Optional games on cycles and complete graphs

We study stochastic evolution of optional games on simple graphs. There are two strategies, A and B, whose interaction is described by a general payoff matrix. In addition there are one or several possibilities to opt out from the game by adopting loner strategies. Optional games lead to relaxed social dilemmas. Here we explore the interaction between spatial structure and optional games. We find that increasing the number of loner strategies (or equivalently increasing mutational bias toward loner strategies) facilitates evolution of cooperation both in well-mixed and in structured populations. We derive various limits for weak selection and large population size. For some cases we derive analytic results for strong selection. We also analyze strategy selection numerically for finite selection intensity and discuss combined effects of optionality and spatial structure

Estimates of Discharge Coefficient in Levee Breach Under Two Different Approach Flow Types

The amount of released water (discharge) in a levee breach is a primary input variable to establish an emergency action plan for the area next to the levee. However, although several studies have been conducted, there is still no widely applicable discharge coefficient formula; this needs to be known to estimate discharge amount through an opening caused by a levee breach. Sometimes, the discharge coefficient developed for a sharp crested side weir is used to rate the discharge, but, in case of a levee breach, the resulting geometry and flow types are similar to that over a broad crested weir. Thus, in this study, two different openings—rectangular and trapezoidal shape—are constructed in the center of a levee at a height of 0.6m to replicate levee breach scenarios, and the effect of two different approach flow types—the river type approach and reservoir type approach—are explored to suggest a discharge coefficient formula applicable for discharge rating for a levee breach. The results show that the ratio of head above the bottom of an opening and the opening width is a key variable for calculating the discharge coefficient of a reservoir type, but the approach Froude number should also be considered for a river type approach. The measured data are used to improve rating equations and will be useful in the future to validate computational fluid dynamics simulations of wave propagation during levee failure into the inundation area

miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenol

Background: It is known that some environmental chemicals affect the human endocrine system. The harmful effects of endocrine disrupting chemical (EDC) nonylphenol (NP) have been studied since the 1980s. It is known that NP adversely affects physiological functions by mimicking the natural hormone 17 beta-estradiol. In the present study, we analyzed the expression of miRNAs and their target genes in mouse Sertoli TM4 cells to better understand the regulatory roles of miRNAs on Sertoli cells after NP exposure. Methods: Mouse TM4 Sertoli cells were treated with NP for 3 or 24 h, and global gene and miRNA expression were analyzed using Agilent mouse whole genome and mouse miRNA v13 arrays. Results: We identified genes that were > 2-fold differentially expressed in NP-treated cells and control cells (P < 0.05) and analyzed their functions through Gene Ontology analysis. We also identified miRNAs that were differentially expressed in NP-treated and control cells. Of the 186 miRNAs the expression of which differed between NP-treated and control cells, 59 and 147 miRNAs exhibited 1.3-fold increased or decreased expression at 3 and 24 h, respectively. Network analysis of deregulated miRNAs suggested that Ppara may regulate the expression of certain miRNAs, including miR-378, miR-125a-3p miR-20a, miR-203, and miR-101a, after exposure to NP. Additionally, comprehensive analysis of predicted target genes for miRNAs showed that the expression of genes with roles in cell proliferation, the cell cycle, and cell death were regulated by miRNA in NP-treated TM4 cells. Levels of expression of the miRNAs miR-135a* and miR-199a-5p were validated by qRT-PCR. Finally, miR-135a* target gene analysis suggests that the generation of reactive oxygen species (ROS) following exposure to NP exposure may be mediated by miR-135a* through regulation of the Wnt/beta-catenin signaling pathway. Conclusions: Collectively, these data help to determine NP's actions on mouse TM4 Sertoli cells and increase our understanding of the molecular mechanisms underlying the adverse effects of xenoestrogens on the reproductive system.This work was supported an Eco-Technopia 21 project grant from the Ministry of Environment (Development of Decision Method of Chromosomal Abnormality in Reproductive System by Toxic Substances at the Korea Institute of Toxicology)

Electric double-layer capacitor performance of a new mesoporous carbon

A new mesoporous carbon (NMC) was prepared, and its performance in an electric double-layer capacitor (EDLC) was compared to that of a conventional carbon (a molecular-sieving carbon, MSC25). The effect of pore size and pore connection pattern on EDLC performance was demonstrated. To prepare NMC, phenol resin was synthesized inside the pores of an inorganic template, Mobile Composite Material 48 (MCM48), and the resulting resin-template composite was carbonized at 700 degrees C under Ar atmosphere. A coke-like carbonaceous material was obtained after removing the inorganic template by HF treatment. The surface area of NMC was 1257 m(2) g(-1) which is smaller than that of MSC25 (1970 m(2) g(-1)). NMC had three-dimensionally interconnected mesopores (2.3 nm average diam), but randomly connected cage-like micropores (<2.0 nm) were dominant in MSC25. The difference in the pore size and pore connection pattern between the two carbons gave rise to a remarkable difference in their EDLC performances. NMC exhibited a smaller specific capacitance (about 120 F g(-1)) than MSC25 as a result of its smaller surface area, but it showed a higher critical scan rate than the MSC25 electrode due to a smaller resistance-capacitance (RC) time constant. The specific charging capacity of the NMC electrode was about 20 mAh g(-1) and was largely invariant vs. the charge-discharge rate. This was contrasted by MSC25 which showed a steadily decreasing capacity with an increase in rate. As a result, the NMC electrode outperformed the MSC25 based on rate capability. The smaller RC time constant and better rate capability of the NMC electrode apparently arises from the lower electrolyte resistance in pores, which in turn stems from the faster ionic motion in larger pores. (C) 2000 The Electrochemical Society. S0013-4651(00)01-080-6. All rights reserved.This work was supported by the Brain Korea 21 Project.

The Impact of Overactive Bladder on Health-Related Quality of Life, Sexual Life and Psychological Health in Korea

Purpose We aimed to estimate the prevalence of overactive bladder (OAB) in Korea, to assess the variation in prevalence by sex and age, and to measure the impact of OAB on quality of life. Methods A population-based, cross-sectional telephone survey was conducted between April and June 2010 with a questionnaire regarding the prevalence of OAB, demographics, and the impact of OAB on quality of life. A geographically stratified random sample of men and women aged ≥30 years was selected. Results The overall prevalence of OAB was 22.9% (male, 19%; female, 26.8%). Of a total of 458 participants with OAB, 37.6% and 19.9% reported moderate or severe impact on their daily life and sexual life (5.6% and 3.5%, respectively, in participants without OAB). Anxiety and depression were reported by 22.7% and 39.3% of participants with OAB, respectively (9.7% and 22.8%, respectively, in participants without OAB). Only 19.7% of participants with OAB had consulted a doctor for their voiding symptoms, but 50.7% of respondents with OAB were willing to visit a hospital for the management of their OAB symptoms. Conclusions This study confirmed that OAB symptoms are highly prevalent in Korea, and many sufferers appear to have actively sought medical help. OAB has severe effects on daily and sexual life as well as psychological health