8 research outputs found

    Prior dengue virus exposure shapes T Cell immunity to Zika Virus in humans

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    While progress has been made in characterizing humoral immunity to Zika virus (ZIKV) in humans, little is known regarding the corresponding T cell responses to ZIKV. Here we investigate the kinetics and viral epitopes targeted by T cells responding to ZIKV and address the critical question of whether pre-existing dengue virus (DENV) T cell immunity modulates these responses. We find that memory T cell responses elicited by prior infection with DENV or vaccination with Tetravalent Dengue Attenuated Vaccines (TDLAV) recognize ZIKV-derived peptides. This cross-reactivity is explained by the sequence similarity of the two viruses, as the ZIKV peptides recognized by DENV-elicited memory T cells are identical or highly conserved in DENV and ZIKV. DENV exposure prior to ZIKV infection also influences the timing and magnitude of the T cell response. ZIKV-reactive T cells in the acute phase of infection are detected earlier and in greater magnitude in DENV-immune patients. Conversely, the frequency of ZIKV-reactive T cells continues to rise in the convalescent phase in DENV-naive donors, but declines in DENV pre-exposed donors, compatible with more efficient control of ZIKV replication and/or clearance of ZIKV antigen. The quality of responses is also influenced by previous DENV exposure, and ZIKV-specific CD8 T cells form DENV pre-exposed donors selectively up-regulated granzyme B and PD1, as compared to DENV-naïve donors. Finally, we discovered that ZIKV structural proteins (E, prM and C) are major targets of both the CD4 and CD8 T cell responses, whereas DENV T cell epitopes are found primarily in nonstructural proteins

    ATLAS detector and physics performance: Technical Design Report, 1

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    Novas ocorrências de Rapateaceae para o Brasil New records of Rapateaceae from Brazil

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    Este trabalho apresenta cinco novas ocorrências de Rapateaceae para a flora brasileira, provenientes do Monte Caburaí, Roraima, um tepui de baixa altitude no extremo norte do Brasil. Foram registrados uma espécie de Rapatea Aubl., três de Stegolepis Klotzsch ex Körn, além de uma espécie de Epidryos Maguire, sendo este o primeiro registro do gênero para a flora brasileira. São apresentadas breves descrições, ilustrações, informações sobre a distribuição geográfica e habitat das espécies, bem como comentários sobre suas afinidades taxonômicas.<br>This paper presents five new additions of Rapateaceae to the Brazilian flora from Monte Caburaí, a low-altitude tepui in Roraima state. One species of Epidryos Maguire, another of Rapatea Aubl., and three species of Stegolepis Klotzsch ex Körn were recorded. Epidryos is cited for the first time for the Brazilian flora. Brief descriptions, illustrations, geographic distribution and habitat data as well as comments on taxonomic affinities of the species are presented

    ATLAS calorimeter performance

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    ATLAS computing technical proposal

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    ATLAS computing technical proposal

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    ATLAS detector and physics performance: Technical Design Report, 2

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