Status of Bioprospecting of Marine Molluscs in India

Continuous pressure on the environment arising inevitably or otherwise out of technological progress and human population growth has made it necessary to place a commodity value on biodiversity (Randall, 1991)

Pharmacological utilization of bergamottin, derived from grapefruits, in cancer prevention and therapy

In spite of significant advances in treatment options and the advent of novel targeted therapies, there still remains an unmet need for the identification of novel pharmacological agents for cancer therapy. This has led to several studies evaluating the possible application of natural agents found in vegetables, fruits, or plant-derived products that may be useful for cancer treatment. Bergamottin is a furanocoumarin derived from grapefruits and is also a well-known cytochrome P450 inhibitor. Recent studies have demonstrated potent anti-oxidative, anti-inflammatory, and anti-cancer properties of grapefruit furanocoumarin both in vitro and in vivo. The present review focuses on the potential anti-neoplastic effects of bergamottin in different tumor models and briefly describes the molecular targets affected by this agent

Molecular Imaging of Petroleum Asphaltenes by Scanning Tunneling Microscopy: Verification of Structure from 13C and Proton Nuclear Magnetic Resonance Data

Scanning tunneling microscopy (STM) was used to verify the molecular structure of Maya asphaltene which had been derived from combined 13C and proton nuclear magnetic resonance (NMR) experiments. Petroleum asphaltenes are known to contain large polynuclear aromatic centers with aliphatic sidechains. Average molecular models of Maya asphaltenes were derived using studies which included combined proton and 13C NMR data to determine total aromatic carbon content and the ratio of peripheral to internal aromatic ring carbons. These parameters permitted estimating the average number of aromatic rings per condensed cluster. These Maya asphaltenes were imaged by scanning tunneling microscopy (STM) in a dilute solution of tetrahydrofuran on highly oriented pyrolytic graphite. The sizes and structures of the asphaltenes as observed by STM are in reasonable agreement with these average molecular models. We observed asymmetric structures whose largest dimension averaged 10.4 Å ± 1.9 Å from 24 separate images. The condensed ring portions of three representative NMR derived molecular models yielded an average dimension of 11.1 Å ± 1.4 Å

Prediction and management of natural disasters through indigenous Technical Knowledge, with special reference to fisheries

Traditional Indigenous knowledge has over the years played a significant role in solving several major social-ecological problems including those related to climate change and variability. People living close to nature often observe the circumstances around them and are the often the first to identify and adapt to any changes. The appearance of certain birds, mating of certain animals and flowering of certain plants are all seen as important signals of change with respect to timing and seasonality of natural phenomena that are well understood in traditional knowledge systems. Indigenous and local peoples have relied on biodiversity as a buffer against environmental variation, change and catastrophe

Linear Sigma Models with Torsion

Gauged linear sigma models with (0,2) supersymmetry allow a larger choice of couplings than models with (2,2) supersymmetry. We use this freedom to find a fully linear construction of torsional heterotic compactifications, including models with branes. As a non-compact example, we describe a family of metrics which correspond to deformations of the heterotic conifold by turning on H-flux. We then describe compact models which are gauge-invariant only at the quantum level. Our construction gives a generalization of symplectic reduction. The resulting spaces are non-Kahler analogues of familiar toric spaces like complex projective space. Perturbatively conformal models can be constructed by considering intersections.Comment: 40 pages, LaTeX, 1 figure; references added; a new section on supersymmetry added; quantization condition revisite