses and apartments in a university campus and Jaipur city) participated in the survey. The survey results were analysed using cluster analysis and one-way analysis of variance (ANOVA). Results: The results show that the per capita consumption varies considerably with household type and size. The average water consumption was 183 and 215 litres/person/day for standalone households and apartments, respectively. Water used in bathing and WC's represent the highest proportion of water consumption in both stand-alone houses and apartments. Over 40% of the households reported no use of showers. The per capita water consumption is inversely related to family size especially in stand-alone houses. Conclusion: The information pertaining to water use habits and the qualitative and quantitative analysis can be used as an input to a proposed domestic water efficiency tool (DoWET) which can generate optimal water efficient composite strategies keeping in view a range of sustainability indicators including water saving potential, cost and associated energy consumption of the water saving devices and fixtures available in India

Development and Application of a Multi-Objective-Optimization and Multi-Criteria-Based Decision Support Tool for Selecting Optimal Water Treatment Technologies in India

Despite considerable efforts to improve water management, India is becoming increasingly water stressed due to multiple factors, including climate change, increasing population, and urbanization. We address one of the most challenging problems in the design of water treatment plants: how to select a suitable technology for a specific scenario or context. The process of decision making first requires the identification of feasible treatment configurations based on various objectives and criteria. In addition, the multiplicity of water quality parameters and design variables adds further complexity to the process. In this study, we propose a novel Decision Support Tool (DST), designed to address and support the above challenges. In this user-friendly tool, both Multi-Criteria Decision Analysis (MCDA) and Multi-Objective Optimization (MOO) methods are employed. The integration of MCDA with MOO facilitates the generation of feasible drinking water treatment solutions, identifies optimal options, and ultimately, improves the process of decision making. This implemented approach has been tested for different contexts, including for different types of raw water sources and system implementation scales. The results show that this tool can enhance the process of decision making, supporting the user (e.g., stakeholders and decision makers) to implement the most suitable water treatment systems, keeping in view the trade-offs