Disc haemorrhage associated with an enlarged peripapillary intrachoroidal cavitation in a non-glaucomatous myopic eye: a case report

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Abstract Background Disc haemorrhage (DH) is considered a characteristic sign of glaucoma, but its causative mechanism remains to be determined. We present a case of DH that occurred in association with an enlarged peripapillary intrachoroidal cavitation in a non-glaucomatous eye. Case presentation A 35-year-old woman was evaluated for a DH that had been detected during a preoperative examination for myopic refractive surgery. Enhanced depth imaging spectral-domain optical coherence tomography imaging of the optic nerve revealed a peripapillary intrachoroidal cavitation adjacent to the DH. The DH was also present at the 1-year follow-up, but had been completely absorbed at the 2-year follow-up, respectively with an enlargement and shrinkage of the intrachoroidal cavitation and prelaminar tissue schisis. Glaucomatous optic nerve change was not observed during the entire follow-up. Conclusion DH can be caused by mechanical damage to capillaries from microscopic changes in peripapillary tissues such as enlargement of the intrachoroidal cavitation, regardless of the presence of glaucoma

Cinnamaldehyde enhances in vitro parameters of immunity and reduces in vivo infection against avian coccidiosis

The effects of cinnamaldehyde (CINN) on in vitro parameters of immunity and in vivo protection against avian coccidiosis were evaluated. In vitro stimulation of chicken spleen lymphocytes with CINN (25-400ng/ml) induced greater cell proliferation compared with the medium control (P<0·001). CINN activated cultured macrophages to produce higher levels of NO at 1·2-5·0μg/ml (P<0·001), inhibited the growth of chicken tumour cells at 0·6-2·5μg/ml (P<0·001) and reduced the viability of Eimeria tenella parasites at 10 and 100μg/ml (P<0·05 and P<0·001, respectively), compared with media controls. In chickens fed a diet supplemented with CINN at 14·4mg/kg, the levels of IL-1β, IL-6, IL-15 and interferon-γ transcripts in intestinal lymphocytes were 2- to 47-fold higher (P<0·001) compared with chickens given a non-supplemented diet. To determine the effect of CINN diets on avian coccidiosis, chickens were fed diets supplemented with CINN at 14·4mg/kg (E. maxima or E. tenella) or 125mg/kg (E. acervulina) from hatch for 24d, and orally infected with 2·0×104 sporulated oocysts at age 14d. CINN-fed chickens showed 16·5 and 41·6% increased body-weight gains between 0-9d post-infection (DPI) with E. acervulina or E. maxima, reduced E. acervulina oocyst shedding between 5-9 DPI and increased E. tenella-stimulated parasite antibody responses at 9 DPI compared with control

Dietary supplementation of young broiler chickens with Capsicum and turmeric oleoresins increases resistance to necrotic enteritis

The Clostridium-related poultry disease, necrotic enteritis (NE), causes substantial economic losses on a global scale. In the present study, a mixture of two plant-derived phytonutrients, Capsicum oleoresin and turmeric oleoresin (XT), was evaluated for its effects on local and systemic immune responses using a co-infection model of experimental NE in commercial broilers. Chickens were fed from hatch with a diet supplemented with XT, or with a non-supplemented control diet, and either uninfected or orally challenged with virulent Eimeria maxima oocysts at 14d and Clostridium perfringens at 18d of age. Parameters of protective immunity were as follows: (1) body weight; (2) gut lesions; (3) serum levels of C. perfringens α-toxin and NE B-like (NetB) toxin; (4) serum levels of antibodies to α-toxin and NetB toxin; (5) levels of gene transcripts encoding pro-inflammatory cytokines and chemokines in the intestine and spleen. Infected chickens fed the XT-supplemented diet had increased body weight and reduced gut lesion scores compared with infected birds given the non-supplemented diet. The XT-fed group also displayed decreased serum α-toxin levels and reduced intestinal IL-8, lipopolysaccharide-induced TNF-α factor (LITAF), IL-17A and IL-17F mRNA levels, while cytokine/chemokine levels in splenocytes increased in the XT-fed group, compared with the animals fed the control diet. In conclusion, the present study documents the molecular and cellular immune changes following dietary supplementation with extracts of Capsicum and turmeric that may be relevant to protective immunity against avian N

Reduction of the Lamina Cribrosa Curvature After Trabeculectomy in Glaucoma

PURPOSE. To investigate whether the lamina cribrosa (LC) curvature is decreased after trabeculectomy. METHODS. Thirty-nine eyes of 39 patients with primary open-angle glaucoma who underwent trabeculectomy were included. Optic nerves were scanned by using enhanced-depth-imaging spectral-domain optical coherence tomography before and after trabeculectomy. The LC curvature was assessed by measuring the LC curvature index (LCCI) in seven horizontal Bscan images in each eye. RESULTS. The LCCI was significantly smaller at postoperative 6 months than at the preoperative level in all seven planes (all P &lt; 0.001). Preoperative LCCI was associated with younger age at superior midperiphery, midhorizontal plane, inferior midperiphery (all P 0.005) and higher preoperative intraocular pressure (IOP) at superior and inferior midperiphery (both P ¼ 0.039). Younger age and larger preoperative LCCI were associated with a larger reduction of the LCCI at all three locations (P ¼ 0.003 and 0.031 at superior midperiphery, P ¼ 0.011 and 0.001 at midhorizontal plane, and P ¼ 0.014 and 0.005 at inferior midperiphery, respectively), whereas the percentage IOP lowering was associated at superior and inferior midperiphery (P ¼ 0.017 and 0.047, respectively). CONCLUSIONS. Lamina cribrosa curvature was reduced after trabeculectomy. This finding suggests that LC curvature may have value as a parameter relevant to optic nerve head biomechanics

Association between Optic Nerve Sheath Diameter and Lamina Cribrosa Morphology in Normal-Tension Glaucoma

(1) Background: To compare optic nerve sheath diameter (ONSD) in normal-tension glaucoma (NTG) and healthy eyes and to investigate the association between ONSD and lamina cribrosa (LC) morphology. (2) Methods: This cross-sectional study included 69 NTG eyes and 69 healthy eyes matched for age, axial length, and intraocular pressure. The LC curvature index (LCCI) was measured from horizontal Cirrus HD-OCT B-scan images from five uniformly divided positions vertically of the optic nerve. The average LCCI was defined as the mean of the measurements at these five locations. ONSD was measured as the width of the optic nerve sheath at the site perpendicular 3 mm behind the posterior globe. LCCI and ONSD were compared in eyes with NTG and healthy eyes. The clinical factors that could affect LCCI were analyzed. (3) Results: NTG eyes had significantly smaller mean ONSD (4.55 ± 0.69 mm vs. 4.97 ± 0.58 mm, p p < 0.001) than matched healthy control eyes. LCCI was significantly correlated with smaller ONSD, higher intraocular pressure, thinner global retinal nerve fiber thickness, and worse visual field loss in all subjects (all Ps ≤ 0.022). (4) Conclusions: NTG eyes had smaller ONSD and greater LCCI than healthy control eyes. In addition, a negative correlation was observed between ONSD and LCCI. These findings suggest that cerebrospinal fluid pressure, which ONSD indirectly predicts, may affect LC configuration. Changes in the retrolaminar compartment may play a role in glaucoma pathogenesis

Actual anterior–posterior corneal radius ratio in eyes with prior myopic laser vision correction according to axial length

Abstract We retrospectively evaluate the actual anterior–posterior (AP) corneal radius ratio in eyes with previous laser correction for myopia (M-LVC) according to axial length (AL) using biometry data exported from swept-source optical coherence tomography between January 2018 and October 2021 in a tertiary hospital (1018 eyes with a history of M-LVC and 19,841 control eyes). The AP ratio was significantly higher in the LVC group than in the control group. Further, it was significantly positively correlated with AL in the LVC group. We also investigated the impact of the AP ratio, AL and keratometry (K) on the absolute prediction error (APE) in 39 eyes that underwent cataract surgery after M-LVC. In linear regression analyses, there were significant correlations between APE and AL/TK, while APE and AP ratio had no correlation. The APE was significantly lower in the Barrett True-K with total keratometry (Barrett True-TK) than in the Haigis-L formula on eyes with AL above 26 mm and K between 38 and 40 D. In conclusion, in eyes with previous M-LVC, AP ratio increases with AL. The Barrett True-K or Barrett True-TK formulas are recommended rather than Haigis-L formula in M-LVC eyes with AL above 26 mm and K between 38 and 40D

Lamina Cribrosa Curvature in Healthy Korean Eyes

Abstract Given that posterior bowing of the lamina cribrosa (LC) is a principle event in the development of glaucomatous damage, assessment of the LC morphology may have clinical utility in diagnosing and managing glaucoma patients. LC curvature has been suggested as an index to evaluate the LC morphology. To apply LC morphology in clinical practice, it is necessary to know normal profiles of LC curvature in healthy population. This study was performed to investigate the characteristics of LC curvature in healthy eyes using enhanced depth imaging spectral-domain optical coherence tomography in a total of 250 eyes of 125 healthy Korean subjects. The lamina cribrosa curvature index (LCCI) values at seven locations spaced equidistantly across the vertical optic disc diameter were measured on serial horizontal B-scan images. The mean value of the seven measurements was defined as the average LCCI. The average LCCI was 7.46 ± 1.22 (range, 4.29–10.48) and did not differ significantly between the right and left eyes. There was a strong inter-eye correlation within subjects. LCCI was significantly larger in eyes with shorter axial length (P < 0.001). The observed range of LCCI in healthy subjects may be used as a reference for evaluating LC curvature in glaucomatous eyes

Comparison between Lamina Cribrosa Depth and Curvature as a Predictor of Progressive Retinal Nerve Fiber Layer Thinning in Primary Open-Angle Glaucoma

International audiencePurposeTo compare the ability of lamina cribrosa (LC) depth (LCD) and LC curvature to predict the rate of progressive retinal nerve fiber layer (RNFL) thinning in patients with primary open-angle glaucoma (POAG).DesignObservational case series.ParticipantsA total of 114 eyes of 114 patients diagnosed with POAG, in which RNFL thickness had been measured by serial spectral-domain (SD) OCT for at least 2.5 years.MethodsThe optic nerves of all participants underwent enhanced depth imaging volume scanning, and their circumpapillary RNFL thickness was measured using SD OCT, followed by regular serial measurements of RNFL thickness at intervals of ≥6 months. The LCD from the levels of Bruch’s membrane (BM, LCD-BM) and the anterior sclera (AS, LCD-AS), and LC curvature index (LCCI) were measured by SD OCT at 3 locations: superior midperipheral, midhorizontal, and inferior midperipheral. The rate of RNFL thinning over time was determined by linear regression of serial OCT measurements of RNFL thickness.Main Outcome MeasuresFactors associated with the rate of OCT RNFL thinning.ResultsUnivariate analysis showed that larger LCD-BM (P = 0.001), LCD-AS (P < 0.001), and LCCI (P < 0.001) were all significantly associated with a faster rate of global RNFL thinning. The LCCI showed a stronger correlation with the rate of global RNFL thinning than LCD-BM (P < 0.001) or LCD-AS (P < 0.001). Of the 3 variables, only LCCI remained significant on multivariate analysis (P < 0.001). Disc hemorrhage during follow-up (P = 0.003), wider parapapillary atrophy β-zone (P = 0.017), and greater global RNFL thickness (P = 0.040) were also significantly associated with a faster rate of global RNFL thinning.ConclusionsMorphology of LC was significantly associated with the rate of progressive RNFL thinning. Curvature of LC better predicted progressive RNFL thinning than did LCD measured from the BM or AS

Factors Associated with the Retinal Nerve Fiber Layer Loss after Acute Primary Angle Closure: A Prospective EDI-OCT Study

<div><p>Purpose</p><p>To determine the factors associated with retinal nerve fiber layer (RNFL) loss in eyes with acute primary angle-closure (APAC), particularly focusing on the influence of the change in the anterior lamina cribrosa surface depth (LCD).</p><p>Methods</p><p>After the initial presentation, 30 eyes with unilateral APAC were followed up at the following specific time points over a 12-month period: 1 week, 1~2 months, 2~3 months, 5~6 months, and 11~12 months. These follow-ups involved intraocular pressure measurements, enhanced depth-imaging spectral-domain optical coherence tomography (SD-OCT) scanning of the optic disc, and measurements of the circumpapillary RNFL thickness. The prelaminar tissue thickness (PLT) and LCD were determined in the SD-OCT images obtained at each follow-up visit.</p><p>Results</p><p>Repeated measures analysis of variance revealed a significant pattern of decrease in the global RNFL thickness, PLT, and LCD (all <i>p</i><0.001). The global RNFL thickness decreased continuously throughout the follow-up period, while the PLT decreased until 5~6 months and did not change thereafter. The LCD reduced until 2~3 months and then also remained steady. Multivariable regression analysis revealed that symptoms with a longer duration before receiving laser peripheral iridotomy (LI) (<i>p</i> = 0.049) and a larger LCD reduction (<i>p</i> = 0.034) were significant factors associated with the conversion to an abnormal RNFL thickness defined using OCT normative data.</p><p>Conclusion</p><p>Early short-term decreases in the PLT and LCD and overall long-term decrease in the peripapillary RNFL were observed during a 12-month follow-up after an APAC episode. A longer duration of symptoms before receiving LI treatment and larger LCD reduction during follow-up were associated with the progressive RNFL loss. The LCD reduction may indicate a prior presence of significant pressure-induced stress that had been imposed on the optic nerve head at the time of APAC episode. Glaucomatous progression should be suspected in eyes showing LCD reduction after the APAC remission.</p></div

Reduction of the Lamina Cribrosa Curvature After Trabeculectomy in Glaucoma

International audiencePURPOSE. To investigate whether the lamina cribrosa (LC) curvature is decreased after trabeculectomy.METHODS. Thirty-nine eyes of 39 patients with primary open-angle glaucoma who underwent trabeculectomy were included. Optic nerves were scanned by using enhanced-depth-imaging spectral-domain optical coherence tomography before and after trabeculectomy. The LC curvature was assessed by measuring the LC curvature index (LCCI) in seven horizontal B-scan images in each eye.RESULTS. The LCCI was significantly smaller at postoperative 6 months than at the preoperative level in all seven planes (all P < 0.001). Preoperative LCCI was associated with younger age at superior midperiphery, midhorizontal plane, inferior midperiphery (all P < 0.005) and higher preoperative intraocular pressure (IOP) at superior and inferior midperiphery (both P = 0.039). Younger age and larger preoperative LCCI were associated with a larger reduction of the LCCI at all three locations (P = 0.003 and 0.031 at superior midperiphery, P = 0.011 and 0.001 at midhorizontal plane, and P = 0.014 and 0.005 at inferior midperiphery, respectively), whereas the percentage lOP lowering was associated at superior and inferior midperiphery (P = 0.017 and 0.047, respectively).CONCLUSIONS. Lamina cribrosa curvature was reduced after trabeculectomy. This finding suggests that LC curvature may have value as a parameter relevant to optic nerve head biomechanics