8 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-Gómez A.
- Adarmes-Gómez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- Alarcón-Martín Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
- Amin N.
- Amouyel Philippe
- Anastasiou A.
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- Andrade V.
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- Publication date
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- Field of study
Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Shear Localization in Dynamic Deformation: Microstructural Evolution
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- A. Hines
- A. Marchand
- A. Marchand
- A. Mishra
- A. Molinari
- A. Molinari
- A. Molinari
- A. Molinari
- A. Rosakis
- A.H. Chokshi
- A.J. Bedford
- A.J. Bedford
- A.K. Zurek
- A.L. Wingrove
- A.L. Wingrove
- A.L. Wingrove
- A.W. Weeber
- A.W. Weeber
- A.Y. Yermakov
- B. Derby
- B. Dodd
- B. Dodd
- B.K. Kad
- C. Fressengeas
- C. Mataya
- C. Politis
- C. Zener
- C.A. Bronkhorst
- C.C. Koch
- C.E. Shamblen
- C.L. Wittman
- C.O. Mgbokwere
- D. Jia
- D. Li
- D. Xing
- D.A. Drew
- D.A. Hughes
- D.A. Hughes
- D.A. Shockey
- D.E. Grady
- D.G. Brandon
- D.G. Lee
- D.R. Chichili
- E. Cerreta
- E. Gaffet
- E. Grady
- E. Hellstern
- E.M. Trent
- F. Spaepen
- F.H. Wu
- F.H. Wu
- F.J. Humphreys
- G. Lutjering
- G. Subhash
- G..B. Olson
- G.B. Olson
- H.A. Grebe
- H.C. Rogers
- H.C. Rogers
- H.C. Rogers
- H.J. Frost
- H.J. Kestenbach
- H.S. Kim
- J. Duffy
- J. Hynes
- J. Lemonds
- J. Pan
- J.A. Hines
- J.F.C. Lins
- J.G.. Sevillano
- J.H. Andrews
- J.H. Beatty
- J.H. Giovanola
- J.H. Giovanola
- J.J. Lewandowski
- J.L. Derep
- J.L. Derep
- J.R. Johnson
- J.V. Craig
- Jinghua Zhang
- K. Cho
- K. Cho
- K. Cho
- K. Nakajima
- K.A. Hartley
- K.A. Hartley
- K.A. Hartley
- L. Magness
- L. Schultz
- L.E. Murr
- L.E. Murr
- L.E. Murr
- L.E. Murr
- L.E. Murr
- L.E. Murr
- L.F. Liu
- L.H. Dai
- L.W. Meyer
- M Stelly
- M. Stelly
- M. Stelly
- M. Zhou
- M. Zhou
- M. Zhou
- M. Zhou
- M.A. Meyers
- M.A. Meyers
- M.A. Meyers
- M.A. Meyers
- M.A. Meyers
- M.A. Meyers
- M.A. Meyers
- M.A. Meyers
- M.A. Meyers
- M.A. Meyers
- M.E. Backman
- M.E. Backman
- M.E. Kassner
- M.F. Ashby
- M.G. da Silva
- M.G. Mendiratta
- M.R. Staker
- Marc André Meyers
- N.C. Welsh
- P.A. Thornton
- P.G. Shewmon
- P.M. Anderson
- P.R. Guduru
- Q. Li
- Q. Li
- Q. Li
- Q. Wei
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- R. Dormeval
- R.B. Schultz
- R.C. Batra
- R.C. Glenn
- R.D. Conner
- R.E. Winter
- R.F. Recht
- R.J. Clifton
- R.L. Woodward
- R.S. Culver
- R.W. Chen
- S. Kuriyama
- S. Lee
- S. Lee
- S. Mercier
- S. Nemat-Nasser
- S. Walley
- S.A. Manion
- S.A. Manion
- S.C. Liao
- S.C. Liao
- S.J. Manganello
- S.L. Semiatin
- S.L. Semiatin
- S.P. Timothy
- S.P. Timothy
- S.P. Timothy
- S.P. Timothy
- T.A.C. Stock
- T.G. Shawki
- T.J. Burns
- T.S. Eyre
- T.W. Wright
- U. Andrade
- U.F. Kocks
- V. Tvergaard
- V.F. Nesterenko
- V.F. Nesterenko
- V.F. Nesterenko
- Y. Me-Bar
- Y.B. Xu
- Y.B. Xu
- Y.B. Xu
- Y.B. Xu
- Y.B. Xu
- Y.B. Xu
- Y.B. Xu
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- Y.J. Chen
- Y.L. Bai
- Y.L. Bai
- Y.L. Bai
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- Yilong Bai
- Yongbo Xu
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Full text linkObserver-based real-time control for the poloidal beta of the plasma using diamagnetic measurements in tokamak fusion reactors
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- 01/01/2011
- Field of study
No full textThe constant technological advances and progresses in tokamak research constantly show up new control challenges. In this context, the control of the poloidal beta has arisen as a relevant issue. In this paper a real-time observer based on the real-time analysis of diamagnetic measurements that has been developed for the Tokamak à Configuration Variable (TCV) is presented. The algorithm proposed combine measurements of the diamagnetic loops, flux loops and magnetic probes. Afterwards, some simulations are carried out with the purpose of testing the observer. Finally, once the observer has been developed and validated through simulations, it is implemented on the TCV reactor and applied to the real-time control of poloidal beta of the plasma. The results of the experiments show the feasibility of the observer for real-time tokamak plasma control purposes. © 2011 IEEE
The deformation of particle-containing aluminium single crystals
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textOn the origin of shear bands in textured polycrystals
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textOverview of recent and current research on the TCV tokamak
- Author
- Bortolon A.
- Camenen Y.
- Canal G.P.
- Chapman I.T.
- Coda S.
- Duval B.P.
- Felici F.
- Felici F.
- Felici F.
- Felici F.
- Gnesin S.
- Goodman T.P.
- Hofmann F.
- Hofmann F.
- ITER Technical Basis
- Kamleitner J.
- Kirneva N.A.
- Kirneva N.A.
- Labit B.
- Labit B.
- Lauret M.
- Lazzaro E.
- Liang Y.
- Piras F.
- Pochelon A.
- Porte L.
- Rebut P.H.
- Romero J.A.
- Romero J.A.
- Rossel J.X.
- Rossel J.X.
- S. Coda for the TCV Team
- Scaggion A.
- Sevillano M.G.
- Vijvers W.A.J.
- Vijvers W.A.J.
- Witvoet G.
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
No full textThe STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy
- Author
- Agraz Pamplona Irene
- Alcázar R.
- Avila A.
- Avila A.
- Barrio V.
- Blasco M.
- Bonet J.
- Bonet J.
- Cabello V.
- Cao M.
- Caravaca-Fontan F.
- Caravaca-Fontan F.
- DaSilva Santos Iara
- Diaz M.
- Diezhandino M.G.
- Díaz Encarnación Montserrat Mercedes
- Egido J.
- Espinosa M.
- Fernández-Juárez G.
- Galeano C.
- Goicoechea M.
- Gutiérrez E.
- Gómez-Martino J.R.
- Hofstra Julia
- Huerta A.
- Justino J.
- Lambeau G.
- Logt A.E.v.d.
- Malek T.
- Martín M.
- Martín-Reyes G.
- Muñiz A.L.
- Navarro M.
- Ortiz A.
- Paraíso V.
- Perea L.
- Plaisier E.
- Praga M.
- Pérez Valdivia M.A.
- Quintana L.F.
- Rabasco C.
- Rivas B.
- Rodríguez-Moreno A.
- Rodríguez-Paternina E.
- Rojas-Rivera J.
- Romera A.
- Ronco P.
- Segarra A.
- Segarra A.
- Sevillano A.
- Shabaka A.
- Trujillo H.
- Universitat Autònoma de Barcelona
- Valera I.
- Varela A.
- Verdalles Ú.
- Vigil A.
- Wetzels J.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
No full textInternational audienc
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
No full textCharacterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)
